RUVBL1 and KIAA1377

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RUVBL1	KIAA1377
Gene Name		RuvB-like AAA ATPase 1	KIAA1377
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Swr1 Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Microtubule Organizing Center Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome MLL1 Complex	Cytoplasm Centrosome Midbody Ciliary Base
	Molecular Function	DNA Helicase Activity Protein Binding ATP Binding ATPase Activity	Protein Binding
	Biological Process	DNA Repair DNA Recombination Chromatin Organization Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Nuclear Division Spermatogenesis DNA Duplex Unwinding CENP-A Containing Nucleosome Assembly Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Cell Division	Mitotic Spindle Organization Cytoplasmic Microtubule Organization Cilium Assembly
Pathways		Chromosome Maintenance Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex Deposition of new CENPA-containing nucleosomes at the centromere Telomere Extension By Telomerase Extension of Telomeres Signaling by Wnt HATs acetylate histones Chromatin modifying enzymes Telomere Maintenance Nucleosome assembly TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ACTL6A CTNNB1 DKC1 FBL HDAC1 KIAA1377 LZTR1 MRGBP MYC NEDD4 NUFIP1 OFD1 PIH1D1 PLG RUVBL2 STOM TAF9 TBP TERT TK1	86 interactors: AIMP2 AKTIP ARIH2 ATP6V1F ATRX BMI1 BRD1 C11orf58 CDKN2B CRCT1 CSTF2 DGCR6 DISC1 DLEU1 DNM1 DUSP12 DUSP23 EIF2S2 EIF6 EPN1 FAM118B FAM134A FEZ1 FGFR3 FXR1 GEMIN7 GET4 GIT1 GOLGB1 GPRASP2 GSTO1 HMOX2 HTT ING5 KAT5 KAT7 KIF15 KLHL20 LAMTOR5 LPL LRRC1 LUC7L2 MAD2L1BP MAPK9 MRPS6 NAP1L5 NAT9 NPM3 NSF NUDT21 ODF2L OFD1 PBK PDCD5 PFDN1 PIK3R3 PMF1 POLD1 POLR2M PPP1CA PPP1CC PRKRA PTPRS RAB27A RAN RBM23 RGS2 RIF1 ROGDI RPA2 RUVBL1 SAT1 SNRPG SPDL1 STAU2 TFG TNFRSF14 TNFSF11 TOMM20 TTR TXNDC9 VIM YAE1D1 YWHAZ ZBED8 ZNF24
Entrez ID		8607	57562
HPRD ID		09143	17212
Ensembl ID		ENSG00000175792	ENSG00000110318
Uniprot IDs		Q9Y265	Q9P2H0
PDB IDs		2C9O 2XSZ
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromosome Organization Chromatin Organization Organelle Organization RNA Metabolic Process Box C/D SnoRNP Assembly Nucleobase-containing Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Histone Modification Chromatin Remodeling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Cellular Response To UV Cellular Nitrogen Compound Metabolic Process Fungiform Papilla Formation Gene Expression Negative Regulation Of Signaling Telomere Maintenance Via Telomerase DNA-templated Transcription, Initiation Fungiform Papilla Morphogenesis Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Fungiform Papilla Development RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Light Stimulus Developmental Process Nitrogen Compound Metabolic Process Histone H2A Acetylation Hair Follicle Placode Formation Cellular Component Assembly Tongue Morphogenesis DNA Biosynthetic Process Histone Acetylation Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Internal Peptidyl-lysine Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation RNA-dependent DNA Replication Protein Acetylation Response To UV Regulation Of Transcription, DNA-templated	Organelle Organization Cell Cycle Mitotic Cell Cycle Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Metabolic Process Mitotic Cell Cycle Process Cellular Process Response To Light Stimulus Response To Radiation Triglyceride Catabolic Process Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Organelle Localization Acylglycerol Catabolic Process Endomembrane System Organization Establishment Of Organelle Localization Cell Cycle Process Positive Regulation Of Signal Transduction Peptidyl-lysine Modification Endosome Organization Protein Localization To Organelle Positive Regulation Of Metabolic Process Anatomical Structure Development System Development Regulation Of Signal Transduction Termination Of RNA Polymerase II Transcription Cytoplasmic Transport Programmed Cell Death Chromosome Organization Cell Division Ribosomal Subunit Export From Nucleus Cell Death Regulation Of Signaling Cellular Response To Stimulus Death Histone H3 Acetylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Ubiquitination Mitotic Nuclear Division Ribonucleoprotein Complex Biogenesis Response To Abiotic Stimulus Positive Regulation Of Striated Muscle Contraction Cellular Response To Organic Substance RNA Metabolic Process Organ Development Neurotransmitter Uptake
Tagcloud ?		anaemia aplastic assemble atpases conditional confers core crosslinker crosslinks depletion encode fa fanconi haematopoietic hallmark instability interstrand lethal monoubiquitin multisubunit pool profound purify repairs senses stringent surprisingly vertebrate
Tagcloud (Difference) ?		anaemia aplastic assemble atpases conditional confers core crosslinker crosslinks depletion encode fa fanconi haematopoietic hallmark instability interstrand lethal monoubiquitin multisubunit pool profound purify repairs senses stringent surprisingly vertebrate
Tagcloud (Intersection) ?