VAMP3 and VEGFD

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		VAMP3	VEGFD
Description		vesicle associated membrane protein 3	vascular endothelial growth factor D
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Cytosol Plasma Membrane Cell Surface Membrane Transport Vesicle Clathrin-coated Vesicle Secretory Granule Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Early Endosome Membrane Trans-Golgi Network Membrane Neuron Projection Intracellular Membrane-bounded Organelle Synapse Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen
	Molecular Function	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding	Platelet-derived Growth Factor Receptor Binding Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Chemoattractant Activity Identical Protein Binding Vascular Endothelial Growth Factor Receptor 3 Binding Receptor Ligand Activity
	Biological Process	Positive Regulation Of Receptor Recycling Positive Regulation Of Immunoglobulin Production Exocytosis Vesicle Docking Involved In Exocytosis Vesicle Fusion Protein Transport Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Substrate Adhesion-dependent Cell Spreading SNARE Complex Assembly Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Establishment Of Localization In Cell Membrane Fusion Protein-containing Complex Assembly Mucus Secretion Cellular Response To Type II Interferon Negative Regulation Of Secretion By Cell Regulation Of Histamine Secretion By Mast Cell	Angiogenesis Response To Hypoxia Sprouting Angiogenesis Positive Regulation Of Cell Population Proliferation Response To Bacterium Cell Differentiation Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Fibroblast Proliferation Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Mast Cell Chemotaxis Dopaminergic Neuron Differentiation
Pathways		ER-Phagosome pathway Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle	Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization
Drugs
Diseases			Gastric cancer
GWAS		Crohn's disease ( 21102463 28067908) DHEAS levels ( 34748635) Inflammatory bowel disease ( 28067908) Morning vs. evening chronotype ( 26835600) Periodontal microbiota ( 22699663) Ulcerative colitis ( 28067908)
Interacting Genes		63 interacting genes: ACAP1 AHNAK2 AIG1 APP AQP6 ARL13B BCAP31 BCL2L13 BIK BSCL2 BSND CD79A CIAO2A CLDN7 CLEC14A COMT DDB1 DNAJC5 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B GORAB GPX8 HSD17B13 IKBKG KCNK5 LHFPL5 LMNA MGST2 MGST3 NELFE NEMP1 PDZK1IP1 PLEKHO1 PTGES RETREG3 RMDN3 SAR1A SCN3B SLC10A1 SLC10A6 SLC16A2 SNAP23 STX16 STX1A STX2 STX3 STX4 TM4SF19 TM4SF20 TMEM237 TMEM31 TMEM35A TMEM52B TMEM86B TMPPE TMX2 VAMP2 VEGFD VSIR	4 interacting genes: FLT4 ITGA9 KDR VAMP3
Entrez ID		9341	2277
HPRD ID		04711	02102
Ensembl ID		ENSG00000049245	ENSG00000165197
Uniprot IDs		Q15836 Q6FGG2	O43915
PDB IDs			2XV7
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity SNARE Complex Vesicle Fusion Organelle Membrane Fusion SNARE Binding Protein Binding Organelle Fusion Glutathione Peroxidase Activity Membrane Fusion Vesicle Docking Exocytosis Organelle Localization By Membrane Tethering SNARE Complex Assembly Secretion By Cell Specific Granule Vesicle Organization Membrane Docking Endoplasmic Reticulum Membrane Signal Release Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Positive Regulation Of Protein Localization To Cell Surface Endomembrane System Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Endoplasmic Reticulum Secretion Membrane Organization Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Glutathione Transferase Activity Positive Regulation Of Synaptic Transmission Cornified Envelope Assembly Cellular Oxidant Detoxification Synaptic Vesicle Exocytosis ATP-dependent Protein Binding Prostanoid Metabolic Process Establishment Of Localization In Cell Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Vesicle-mediated Transport In Synapse Unsaturated Fatty Acid Metabolic Process Regulation Of Protein Localization To Cell Surface Icosanoid Metabolic Process Protein Transport Icosanoid Biosynthetic Process Plasma Membrane Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Glutathione Binding Cellular Detoxification Nuclear Envelope Lumen	Vascular Endothelial Growth Factor Receptor Activity Lymph Vessel Development Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Growth Factor Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Lung Alveolus Development Vasculature Development Positive Regulation Of Endothelial Cell Proliferation Cell Surface Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Protein Autophosphorylation Positive Regulation Of Endothelial Cell Migration Protein Tyrosine Kinase Activity Regulation Of Endothelial Cell Proliferation Integrin Alpha9-beta1 Complex Cell-substrate Adhesion Cell Migration Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Proliferation Receptor Complex Positive Regulation Of ERK1 And ERK2 Cascade Cell Motility Response To Hydrogen Sulfide Cellular Response To Hydrogen Sulfide Post-embryonic Camera-type Eye Morphogenesis Vascular Endothelial Growth Factor Binding Positive Regulation Of Protein Phosphorylation Integrin Binding Involved In Cell-matrix Adhesion Positive Regulation Of Nitric Oxide Mediated Signal Transduction Endocardium Development Positive Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of CGMP-mediated Signaling Blood Vessel Endothelial Cell Differentiation Sorting Endosome Post-embryonic Eye Morphogenesis Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Regulation Of Histamine Secretion By Mast Cell Tube Morphogenesis Angiogenesis Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Early Endosome Vascular Wound Healing Positive Regulation Of Mitochondrial Depolarization
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