VAPA and KCNB1

Number of citations of the paper that reports this interaction (PubMedID 34312846)
0

Data Source:
BioGRID (unspecified method, unspecified method)

		VAPA	KCNB1
Description		VAMP associated protein A	potassium voltage-gated channel subfamily B member 1
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Bicellular Tight Junction Microtubule Cytoskeleton Membrane Nuclear Membrane Vesicle Azurophil Granule Membrane Perinuclear Region Of Cytoplasm Anchoring Junction Endoplasmic Reticulum Exit Site	Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Apical Plasma Membrane Lateral Plasma Membrane Axon Dendrite Dendrite Membrane Neuronal Cell Body Membrane Monoatomic Ion Channel Complex Sarcolemma Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Cholinergic Synapse Postsynaptic Specialization Membrane Proximal Dendrite
	Molecular Function	Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Cadherin Binding Protein Heterodimerization Activity	SNARE Binding Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Channel Regulator Activity Transmembrane Transporter Binding Protein Heterodimerization Activity
	Biological Process	Sphingomyelin Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Phospholipid Transport Sterol Transport Viral Release From Host Cell Cholesterol Transport Neuron Projection Development Protein Folding In Endoplasmic Reticulum Ceramide Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Membrane Fusion Endoplasmic Reticulum-plasma Membrane Tethering Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding	Action Potential Monoatomic Ion Transport Potassium Ion Transport Exocytosis Vesicle Docking Involved In Exocytosis Glutamate Receptor Signaling Pathway Positive Regulation Of Norepinephrine Secretion Cellular Response To Nutrient Levels Positive Regulation Of Catecholamine Secretion Monoatomic Ion Transmembrane Transport Glucose Homeostasis Clustering Of Voltage-gated Potassium Channels Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Response To Axon Injury Protein Homooligomerization Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Potassium Ion Export Across Plasma Membrane Regulation Of Action Potential Positive Regulation Of Long-term Synaptic Depression Response To L-glutamate Regulation Of Motor Neuron Apoptotic Process
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Drugs			Enflurane Promethazine Miconazole Dalfampridine
Diseases
GWAS		Diverticular disease ( 30177863) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Peak expiratory flow ( 30804560) Pulmonary function (smoking interaction) ( 23284291)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 34002096) Diastolic blood pressure ( 30224653) Height ( 28552196) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) White matter hyperintensity burden ( 25663218)
Interacting Genes		47 interacting genes: ADGRG7 ADRB2 APOD AQP6 BIK CACNG1 CD79A CFTR CYB561 CYBRD1 EBAG9 EBP EGFR ERBB2 GKN1 HSD17B13 JAGN1 KCNB1 KCNB2 LEPROTL1 NSF NXF1 OCIAD1 OPRM1 OSBP RB1CC1 RETREG3 RMDN2 RMDN3 SCN3B SEC11C SIK1 SLC16A7 SLC18A1 SLC35B1 SNX2 STARD3 TMEM229B TMEM35A TMEM86B TMIE TMX2 USP20 USP40 VAMP1 VAMP2 ZBTB22	19 interacting genes: CALM1 KCNB2 KCNE5 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNS3 KCNV1 KCNV2 NEDD4L PTK2 PTPRE SNAP25 SRC STX1A VAPA VAPB
Entrez ID		9218	3745
HPRD ID		09299	08983
Ensembl ID		ENSG00000101558	ENSG00000158445
Uniprot IDs		Q9P0L0	Q14721
PDB IDs		2RR3 6TQR	7RE5 7SPD
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Ascorbate Homeostasis Clathrin-coated Endocytic Vesicle Membrane Protein Localization To Cell Periphery Transmembrane Monodehydroascorbate Reductase Activity Regulation Of Cellular Localization Organic Hydroxy Compound Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Regulation Of Establishment Of Protein Localization Cellular Localization Endosome Establishment Of Localization In Cell Regulation Of Protein Localization Regulation Of Protein Transport Transmembrane Transport Monoatomic Ion Transport Protein Localization To Membrane Protein Localization To Plasma Membrane ERBB2-EGFR Signaling Pathway Potassium Channel Regulator Activity Negative Regulation Of Protein Transport Syntaxin Binding Monoatomic Ion Channel Complex Organelle Membrane Contact Site Cytoplasmic Vesicle SNARE Complex Assembly Inorganic Ion Transmembrane Transport Localization Within Membrane Negative Regulation Of Establishment Of Protein Localization Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Hormone Secretion Regulation Of Protein Secretion SNARE Binding Regulation Of Transport Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Monoatomic Cation Transport Cholesterol Transport Regulation Of Secretion By Cell Vesicle-mediated Transport Endosome Membrane Metal Ion Transport Negative Regulation Of Protein Secretion Syntaxin-1 Binding Protein Binding Regulation Of Insulin Secretion Inorganic Cation Transmembrane Transport	Voltage-gated Potassium Channel Complex Voltage-gated Potassium Channel Activity Potassium Channel Regulator Activity Regulation Of Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Transport Action Potential Potassium Channel Activity Monoatomic Ion Channel Complex Monoatomic Ion Channel Activity Metal Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Ion Transmembrane Transport Regulation Of Biological Quality Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Plasma Membrane Protein Homooligomerization Monoatomic Ion Transport Regulation Of Potassium Ion Transmembrane Transport Protein Complex Oligomerization Transmembrane Transport Protein-containing Complex Assembly Regulation Of Metal Ion Transport Protein-containing Complex Organization Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Delayed Rectifier Potassium Channel Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Organelle Localization By Membrane Tethering Membrane Docking Regulation Of Transport Membrane Cellular Component Assembly FFAT Motif Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Caveolin-mediated Endocytosis Endoplasmic Reticulum Localization Signal Complex Assembly Host-mediated Activation Of Viral Genome Replication Negative Regulation Of Cation Transmembrane Transport Host-mediated Perturbation Of Viral Genome Replication Negative Regulation Of Monoatomic Ion Transmembrane Transport Synaptic Vesicle Docking
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