VAMP3 and TMX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VAMP3	TMX2
Description		vesicle associated membrane protein 3	thioredoxin related transmembrane protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Cytosol Plasma Membrane Cell Surface Membrane Transport Vesicle Clathrin-coated Vesicle Secretory Granule Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Early Endosome Membrane Trans-Golgi Network Membrane Neuron Projection Intracellular Membrane-bounded Organelle Synapse Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site
	Molecular Function	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding	Protein Binding Disulfide Oxidoreductase Activity Identical Protein Binding
	Biological Process	Positive Regulation Of Receptor Recycling Positive Regulation Of Immunoglobulin Production Exocytosis Vesicle Docking Involved In Exocytosis Vesicle Fusion Protein Transport Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Substrate Adhesion-dependent Cell Spreading SNARE Complex Assembly Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Establishment Of Localization In Cell Membrane Fusion Protein-containing Complex Assembly Mucus Secretion Cellular Response To Type II Interferon Negative Regulation Of Secretion By Cell Regulation Of Histamine Secretion By Mast Cell	Brain Development
Pathways		ER-Phagosome pathway Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Crohn's disease ( 21102463 28067908) DHEAS levels ( 34748635) Inflammatory bowel disease ( 28067908) Morning vs. evening chronotype ( 26835600) Periodontal microbiota ( 22699663) Ulcerative colitis ( 28067908)	Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neuroticism ( 29255261) Problematic alcohol use ( 32451486) Reticulocyte count ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		63 interacting genes: ACAP1 AHNAK2 AIG1 APP AQP6 ARL13B BCAP31 BCL2L13 BIK BSCL2 BSND CD79A CIAO2A CLDN7 CLEC14A COMT DDB1 DNAJC5 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B GORAB GPX8 HSD17B13 IKBKG KCNK5 LHFPL5 LMNA MGST2 MGST3 NELFE NEMP1 PDZK1IP1 PLEKHO1 PTGES RETREG3 RMDN3 SAR1A SCN3B SLC10A1 SLC10A6 SLC16A2 SNAP23 STX16 STX1A STX2 STX3 STX4 TM4SF19 TM4SF20 TMEM237 TMEM31 TMEM35A TMEM52B TMEM86B TMPPE TMX2 VAMP2 VEGFD VSIR	163 interacting genes: AGPAT3 AGPAT4 AGPAT5 AIG1 AQP6 ARV1 ASGR1 ASPH ATXN1 BDKRB1 BET1 BNIP1 BNIP2 BNIP3 BRICD5 BTN2A2 C2CD2L CCDC167 CCL2 CD81 CDIPT CDS2 CMTM7 COL8A2 COMMD8 COX20 CTSA CTXN3 CXCL16 CXorf66 CYBC1 CYP4F2 DERL1 DGAT2L6 EMD EMP3 F2RL1 FA2H FAM177A1 FAM241B FAM3C FAXDC2 FDFT1 FUNDC2 FXYD6-FXYD2 GIMAP1 GIMAP5 GJB2 HACD2 HHATL HMOX1 HMOX2 HSD17B11 HSD17B13 HTATIP2 IER3 IER3IP1 IGFBP5 INSIG2 ITGAM LEPROT LEPROTL1 LHFPL5 LRAT MALL MFF MGLL MGST3 MIP MLN MS4A1 MTNR1A NAT8 NDUFA3 NINJ2 NRM NSDHL NSG1 ORMDL2 OTULINL PAEP PEDS1-UBE2V1 PEX16 PKMYT1 PLP2 PNLIPRP1 PRAF2 PRB1 PTAFR PTPN9 RABAC1 REEP2 REEP4 RFT1 RNF24 RTP2 RUSF1 SACM1L SCAMP5 SCD SELENOK SERF1A SERF1B SERP2 SFT2D1 SFXN1 SFXN3 SLC22A2 SLC29A2 SLC35A1 SLC67A1 SLC71A2 SMAGP SMCO4 SMIM1 STATH STX12 STX3 STX7 THBD THSD7B TMBIM6 TMEM115 TMEM120A TMEM120B TMEM121 TMEM128 TMEM140 TMEM14B TMEM14C TMEM176A TMEM201 TMEM203 TMEM208 TMEM222 TMEM239 TMEM254 TMEM31 TMEM50B TMEM51 TMEM65 TMEM71 TMEM86B TMEM97 TPRG1 TRAM1L1 TREX1 TSNARE1 TSPAN2 TVP23B UBE2J1 UNC93A VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB WFDC2 YIF1A YIPF1 YIPF2 YIPF6
Entrez ID		9341	51075
HPRD ID		04711	07159
Ensembl ID		ENSG00000049245	ENSG00000213593
Uniprot IDs		Q15836 Q6FGG2	Q9Y320
PDB IDs			2DJ0
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity SNARE Complex Vesicle Fusion Organelle Membrane Fusion SNARE Binding Protein Binding Organelle Fusion Glutathione Peroxidase Activity Membrane Fusion Vesicle Docking Exocytosis Organelle Localization By Membrane Tethering SNARE Complex Assembly Secretion By Cell Specific Granule Vesicle Organization Membrane Docking Endoplasmic Reticulum Membrane Signal Release Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Positive Regulation Of Protein Localization To Cell Surface Endomembrane System Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Endoplasmic Reticulum Secretion Membrane Organization Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Glutathione Transferase Activity Positive Regulation Of Synaptic Transmission Cornified Envelope Assembly Cellular Oxidant Detoxification Synaptic Vesicle Exocytosis ATP-dependent Protein Binding Prostanoid Metabolic Process Establishment Of Localization In Cell Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Vesicle-mediated Transport In Synapse Unsaturated Fatty Acid Metabolic Process Regulation Of Protein Localization To Cell Surface Icosanoid Metabolic Process Protein Transport Icosanoid Biosynthetic Process Plasma Membrane Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Glutathione Binding Cellular Detoxification Nuclear Envelope Lumen	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNARE Complex SNAP Receptor Activity Cortical Endoplasmic Reticulum Protein Binding CDP-diacylglycerol Metabolic Process Vesicle-mediated Transport Lipid Biosynthetic Process Membrane Organization Nuclear Envelope Endomembrane System Membrane Docking CDP-diacylglycerol Biosynthetic Process Organelle Fusion Organelle Membrane Fusion Intracellular Transport Lipid Metabolic Process Organelle Localization By Membrane Tethering Golgi Membrane Membrane Fusion Endoplasmic Reticulum Organization Cellular Localization Establishment Of Localization In Cell Sterol Biosynthetic Process Vesicle Fusion Golgi Trans Cisterna Golgi Medial Cisterna Golgi Vesicle Transport Heme Oxidation Heme Oxygenase (decyclizing) Activity Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Nuclear Inner Membrane Response To Oxygen-glucose Deprivation Regulation Of Cellular Localization Amyloid Fibril Formation Mitochondrial Outer Membrane Steroid Biosynthetic Process Monoatomic Ion Transmembrane Transporter Activity SNARE Complex Assembly Glycerolipid Metabolic Process FFAT Motif Binding Steroid Dehydrogenase Activity Serine Import Into Mitochondrion Vesicle Docking Golgi Apparatus Heme Metabolic Process Spindle Pole Centrosome Cholesterol Biosynthetic Process
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