VAPA and TMX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VAPA	TMX2
Description		VAMP associated protein A	thioredoxin related transmembrane protein 2
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Bicellular Tight Junction Microtubule Cytoskeleton Membrane Nuclear Membrane Vesicle Azurophil Granule Membrane Perinuclear Region Of Cytoplasm Anchoring Junction Endoplasmic Reticulum Exit Site	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site
	Molecular Function	Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Cadherin Binding Protein Heterodimerization Activity	Protein Binding Disulfide Oxidoreductase Activity Identical Protein Binding
	Biological Process	Sphingomyelin Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Phospholipid Transport Sterol Transport Viral Release From Host Cell Cholesterol Transport Neuron Projection Development Protein Folding In Endoplasmic Reticulum Ceramide Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Membrane Fusion Endoplasmic Reticulum-plasma Membrane Tethering Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding	Brain Development
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Peak expiratory flow ( 30804560) Pulmonary function (smoking interaction) ( 23284291)	Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neuroticism ( 29255261) Problematic alcohol use ( 32451486) Reticulocyte count ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		47 interacting genes: ADGRG7 ADRB2 APOD AQP6 BIK CACNG1 CD79A CFTR CYB561 CYBRD1 EBAG9 EBP EGFR ERBB2 GKN1 HSD17B13 JAGN1 KCNB1 KCNB2 LEPROTL1 NSF NXF1 OCIAD1 OPRM1 OSBP RB1CC1 RETREG3 RMDN2 RMDN3 SCN3B SEC11C SIK1 SLC16A7 SLC18A1 SLC35B1 SNX2 STARD3 TMEM229B TMEM35A TMEM86B TMIE TMX2 USP20 USP40 VAMP1 VAMP2 ZBTB22	163 interacting genes: AGPAT3 AGPAT4 AGPAT5 AIG1 AQP6 ARV1 ASGR1 ASPH ATXN1 BDKRB1 BET1 BNIP1 BNIP2 BNIP3 BRICD5 BTN2A2 C2CD2L CCDC167 CCL2 CD81 CDIPT CDS2 CMTM7 COL8A2 COMMD8 COX20 CTSA CTXN3 CXCL16 CXorf66 CYBC1 CYP4F2 DERL1 DGAT2L6 EMD EMP3 F2RL1 FA2H FAM177A1 FAM241B FAM3C FAXDC2 FDFT1 FUNDC2 FXYD6-FXYD2 GIMAP1 GIMAP5 GJB2 HACD2 HHATL HMOX1 HMOX2 HSD17B11 HSD17B13 HTATIP2 IER3 IER3IP1 IGFBP5 INSIG2 ITGAM LEPROT LEPROTL1 LHFPL5 LRAT MALL MFF MGLL MGST3 MIP MLN MS4A1 MTNR1A NAT8 NDUFA3 NINJ2 NRM NSDHL NSG1 ORMDL2 OTULINL PAEP PEDS1-UBE2V1 PEX16 PKMYT1 PLP2 PNLIPRP1 PRAF2 PRB1 PTAFR PTPN9 RABAC1 REEP2 REEP4 RFT1 RNF24 RTP2 RUSF1 SACM1L SCAMP5 SCD SELENOK SERF1A SERF1B SERP2 SFT2D1 SFXN1 SFXN3 SLC22A2 SLC29A2 SLC35A1 SLC67A1 SLC71A2 SMAGP SMCO4 SMIM1 STATH STX12 STX3 STX7 THBD THSD7B TMBIM6 TMEM115 TMEM120A TMEM120B TMEM121 TMEM128 TMEM140 TMEM14B TMEM14C TMEM176A TMEM201 TMEM203 TMEM208 TMEM222 TMEM239 TMEM254 TMEM31 TMEM50B TMEM51 TMEM65 TMEM71 TMEM86B TMEM97 TPRG1 TRAM1L1 TREX1 TSNARE1 TSPAN2 TVP23B UBE2J1 UNC93A VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB WFDC2 YIF1A YIPF1 YIPF2 YIPF6
Entrez ID		9218	51075
HPRD ID		09299	07159
Ensembl ID		ENSG00000101558	ENSG00000213593
Uniprot IDs		Q9P0L0	Q9Y320
PDB IDs		2RR3 6TQR	2DJ0
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Ascorbate Homeostasis Clathrin-coated Endocytic Vesicle Membrane Protein Localization To Cell Periphery Transmembrane Monodehydroascorbate Reductase Activity Regulation Of Cellular Localization Organic Hydroxy Compound Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Regulation Of Establishment Of Protein Localization Cellular Localization Endosome Establishment Of Localization In Cell Regulation Of Protein Localization Regulation Of Protein Transport Transmembrane Transport Monoatomic Ion Transport Protein Localization To Membrane Protein Localization To Plasma Membrane ERBB2-EGFR Signaling Pathway Potassium Channel Regulator Activity Negative Regulation Of Protein Transport Syntaxin Binding Monoatomic Ion Channel Complex Organelle Membrane Contact Site Cytoplasmic Vesicle SNARE Complex Assembly Inorganic Ion Transmembrane Transport Localization Within Membrane Negative Regulation Of Establishment Of Protein Localization Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Hormone Secretion Regulation Of Protein Secretion SNARE Binding Regulation Of Transport Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Monoatomic Cation Transport Cholesterol Transport Regulation Of Secretion By Cell Vesicle-mediated Transport Endosome Membrane Metal Ion Transport Negative Regulation Of Protein Secretion Syntaxin-1 Binding Protein Binding Regulation Of Insulin Secretion Inorganic Cation Transmembrane Transport	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNARE Complex SNAP Receptor Activity Cortical Endoplasmic Reticulum Protein Binding CDP-diacylglycerol Metabolic Process Vesicle-mediated Transport Lipid Biosynthetic Process Membrane Organization Nuclear Envelope Endomembrane System Membrane Docking CDP-diacylglycerol Biosynthetic Process Organelle Fusion Organelle Membrane Fusion Intracellular Transport Lipid Metabolic Process Organelle Localization By Membrane Tethering Golgi Membrane Membrane Fusion Endoplasmic Reticulum Organization Cellular Localization Establishment Of Localization In Cell Sterol Biosynthetic Process Vesicle Fusion Golgi Trans Cisterna Golgi Medial Cisterna Golgi Vesicle Transport Heme Oxidation Heme Oxygenase (decyclizing) Activity Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Nuclear Inner Membrane Response To Oxygen-glucose Deprivation Regulation Of Cellular Localization Amyloid Fibril Formation Mitochondrial Outer Membrane Steroid Biosynthetic Process Monoatomic Ion Transmembrane Transporter Activity SNARE Complex Assembly Glycerolipid Metabolic Process FFAT Motif Binding Steroid Dehydrogenase Activity Serine Import Into Mitochondrion Vesicle Docking Golgi Apparatus Heme Metabolic Process Spindle Pole Centrosome Cholesterol Biosynthetic Process
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