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GTF2H4 and GTF2F1
Number of citations of the paper that reports this interaction (PubMedID
9159119
)
32
Data Source:
BioGRID
(biochemical, pull down, affinity chromatography technology)
GTF2H4
GTF2F1
Description
general transcription factor IIH subunit 4
general transcription factor IIF subunit 1
Image
GO Annotations
Cellular Component
Core TFIIH Complex Portion Of Holo TFIIH Complex
Transcription Factor TFIIH Core Complex
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIH Holo Complex
Nuclear Speck
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIF Complex
Cell Junction
Protein-containing Complex
Molecular Function
ATPase Activator Activity
Double-stranded DNA Binding
Protein Binding
RNA Polymerase II General Transcription Initiation Factor Activity
RNA Polymerase II General Transcription Initiation Factor Binding
TFIIF-class Transcription Factor Complex Binding
DNA Binding
RNA Binding
Protein Binding
RNA Polymerase II General Transcription Initiation Factor Activity
Phosphatase Activator Activity
Protein Phosphatase Binding
Protein Domain Specific Binding
Promoter-specific Chromatin Binding
Biological Process
DNA Repair
Nucleotide-excision Repair
Transcription By RNA Polymerase II
DNA Damage Response
Transcription By RNA Polymerase II
Transcription Initiation At RNA Polymerase II Promoter
Transcription Elongation By RNA Polymerase II
Response To Virus
Negative Regulation Of Protein Binding
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Drugs
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Conotruncal heart defects (maternal effects) (
28468790
)
Malaria (
31844061
)
Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) (
26651848
)
Schizophrenia (
28991256
)
Ulcerative colitis (
20848476
)
Interacting Genes
13 interacting genes:
EAF1
EIF1AD
ERCC3
ERCC5
GTF2B
GTF2E1
GTF2F1
POLR2A
SREK1IP1
TBP
TP53
UBC
XBP1P1
34 interacting genes:
ABL1
AHR
AR
ARNT
ATF7IP
BCL2L13
CCNT1
CDK9
CEBPA
CFTR
CSNK2A1
CTDP1
CTDSP1
DAPK1
FEZ1
FNDC3B
FOS
GTF2A1
GTF2B
GTF2E1
GTF2E2
GTF2F2
GTF2H4
JUN
MAGEC1
MSX2
MYC
PARP1
PSMC2
PTN
SRF
TAF1
TAF11
TRIM27
Entrez ID
2968
2962
HPRD ID
03456
01803
Ensembl ID
ENSG00000213780
ENSG00000125651
Uniprot IDs
A0A1U9X7S4
Q92759
P35269
PDB IDs
5IVW
5IY6
5IY7
5IY8
5IY9
5OF4
6NMI
6O9L
6O9M
6RO4
7AD8
7EGB
7EGC
7ENA
7ENC
7LBM
7NVR
7NVV
7NVW
7NVX
7NVY
7NVZ
7NW0
8BVW
8BYQ
8EBS
8EBT
8EBU
8EBV
8EBW
8EBX
8EBY
8GXQ
8GXS
8WAK
8WAL
8WAN
8WAO
8WAP
8WAQ
8WAR
8WAS
1F3U
1I27
1J2X
1NHA
1ONV
2K7L
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6O9L
7EDX
7EG7
7EG8
7EG9
7EGA
7EGB
7EGC
7ENA
7ENC
7LBM
7NVR
7NVS
7NVT
7NVU
7NVY
7NVZ
7NW0
7ZWD
7ZX7
7ZX8
8BVW
8BYQ
8BZ1
8GXQ
8GXS
8S51
8S52
8S54
8S55
8S5N
8WAK
8WAL
8WAN
8WAO
8WAP
8WAQ
8WAR
8WAS
8WAT
8WAU
8WAV
8WAW
8WAX
8WAY
8WAZ
8WB0
Enriched GO Terms of Interacting Partners
?
Transcription Factor TFIID Complex
Transcription Initiation At RNA Polymerase II Promoter
Promoter-specific Chromatin Binding
DNA-templated Transcription Initiation
DNA-templated Transcription
RNA Polymerase II General Transcription Initiation Factor Activity
Transcription Elongation By RNA Polymerase II
Transcription By RNA Polymerase II
DNA-templated Transcription Elongation
Nucleobase-containing Compound Biosynthetic Process
Nucleoplasm
RNA Metabolic Process
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
Macromolecule Biosynthetic Process
Nucleotide-excision Repair
RNA Polymerase II General Transcription Initiation Factor Binding
MRNA Transcription
Macromolecule Metabolic Process
Transcription-coupled Nucleotide-excision Repair
Transcription Preinitiation Complex
Response To UV-C
Nucleus
Ubiquitin Protein Ligase Binding
Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Nuclear Body
Response To UV
RNA Polymerase II Complex Binding
14-3-3 Protein Binding
Protein-DNA Complex Assembly
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Molecular Condensate Scaffold Activity
Nucleotide-excision Repair Factor 3 Complex
Transcriptional Start Site Selection At RNA Polymerase II Promoter
RNA Polymerase II Preinitiation Complex Assembly
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Helicase Activity
Negative Regulation Of G1 To G0 Transition
DNA Binding
Transcription Preinitiation Complex Assembly
Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
P53 Binding
Cellular Response To Diamide
Damaged DNA Binding
RNA Polymerase II Core Complex Assembly
Transcription Factor TFIIE Complex
TFIIF-class Transcription Factor Complex Binding
Transcription Factor TFIIF Complex
MRNA Metabolic Process
Transcription By RNA Polymerase II
DNA-templated Transcription
RNA Polymerase II General Transcription Initiation Factor Activity
Transcription Initiation At RNA Polymerase II Promoter
Nucleobase-containing Compound Biosynthetic Process
Transcription Factor TFIID Complex
DNA-templated Transcription Initiation
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Transcription By RNA Polymerase II
RNA Metabolic Process
Nucleus
Positive Regulation Of DNA-templated Transcription Initiation
Nucleoplasm
Host-mediated Activation Of Viral Transcription
Regulation Of DNA-templated Transcription Initiation
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Macromolecule Biosynthetic Process
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Transcription Regulator Complex
Nucleic Acid Metabolic Process
TBP-class Protein Binding
Positive Regulation Of RNA Metabolic Process
DNA Binding
Host-mediated Perturbation Of Viral Transcription
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Host-mediated Activation Of Viral Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription Cis-regulatory Region Binding
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of MiRNA Metabolic Process
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Positive Regulation Of Metabolic Process
RNA Polymerase II General Transcription Initiation Factor Binding
RNA Polymerase II Transcription Regulator Complex
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription Initiation By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of MiRNA Transcription
Host-mediated Perturbation Of Viral Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
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