VAMP3 and EBP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VAMP3	EBP
Description		vesicle associated membrane protein 3	EBP cholestenol delta-isomerase
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Cytosol Plasma Membrane Cell Surface Membrane Transport Vesicle Clathrin-coated Vesicle Secretory Granule Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Early Endosome Membrane Trans-Golgi Network Membrane Neuron Projection Intracellular Membrane-bounded Organelle Synapse Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Nuclear Membrane
	Molecular Function	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding	C-8 Sterol Isomerase Activity Steroid Delta-isomerase Activity Protein Binding Hydrolase Activity Isomerase Activity Cholesterol-5,6-oxide Hydrolase Activity Identical Protein Binding Cholestenol Delta-isomerase Activity
	Biological Process	Positive Regulation Of Receptor Recycling Positive Regulation Of Immunoglobulin Production Exocytosis Vesicle Docking Involved In Exocytosis Vesicle Fusion Protein Transport Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Substrate Adhesion-dependent Cell Spreading SNARE Complex Assembly Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Establishment Of Localization In Cell Membrane Fusion Protein-containing Complex Assembly Mucus Secretion Cellular Response To Type II Interferon Negative Regulation Of Secretion By Cell Regulation Of Histamine Secretion By Mast Cell	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Sterol Biosynthetic Process Hemopoiesis Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Biosynthetic Process Via Lathosterol Ossification Involved In Bone Maturation
Pathways		ER-Phagosome pathway Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle	Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol
Drugs			Tamoxifen
Diseases
GWAS		Crohn's disease ( 21102463 28067908) DHEAS levels ( 34748635) Inflammatory bowel disease ( 28067908) Morning vs. evening chronotype ( 26835600) Periodontal microbiota ( 22699663) Ulcerative colitis ( 28067908)
Interacting Genes		63 interacting genes: ACAP1 AHNAK2 AIG1 APP AQP6 ARL13B BCAP31 BCL2L13 BIK BSCL2 BSND CD79A CIAO2A CLDN7 CLEC14A COMT DDB1 DNAJC5 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B GORAB GPX8 HSD17B13 IKBKG KCNK5 LHFPL5 LMNA MGST2 MGST3 NELFE NEMP1 PDZK1IP1 PLEKHO1 PTGES RETREG3 RMDN3 SAR1A SCN3B SLC10A1 SLC10A6 SLC16A2 SNAP23 STX16 STX1A STX2 STX3 STX4 TM4SF19 TM4SF20 TMEM237 TMEM31 TMEM35A TMEM52B TMEM86B TMPPE TMX2 VAMP2 VEGFD VSIR	172 interacting genes: ABHD16A ANKRD46 APP AQP6 ARL13B ARL6IP6 ARLN ARV1 ATP13A1 BMP10 BNIP3 BTN2A2 C2 C2CD2L C5 C5orf46 CCDC167 CCL4L2 CD40 CD69 CD81 CDIPT CHODL CLDND2 CREB3 CREB3L1 CYB561 CYB5B CYP4F2 DEFB103A DEFB103B DEFB127 DNAJC30 EBPL EMC6 EMP1 ERG28 ERGIC3 ESRRG FA2H FAM209A FAXDC2 FCER1G FETUB FIS1 FKBP8 FUNDC2 FXYD3 FXYD6 GIMAP1 GIMAP5 GJB2 GJB6 GLP1R GOSR2 GPR152 HMOX2 HSD17B13 IER3IP1 INSIG2 JAGN1 LDLRAD1 LEMD1 LPCAT2 LRP10 LRRC59 LTC4S MFSD6 MITF MMP14 MS4A13 MTNR1B NAT8 NDUFA3 NDUFB11 NEU1 NINJ1 NINJ2 NKG7 ODF4 ORMDL1 ORMDL2 ORMDL3 OTOP3 PLLP PLP2 PLPP6 PMP22 PNLIPRP1 PTPN9 PVR RNF152 RTP2 RUSF1 SACM1L SCAMP4 SEC22B SERP1 SERP2 SFXN5 SLC10A6 SLC35G1 SLC3A2 SLC41A2 SMAGP SMCO4 SMIM1 SMIM3 SNORC STX12 STX1B STX5 STX6 STX7 STX8 SYNGR1 SYNJ2BP SYS1 TBC1D20 THBD TIMM23 TLCD1 TLCD4 TMBIM6 TMEM100 TMEM11 TMEM120B TMEM140 TMEM147 TMEM14B TMEM14C TMEM167B TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM239 TMEM242 TMEM243 TMEM254 TMEM31 TMEM42 TMEM51 TMEM60 TMEM65 TMEM86A TMEM86B TMEM97 TMIE TRARG1 TREX1 TSNARE1 TSPO2 UBE2J1 UBIAD1 UNC50 UNC93B1 USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAPA VAPB VMA12 YIF1A YIPF1 YIPF4 YIPF6 ZDHHC24 ZFPL1
Entrez ID		9341	10682
HPRD ID		04711	02192
Ensembl ID		ENSG00000049245	ENSG00000147155
Uniprot IDs		Q15836 Q6FGG2	A0A024QYX0 Q15125
PDB IDs			6OHT 6OHU 8W0R 8W0S
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity SNARE Complex Vesicle Fusion Organelle Membrane Fusion SNARE Binding Protein Binding Organelle Fusion Glutathione Peroxidase Activity Membrane Fusion Vesicle Docking Exocytosis Organelle Localization By Membrane Tethering SNARE Complex Assembly Secretion By Cell Specific Granule Vesicle Organization Membrane Docking Endoplasmic Reticulum Membrane Signal Release Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Positive Regulation Of Protein Localization To Cell Surface Endomembrane System Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Endoplasmic Reticulum Secretion Membrane Organization Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Glutathione Transferase Activity Positive Regulation Of Synaptic Transmission Cornified Envelope Assembly Cellular Oxidant Detoxification Synaptic Vesicle Exocytosis ATP-dependent Protein Binding Prostanoid Metabolic Process Establishment Of Localization In Cell Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Vesicle-mediated Transport In Synapse Unsaturated Fatty Acid Metabolic Process Regulation Of Protein Localization To Cell Surface Icosanoid Metabolic Process Protein Transport Icosanoid Biosynthetic Process Plasma Membrane Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Glutathione Binding Cellular Detoxification Nuclear Envelope Lumen	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Protein Binding Membrane Fusion Vesicle-mediated Transport Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Membrane Organization Golgi Vesicle Transport Endomembrane System Cellular Localization Organelle Localization By Membrane Tethering SNARE Binding Vesicle Organization Membrane Docking Establishment Of Protein Localization Vesicle Docking Intracellular Transport Golgi Membrane Establishment Of Localization In Cell Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane SNARE Complex Assembly Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Secretion By Cell Chemical Homeostasis Negative Regulation Of Sphingolipid Biosynthetic Process Protein Transport Serine Palmitoyltransferase Complex Exocytosis Establishment Of Protein Localization To Membrane Endoplasmic Reticulum Unfolded Protein Response Sterol Biosynthetic Process Transport Vesicle Regulation Of Cellular Localization Alkenylglycerophosphocholine Hydrolase Activity Intracellular Chemical Homeostasis Host-mediated Activation Of Viral Genome Replication Golgi Apparatus Syntaxin Binding Nuclear Inner Membrane Host-mediated Perturbation Of Viral Genome Replication Sphingomyelin Biosynthetic Process Intracellular Protein Localization Phagocytic Vesicle
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