POLE2 and PYGL

		POLE2	PYGL
Description		DNA polymerase epsilon 2, accessory subunit	glycogen phosphorylase L
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Epsilon DNA Polymerase Complex Nuclear Body Nuclear Lumen	Extracellular Region Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	Nucleotide Binding Purine Nucleobase Binding Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding ATP Binding D-glucose Binding Glycogen Phosphorylase Activity AMP Binding Transferase Activity Glycosyltransferase Activity Vitamin Binding Pyridoxal Phosphate Binding Bile Acid Binding Identical Protein Binding
	Biological Process	DNA Metabolic Process DNA Replication DNA-templated DNA Replication DNA Repair Error-prone Translesion Synthesis	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process Response To Bacterium Glucose Homeostasis Necroptotic Process
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs		Cladribine
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Trigger finger ( 32740585)	Acute lymphoblastic leukemia (childhood) ( 23007406) Blood protein levels ( 30072576) Psychosis (atypical) ( 24132900) Rectal cancer ( 33632709)
Interacting Genes		19 interacting genes: AGFG1 BAIAP2L2 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 PKM POLE4 REL SAP18 SORBS3 TBX15 TLE1 TRIM27 UBC UBQLN2 ZBED1 ZNF620	7 interacting genes: BAG1 CEBPA HSD17B10 HSD3B7 IDH2 PYGB PYGM
Entrez ID		5427	5836
HPRD ID		16007	01987
Ensembl ID		ENSG00000100479	ENSG00000100504
Uniprot IDs		P56282	P06737
PDB IDs		2V6Z 5VBN 7PFO 7PLO	1EM6 1EXV 1FA9 1FC0 1L5Q 1L5R 1L5S 1L7X 1XOI 2ATI 2QLL 2ZB2 3CEH 3CEJ 3CEM 3DD1 3DDS 3DDW 8EMS
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Macromolecule Metabolic Process Synaptic Transmission, Dopaminergic Positive Regulation Of Organelle Organization Regulation Of Autophagy Cytosol Transcription Coactivator Activity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of DNA-templated Transcription Auditory Receptor Cell Fate Determination Regulation Of Macromolecule Biosynthetic Process Auditory Receptor Cell Fate Specification Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization RNA Binding Ficolin-1-rich Granule Lumen Secretory Granule Lumen Identical Protein Binding SUMO Transferase Activity PML Body Protein Autosumoylation Histone H2AK5 Acetyltransferase Activity Mitotic Spindle Pole Establishment Of Mitotic Spindle Orientation Attachment Of Mitotic Spindle Microtubules To Kinetochore Attachment Of Spindle Microtubules To Kinetochore Glyoxal Catabolic Process L-dopa Decarboxylase Activator Activity Guanine Deglycation Protein Deglycase Activity Glyoxalase (glycolic Acid-forming) Activity Glycolate Biosynthetic Process Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Detoxification Of Mercury Ion Negative Regulation Of Death-inducing Signaling Complex Assembly Cellular Response To Glyoxal Glyoxal Metabolic Process Positive Regulation Of L-dopa Biosynthetic Process Tyrosine 3-monooxygenase Activator Activity Protein Localization To Astral Microtubule Keratinocyte Apoptotic Process Regulation Of RNA Metabolic Process Establishment Of Mitotic Spindle Localization	Glycogen Phosphorylase Activity 1,4-alpha-oligoglucan Phosphorylase Activity Bile Acid Biosynthetic Process Polysaccharide Catabolic Process Glycogen Catabolic Process Bile Acid Metabolic Process Steroid Metabolic Process Generation Of Precursor Metabolites And Energy RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Pyridoxal Phosphate Binding Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity Carbohydrate Metabolic Process Response To Vitamin B2 C/EBP Complex 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Glyoxylate Cycle Isocitrate Dehydrogenase (NADP+) Activity Monocarboxylic Acid Metabolic Process CHOP-C/EBP Complex Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Carbohydrate Catabolic Process 3-beta-hydroxy-Delta5-steroid Dehydrogenase (NAD+) Activity Oxidoreductase Activity White Fat Cell Proliferation Mitochondrial RNA 5'-end Processing Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Isoleucine Metabolic Process L-isoleucine Catabolic Process Isocitrate Metabolic Process Epsilon DNA Polymerase Complex B Cell Chemotaxis Small Molecule Metabolic Process TRNA Methyltransferase Complex Mitochondrial RNA 3'-end Processing Testosterone Dehydrogenase (NAD+) Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
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