VAPA and RMDN2

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology)

		VAPA	RMDN2
Description		VAMP associated protein A	regulator of microtubule dynamics 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Bicellular Tight Junction Microtubule Cytoskeleton Membrane Nuclear Membrane Vesicle Azurophil Granule Membrane Perinuclear Region Of Cytoplasm Anchoring Junction Endoplasmic Reticulum Exit Site	Spindle Pole Cytoplasm Mitochondrion Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Membrane Mitotic Spindle Mitotic Spindle Pole
	Molecular Function	Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Cadherin Binding Protein Heterodimerization Activity	Protein Binding Microtubule Binding
	Biological Process	Sphingomyelin Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Phospholipid Transport Sterol Transport Viral Release From Host Cell Cholesterol Transport Neuron Projection Development Protein Folding In Endoplasmic Reticulum Ceramide Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Membrane Fusion Endoplasmic Reticulum-plasma Membrane Tethering Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Peak expiratory flow ( 30804560) Pulmonary function (smoking interaction) ( 23284291)	Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Cutaneous malignant melanoma ( 26237428) Eosinophil count ( 32888494) Melanoma ( 28212542)
Interacting Genes		47 interacting genes: ADGRG7 ADRB2 APOD AQP6 BIK CACNG1 CD79A CFTR CYB561 CYBRD1 EBAG9 EBP EGFR ERBB2 GKN1 HSD17B13 JAGN1 KCNB1 KCNB2 LEPROTL1 NSF NXF1 OCIAD1 OPRM1 OSBP RB1CC1 RETREG3 RMDN2 RMDN3 SCN3B SEC11C SIK1 SLC16A7 SLC18A1 SLC35B1 SNX2 STARD3 TMEM229B TMEM35A TMEM86B TMIE TMX2 USP20 USP40 VAMP1 VAMP2 ZBTB22	14 interacting genes: AGTRAP CMTM5 DIABLO HSD17B11 LMNA RDH10 RTN3 SAR1A STX1A THAP4 TNFRSF10D VAPA VAPB VEZT
Entrez ID		9218	151393
HPRD ID		09299	08741
Ensembl ID		ENSG00000101558	ENSG00000115841
Uniprot IDs		Q9P0L0	A0A0C4DFM4 Q96LZ7
PDB IDs		2RR3 6TQR
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Ascorbate Homeostasis Clathrin-coated Endocytic Vesicle Membrane Protein Localization To Cell Periphery Transmembrane Monodehydroascorbate Reductase Activity Regulation Of Cellular Localization Organic Hydroxy Compound Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Regulation Of Establishment Of Protein Localization Cellular Localization Endosome Establishment Of Localization In Cell Regulation Of Protein Localization Regulation Of Protein Transport Transmembrane Transport Monoatomic Ion Transport Protein Localization To Membrane Protein Localization To Plasma Membrane ERBB2-EGFR Signaling Pathway Potassium Channel Regulator Activity Negative Regulation Of Protein Transport Syntaxin Binding Monoatomic Ion Channel Complex Organelle Membrane Contact Site Cytoplasmic Vesicle SNARE Complex Assembly Inorganic Ion Transmembrane Transport Localization Within Membrane Negative Regulation Of Establishment Of Protein Localization Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Hormone Secretion Regulation Of Protein Secretion SNARE Binding Regulation Of Transport Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Monoatomic Cation Transport Cholesterol Transport Regulation Of Secretion By Cell Vesicle-mediated Transport Endosome Membrane Metal Ion Transport Negative Regulation Of Protein Secretion Syntaxin-1 Binding Protein Binding Regulation Of Insulin Secretion Inorganic Cation Transmembrane Transport	FFAT Motif Binding Endoplasmic Reticulum Exit Site Membrane Organization COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Endoplasmic Reticulum Localization Endoplasmic Reticulum Organization Organelle Localization By Membrane Tethering Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral Genome Replication Membrane Docking Host-mediated Suppression Of Viral Genome Replication Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Vesicle Organization Endoplasmic Reticulum Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Myosin Binding Viral Release From Host Cell Vesicle Budding From Membrane Protein-membrane Adaptor Activity Organelle Localization Host-mediated Activation Of Viral Process Myosin Head/neck Binding Peroxynitrite Isomerase Activity Primary Lung Bud Formation Positive Regulation Of Retinoic Acid Biosynthetic Process Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Nuclear Membrane Cholesterol Transport Golgi Vesicle Transport DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation By Virus Of Viral Protein Levels In Host Cell Amino Acid Sensor Activity Vesicle-mediated Transport Host-mediated Perturbation Of Viral Process Intracellular Transport Sterol Transport Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Nitrate Metabolic Process Steroid Dehydrogenase Activity Lipid Droplet Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Angiotensin Type II Receptor Activity Regulation Of Isoprenoid Metabolic Process Host-mediated Perturbation Of Symbiont Process
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