FOXP1 and FOXP2

Number of citations of the paper that reports this interaction (PMID 14701752)
56

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		FOXP1	FOXP2
Gene Name		forkhead box P1	forkhead box P2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding Androgen Receptor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of B Cell Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Endothelial Cell Migration Osteoclast Differentiation Response To Lipopolysaccharide Regulation Of Tumor Necrosis Factor Production Chemokine (C-C Motif) Ligand 2 Secretion Osteoclast Development Macrophage Activation Monocyte Activation Endothelial Cell Activation Regulation Of Monocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Negative Regulation Of Androgen Receptor Signaling Pathway T Follicular Helper Cell Differentiation Interleukin-21 Secretion Regulation Of Defense Response To Bacterium Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Regulation Of Interleukin-12 Secretion	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mesenchymal Cell Proliferation Transcription, DNA-templated Skeletal Muscle Tissue Development Post-embryonic Development Cerebellum Development Caudate Nucleus Development Putamen Development Cerebral Cortex Development Growth Vocal Learning Camera-type Eye Development Negative Regulation Of Transcription, DNA-templated Lung Alveolus Development Smooth Muscle Tissue Development Righting Reflex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Pathways
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18821565) Subcutaneous adipose tissue ( 22589738)	Crohn's disease ( 22936669)
Protein-Protein Interactions		5 interactors: CTBP1 FOXP2 FOXP4 IL3RA NCOR2	13 interactors: AES CCNC CTBP1 CTBP2 FAM124A FOXP1 FOXP4 MAPK3 PIN1 RPIA SDCBP SP4 TSACC
Entrez ID		27086	93986
HPRD ID		18518	05611
Ensembl ID		ENSG00000114861	ENSG00000128573
Uniprot IDs		E9PFD3 Q548T7 Q8N2P0 Q8TEA2 Q9H334	B7ZLK5 O15409 Q8N6B5 Q8N6B6
PDB IDs		2KIU	2A07 2AS5
Enriched GO Terms of Interacting Partners?		White Fat Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Lung Development Respiratory Tube Development Respiratory System Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Lung Epithelial Cell Differentiation Lung Cell Differentiation Lung Epithelium Development Regulation Of Transcription From RNA Polymerase II Promoter Putamen Development Caudate Nucleus Development Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Tube Development Fat Cell Differentiation Negative Regulation Of Cellular Metabolic Process Interleukin-3-mediated Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Lung Goblet Cell Differentiation Vocal Learning Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Cellular Response To Interleukin-3 Righting Reflex Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Telencephalon Development RNA Metabolic Process Negative Regulation Of Histone H4 Acetylation Gene Expression Auditory Behavior Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Lung Secretory Cell Differentiation Striatum Development Forebrain Development Tissue Development Regulation Of Histone H4 Acetylation Mechanosensory Behavior Type I Pneumocyte Differentiation Response To Auditory Stimulus Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Heart Development	Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Lung Goblet Cell Differentiation Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Lung Secretory Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter White Fat Cell Differentiation Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Viral Genome Replication Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Epithelial Cell Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Binding Negative Regulation Of Biosynthetic Process Regulation Of Histone Acetylation Positive Regulation Of Metabolic Process Biosynthetic Process Negative Regulation Of Protein Binding Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Lung Epithelial Cell Differentiation Lung Cell Differentiation Lung Epithelium Development Interleukin-21 Secretion Negative Regulation Of Apolipoprotein Binding Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Positive Regulation Of Histone Modification Regulation Of Organelle Organization Axon Guidance Regulation Of Signal Transduction Response To Interleukin-1 Positive Regulation Of Organelle Organization
Tagcloud ?		3p amplifications breeding classic consuming cooperates costly daunting drive drivers driving endogenously engineering faithful hidden incurable pc pten ptenloxp rapidcap recreate reside rybp sensitized shq1 trp53 trp53loxp unmet validation	20p12 21q22 22q13 42e 6p21 7q31 aif1 ancestry cd crohn cumulative ep300 european exerted genotyped gwas ifngr2 intergenic likelihood loci macrod2 rbx1 representing rs4820425 southern spain suggestive top undiscovered
Tagcloud (Difference) ?		3p amplifications breeding classic consuming cooperates costly daunting drive drivers driving endogenously engineering faithful hidden incurable pc pten ptenloxp rapidcap recreate reside rybp sensitized shq1 trp53 trp53loxp unmet validation	20p12 21q22 22q13 42e 6p21 7q31 aif1 ancestry cd crohn cumulative ep300 european exerted genotyped gwas ifngr2 intergenic likelihood loci macrod2 rbx1 representing rs4820425 southern spain suggestive top undiscovered
Tagcloud (Intersection) ?