POLE2 and ATOH1

		POLE2	ATOH1
Description		DNA polymerase epsilon 2, accessory subunit	atonal bHLH transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Epsilon DNA Polymerase Complex Nuclear Body Nuclear Lumen	Chromatin Nucleus
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Metabolic Process DNA Replication DNA-templated DNA Replication DNA Repair Error-prone Translesion Synthesis	Neuron Migration Transcription By RNA Polymerase II Notch Signaling Pathway Nervous System Development Axon Guidance Central Nervous System Development Brain Development Sensory Organ Development Negative Regulation Of Gliogenesis Central Nervous System Neuron Differentiation Cerebral Cortex Development Cell Differentiation Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Auditory Receptor Cell Fate Specification Auditory Receptor Cell Fate Determination Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment System Development Inner Ear Development Axon Development Neuroblast Migration Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Inner Ear Receptor Cell Differentiation
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Cladribine
Diseases
GWAS		Trigger finger ( 32740585)	Colorectal cancer or advanced adenoma ( 30510241) Metabolite levels ( 23823483)
Interacting Genes		19 interacting genes: AGFG1 BAIAP2L2 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 PKM POLE4 REL SAP18 SORBS3 TBX15 TLE1 TRIM27 UBC UBQLN2 ZBED1 ZNF620	2 interacting genes: HMGB1 HUWE1
Entrez ID		5427	474
HPRD ID		16007	03270
Ensembl ID		ENSG00000100479	ENSG00000172238
Uniprot IDs		P56282	Q92858
PDB IDs		2V6Z 5VBN 7PFO 7PLO
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Macromolecule Metabolic Process Synaptic Transmission, Dopaminergic Positive Regulation Of Organelle Organization Regulation Of Autophagy Cytosol Transcription Coactivator Activity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of DNA-templated Transcription Auditory Receptor Cell Fate Determination Regulation Of Macromolecule Biosynthetic Process Auditory Receptor Cell Fate Specification Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization RNA Binding Ficolin-1-rich Granule Lumen Secretory Granule Lumen Identical Protein Binding SUMO Transferase Activity PML Body Protein Autosumoylation Histone H2AK5 Acetyltransferase Activity Mitotic Spindle Pole Establishment Of Mitotic Spindle Orientation Attachment Of Mitotic Spindle Microtubules To Kinetochore Attachment Of Spindle Microtubules To Kinetochore Glyoxal Catabolic Process L-dopa Decarboxylase Activator Activity Guanine Deglycation Protein Deglycase Activity Glyoxalase (glycolic Acid-forming) Activity Glycolate Biosynthetic Process Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Detoxification Of Mercury Ion Negative Regulation Of Death-inducing Signaling Complex Assembly Cellular Response To Glyoxal Glyoxal Metabolic Process Positive Regulation Of L-dopa Biosynthetic Process Tyrosine 3-monooxygenase Activator Activity Protein Localization To Astral Microtubule Keratinocyte Apoptotic Process Regulation Of RNA Metabolic Process Establishment Of Mitotic Spindle Localization	Base-excision Repair DNA Repair DNA Metabolic Process Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity DNA Damage Response Ficolin-1-rich Granule Lumen Secretory Granule Lumen Positive Regulation Of Myeloid Progenitor Cell Differentiation Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Autophagy Negative Regulation Of Apoptotic Cell Clearance C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Histone Ubiquitin Ligase Activity Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Negative Regulation Of DNA-templated Transcription Initiation Cellular Response To Stress Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Myeloid Progenitor Cell Differentiation Negative Regulation Of Transcription Initiation By RNA Polymerase II Supercoiled DNA Binding Positive Regulation Of Dendritic Cell Differentiation Regulation Of Endodeoxyribonuclease Activity Neutrophil Clearance Epsilon DNA Polymerase Complex Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway DNA Geometric Change Regulation Of Glycogen Catabolic Process Regulation Of Autophagy Bubble DNA Binding Regulation Of Apoptotic Cell Clearance DNA Binding Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Nucleic Acid Metabolic Process Regulation Of Toll-like Receptor 9 Signaling Pathway DNA Topological Change Endothelial Cell Chemotaxis Error-prone Translesion Synthesis Positive Regulation Of Type 2 Mitophagy RAGE Receptor Binding Regulation Of Mitochondrial Fusion
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