GTF2H4 and ERCC5

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GTF2H4	ERCC5
Description		general transcription factor IIH subunit 4	ERCC excision repair 5, endonuclease
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GO Annotations	Cellular Component	Core TFIIH Complex Portion Of Holo TFIIH Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Nuclear Speck	Nucleotide-excision Repair Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Chromosome Protein-containing Complex
	Molecular Function	ATPase Activator Activity Double-stranded DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity	Bubble DNA Binding RNA Polymerase II Complex Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Protein Binding Enzyme Activator Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding
	Biological Process	DNA Repair Nucleotide-excision Repair Transcription By RNA Polymerase II DNA Damage Response	Double-strand Break Repair Via Homologous Recombination DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair DNA Recombination DNA Damage Response Response To UV Response To UV-C Negative Regulation Of Apoptotic Process
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Conotruncal heart defects (maternal effects) ( 28468790) Malaria ( 31844061) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 28991256) Ulcerative colitis ( 20848476)	Apolipoprotein A1 levels ( 32203549) Metabolite levels ( 23823483) Urinary calcium excretion ( 31993563)
Interacting Genes		13 interacting genes: EAF1 EIF1AD ERCC3 ERCC5 GTF2B GTF2E1 GTF2F1 POLR2A SREK1IP1 TBP TP53 UBC XBP1P1	12 interacting genes: BRCA1 BRCA2 ERCC2 ERCC6 EWSR1 GTF2H1 GTF2H4 HSPB1 NTHL1 PCNA POLR2A RAD51
Entrez ID		2968	2073
HPRD ID		03456	00595
Ensembl ID		ENSG00000213780	ENSG00000134899
Uniprot IDs		A0A1U9X7S4 Q92759	P28715
PDB IDs		5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVV 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	5EKF 5EKG 6TUR 6TUS 6TUW 6TUX 6VBH
Enriched GO Terms of Interacting Partners?		Transcription Factor TFIID Complex Transcription Initiation At RNA Polymerase II Promoter Promoter-specific Chromatin Binding DNA-templated Transcription Initiation DNA-templated Transcription RNA Polymerase II General Transcription Initiation Factor Activity Transcription Elongation By RNA Polymerase II Transcription By RNA Polymerase II DNA-templated Transcription Elongation Nucleobase-containing Compound Biosynthetic Process Nucleoplasm RNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Nucleotide-excision Repair RNA Polymerase II General Transcription Initiation Factor Binding MRNA Transcription Macromolecule Metabolic Process Transcription-coupled Nucleotide-excision Repair Transcription Preinitiation Complex Response To UV-C Nucleus Ubiquitin Protein Ligase Binding Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Nuclear Body Response To UV RNA Polymerase II Complex Binding 14-3-3 Protein Binding Protein-DNA Complex Assembly RNA Polymerase II-specific DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity Nucleotide-excision Repair Factor 3 Complex Transcriptional Start Site Selection At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly MRNA Transcription By RNA Polymerase II Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition DNA Binding Transcription Preinitiation Complex Assembly Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress P53 Binding Cellular Response To Diamide Damaged DNA Binding RNA Polymerase II Core Complex Assembly Transcription Factor TFIIE Complex TFIIF-class Transcription Factor Complex Binding Transcription Factor TFIIF Complex MRNA Metabolic Process	Nucleotide-excision Repair DNA Repair DNA Metabolic Process DNA Damage Response Nuclear Ubiquitin Ligase Complex Nucleic Acid Metabolic Process Transcription Factor TFIIH Core Complex Cellular Response To Stress Transcription Factor TFIIH Holo Complex Damaged DNA Binding Lateral Element Response To Radiation Nucleobase-containing Compound Metabolic Process Regulation Of DNA Damage Checkpoint Mitotic Recombination-dependent Replication Fork Processing Response To X-ray Nucleoplasm Transcription By RNA Polymerase II Response To Stress Response To Ionizing Radiation Replication Fork Processing Response To UV Cellular Response To Radiation Intrinsic Apoptotic Signaling Pathway Male Germ Cell Nucleus Response To Gamma Radiation DNA-templated Transcription DNA-templated Transcription Elongation Nucleus Regulation Of Cell Cycle Phase Transition Transcription Elongation By RNA Polymerase I Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA Metabolic Process Double-strand Break Repair Regulation Of DNA Repair DNA Binding Cellular Response To Ionizing Radiation Regulation Of Cellular Response To Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Transcription-coupled Nucleotide-excision Repair Positive Regulation Of DNA Metabolic Process DNA Repair Complex Telomere Maintenance Via Recombination Telomere Maintenance Apoptotic Signaling Pathway Response To Light Stimulus Chromosome ATP-dependent DNA Damage Sensor Activity RNA Polymerase Binding Mitotic Recombination
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