Description |
forkhead box P1 |
ribosomal protein S27a |
Image |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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- Translesion synthesis by REV1
- Recognition of DNA damage by PCNA-containing replication complex
- Translesion Synthesis by POLH
- Activation of NF-kappaB in B cells
- ISG15 antiviral mechanism
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- ER-Phagosome pathway
- Downregulation of ERBB4 signaling
- Spry regulation of FGF signaling
- Downregulation of ERBB2:ERBB3 signaling
- L13a-mediated translational silencing of Ceruloplasmin expression
- Peptide chain elongation
- Budding and maturation of HIV virion
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- DDX58/IFIH1-mediated induction of interferon-alpha/beta
- APC/C:Cdc20 mediated degradation of Cyclin B
- Autodegradation of Cdh1 by Cdh1:APC/C
- SCF-beta-TrCP mediated degradation of Emi1
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Membrane binding and targetting of GAG proteins
- Assembly Of The HIV Virion
- APC-Cdc20 mediated degradation of Nek2A
- SRP-dependent cotranslational protein targeting to membrane
- SRP-dependent cotranslational protein targeting to membrane
- Vpu mediated degradation of CD4
- Vif-mediated degradation of APOBEC3G
- EGFR downregulation
- SCF(Skp2)-mediated degradation of p27/p21
- Viral mRNA Translation
- Degradation of beta-catenin by the destruction complex
- TCF dependent signaling in response to WNT
- Downstream TCR signaling
- NRIF signals cell death from the nucleus
- p75NTR recruits signalling complexes
- NF-kB is activated and signals survival
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- NOTCH1 Intracellular Domain Regulates Transcription
- Activated NOTCH1 Transmits Signal to the Nucleus
- Activated NOTCH1 Transmits Signal to the Nucleus
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Selenocysteine synthesis
- Separation of Sister Chromatids
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- Oncogene Induced Senescence
- Regulation of PLK1 Activity at G2/M Transition
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Stimuli-sensing channels
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- FCERI mediated NF-kB activation
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- Regulation of innate immune responses to cytosolic DNA
- Glycogen synthesis
- Autodegradation of the E3 ubiquitin ligase COP1
- Deactivation of the beta-catenin transactivating complex
- Myoclonic epilepsy of Lafora
- ABC-family proteins mediated transport
- TAK1-dependent IKK and NF-kappa-B activation
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- Asymmetric localization of PCP proteins
- Degradation of AXIN
- Degradation of DVL
- Regulation of FZD by ubiquitination
- PINK1-PRKN Mediated Mitophagy
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Regulation of TNFR1 signaling
- TNFR1-induced NF-kappa-B signaling pathway
- Hedgehog ligand biogenesis
- Hh mutants are degraded by ERAD
- Dectin-1 mediated noncanonical NF-kB signaling
- CLEC7A (Dectin-1) signaling
- Degradation of GLI1 by the proteasome
- Degradation of GLI2 by the proteasome
- GLI3 is processed to GLI3R by the proteasome
- Hedgehog 'on' state
- Hedgehog 'on' state
- Negative regulation of FGFR1 signaling
- Negative regulation of FGFR2 signaling
- Negative regulation of FGFR3 signaling
- Negative regulation of FGFR4 signaling
- Translesion synthesis by POLK
- Translesion synthesis by POLI
- Termination of translesion DNA synthesis
- Regulation of RAS by GAPs
- TNFR2 non-canonical NF-kB pathway
- Negative regulation of MAPK pathway
- Regulation of necroptotic cell death
- NIK-->noncanonical NF-kB signaling
- Defective CFTR causes cystic fibrosis
- MAP3K8 (TPL2)-dependent MAPK1/3 activation
- HDR through Homologous Recombination (HRR)
- MAPK6/MAPK4 signaling
- UCH proteinases
- UCH proteinases
- Josephin domain DUBs
- Ub-specific processing proteases
- Ovarian tumor domain proteases
- Metalloprotease DUBs
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Processing of DNA double-strand break ends
- DNA Damage Recognition in GG-NER
- Formation of Incision Complex in GG-NER
- Gap-filling DNA repair synthesis and ligation in GG-NER
- Dual Incision in GG-NER
- Formation of TC-NER Pre-Incision Complex
- Transcription-Coupled Nucleotide Excision Repair (TC-NER)
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- Fanconi Anemia Pathway
- Major pathway of rRNA processing in the nucleolus and cytosol
- Regulation of TP53 Activity through Phosphorylation
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Methylation
- Negative regulation of MET activity
- Assembly of the pre-replicative complex
- Orc1 removal from chromatin
- CDK-mediated phosphorylation and removal of Cdc6
- Cyclin D associated events in G1
- G2/M Checkpoints
- Stabilization of p53
- Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
- Translation initiation complex formation
- Formation of a pool of free 40S subunits
- Formation of the ternary complex, and subsequently, the 43S complex
- Ribosomal scanning and start codon recognition
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Termination
- Ubiquitin-dependent degradation of Cyclin D
- PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
- The role of GTSE1 in G2/M progression after G2 checkpoint
- FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- Downregulation of ERBB2 signaling
- VLDLR internalisation and degradation
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- InlB-mediated entry of Listeria monocytogenes into host cell
- InlB-mediated entry of Listeria monocytogenes into host cell
- InlA-mediated entry of Listeria monocytogenes into host cells
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- Regulation of RUNX3 expression and activity
- Regulation of PTEN localization
- Regulation of PTEN stability and activity
- Neddylation
- ER Quality Control Compartment (ERQC)
- Regulation of expression of SLITs and ROBOs
- Regulation of expression of SLITs and ROBOs
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- TICAM1-dependent activation of IRF3/IRF7
- TICAM1,TRAF6-dependent induction of TAK1 complex
- Interleukin-1 signaling
- Peroxisomal protein import
- Peroxisomal protein import
- Interferon alpha/beta signaling
- Regulation of signaling by CBL
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Iron uptake and transport
- Negative regulators of DDX58/IFIH1 signaling
- Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
- IRAK1 recruits IKK complex
- IKK complex recruitment mediated by RIP1
- IRAK2 mediated activation of TAK1 complex
- TRAF6-mediated induction of TAK1 complex within TLR4 complex
- Negative regulation of NOTCH4 signaling
- Chaperone Mediated Autophagy
- Late endosomal microautophagy
- Response of EIF2AK4 (GCN2) to amino acid deficiency
- Prevention of phagosomal-lysosomal fusion
- Modulation by Mtb of host immune system
- Alpha-protein kinase 1 signaling pathway
- Aggrephagy
- Aggrephagy
- RAS processing
- Pexophagy
- Signaling by CSF1 (M-CSF) in myeloid cells
- Maturation of protein E
- SARS-CoV-1 activates/modulates innate immune responses
- Maturation of protein E
- Inactivation of CSF3 (G-CSF) signaling
- SARS-CoV-2 activates/modulates innate and adaptive immune responses
- Negative regulation of FLT3
- FLT3 signaling by CBL mutants
- Regulation of BACH1 activity
- Signaling by ALK fusions and activated point mutants
- SARS-CoV-1 modulates host translation machinery
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- SARS-CoV-2 modulates host translation machinery
- KEAP1-NFE2L2 pathway
- Regulation of NF-kappa B signaling
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
- Degradation of CDH1
- Amyloid fiber formation
- Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
- Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
- Antigen processing: Ubiquitination & Proteasome degradation
- Evasion by RSV of host interferon responses
- Regulation of pyruvate metabolism
- GSK3B-mediated proteasomal degradation of PD-L1(CD274)
- SPOP-mediated proteasomal degradation of PD-L1(CD274)
- AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
- PD-L1(CD274) glycosylation and translocation to plasma membrane
- Degradation of CRY and PER proteins
- Degradation of CRY and PER proteins
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
- PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
- ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
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Drugs |
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Diseases |
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GWAS |
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Interacting Genes |
117 interacting genes:
AKR1A1
ALB
ALYREF
ANLN
ANXA2
AURKA
BAZ2B
C1QBP
CCDC167
CCDC73
CDKN2AIP
CHSY1
CPSF6
CSDE1
CTBP1
DCD
DDX17
DDX19B
DLAT
DMD
DOC2A
ECE2
EXOG
FOXP2
FOXP4
GAPDH
GAR1
GOLGA2
H1-4
H2AC25
HERC1
HNRNPD
HNRNPH1
HNRNPK
HNRNPUL1
HSPA8
HSPB1
HYDIN
IGF2BP3
IKZF1
IL3RA
IQSEC2
KIF27
LRRK1
MNAT1
MTUS1
MYH7B
NCOR2
NLRC4
NR2F1
NR2F2
PARN
PCBP2
PCSK4
PKD1P6
POP7
PTBP1
PURA
RAG2
RAN
RBMS2
RBMX
RGL1
RPL22
RPL23A
RPL27
RPL28
RPL31
RPL35
RPL37A
RPL4
RPL5
RPL6
RPS15A
RPS16
RPS20
RPS27A
RPS3
RUVBL1
SATB1
SATB2
SLC22A16
SMARCA2
SNRPA1
SNRPB2
SNRPC
SNRPD1
SNRPD2
SNRPE
SNRPF
SNRPN
SOX5
SRP14
SRSF1
SRSF3
SRSF8
SSBP1
STAU1
STAU2
STRAP
TARBP2
TBC1D23
THUMPD1
TNFRSF1B
TRA2A
TUBA1B
TUBA8
TYW1B
UGGT1
UMPS
WBP11
WDR11
WDR72
YY1
ZC3HAV1
ZDHHC16
ZMYM2
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41 interacting genes:
ACVR1
APP
BACH1
BMPR1B
CALCOCO2
CDC6
CDK11B
DAZAP2
DESI1
DNAJB2
EPN2
EPN3
FAM168A
FOXP1
FSHR
GGA1
GGA3
KANSL3
LITAF
MAST2
MTURN
PAXIP1
PLEKHB2
PLSCR4
POLH
PTEN
RABGEF1
RAD23A
RBPMS
RNF11
RNF26
SMAD1
SMAD2
SMAD4
SMURF1
SMURF2
TGFBR1
TRAF6
UBQLN1
WBP2
ZNF512B
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Entrez ID |
27086 |
6233 |
HPRD ID |
18518 |
01878 |
Ensembl ID |
ENSG00000114861
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ENSG00000143947
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Uniprot IDs |
A0A0B4J2F3
A0A3B3IRW5
A0A3B3IST0
A0A3B3IT66
Q548T7
Q8N2P0
Q8TEA2
Q9H334
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B2RDW1
P62979
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PDB IDs |
2KIU
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2KHW
2KOX
2KTF
2KWU
2KWV
2L0F
2L0T
2XK5
3AXC
3I3T
3K9P
3N30
3N32
3NHE
3NOB
3NS8
3PHD
3PHW
3TBL
3VDZ
4R62
4UG0
4V6X
5A2Q
5AJ0
5FLX
5LKS
5T2C
5WVO
5YDK
6DC6
6FEC
6G18
6G51
6G53
6G5H
6G5I
6IP5
6IP6
6IP8
6J99
6KFP
6KG6
6KIU
6KIV
6KIW
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6SQO
6SQR
6SQS
6XA1
6Y0G
6Y57
6YBS
6Z6L
6Z6M
6Z6N
6ZLW
6ZM7
6ZME
6ZMI
6ZMO
6ZMT
6ZMW
6ZN5
6ZOJ
6ZOL
6ZON
6ZP4
6ZUO
6ZV6
6ZVH
6ZVJ
6ZXD
6ZXE
6ZXF
6ZXG
6ZXH
7A09
7BWD
7F0N
7JQB
7JQC
7K5I
7MQ9
7MQA
7OOJ
7QP6
7QP7
7R4X
7TQL
7WTT
7WTU
7WTV
7WTW
7WTX
7WTZ
7WU0
7XNY
8G5Y
8G60
8G61
8G6J
8GLP
8HTC
8HTF
8IFD
8IFE
8IVB
8K2C
8OZ0
8PJ1
8PJ2
8PJ3
8PJ4
8PJ5
8PJ6
8PPK
8PPL
8QOI
8T4S
8UKB
8X7I
8X7J
8XP2
8XP3
8XSX
8XSY
8XSZ
8XXL
8XXM
8XXN
8YOO
8YOP
8ZDB
8ZDC
8ZDD
9BKD
9BLN
9C3H
9G8M
9G8O
9IJU
9IML
9IPU
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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