VAPA and KCNB2

Number of citations of the paper that reports this interaction (PubMedID 34312846)
0

Data Source:
BioGRID (unspecified method)

		VAPA	KCNB2
Description		VAMP associated protein A	potassium voltage-gated channel subfamily B member 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Bicellular Tight Junction Microtubule Cytoskeleton Membrane Nuclear Membrane Vesicle Azurophil Granule Membrane Perinuclear Region Of Cytoplasm Anchoring Junction Endoplasmic Reticulum Exit Site	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Dendrite Neuronal Cell Body Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Perikaryon
	Molecular Function	Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Cadherin Binding Protein Heterodimerization Activity	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Protein Heterodimerization Activity
	Biological Process	Sphingomyelin Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Phospholipid Transport Sterol Transport Viral Release From Host Cell Cholesterol Transport Neuron Projection Development Protein Folding In Endoplasmic Reticulum Ceramide Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Membrane Fusion Endoplasmic Reticulum-plasma Membrane Tethering Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding	Action Potential Monoatomic Ion Transport Potassium Ion Transport Regulation Of Smooth Muscle Contraction Monoatomic Ion Transmembrane Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Voltage gated Potassium channels
Drugs			Enflurane Promethazine Miconazole Dalfampridine
Diseases
GWAS		Diverticular disease ( 30177863) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Peak expiratory flow ( 30804560) Pulmonary function (smoking interaction) ( 23284291)	Adult body size ( 32376654) Chronotype ( 30696823) Cognitive performance ( 20125193) Coronary artery disease in type 1 diabetes ( 29695241) Crohn's disease ( 22412388) Echocardiographic traits ( 17903301) HDL cholesterol levels ( 32203549) Multiple sclerosis (age of onset) ( 19010793) Tea consumption ( 31046077) Type 2 diabetes ( 32499647)
Interacting Genes		47 interacting genes: ADGRG7 ADRB2 APOD AQP6 BIK CACNG1 CD79A CFTR CYB561 CYBRD1 EBAG9 EBP EGFR ERBB2 GKN1 HSD17B13 JAGN1 KCNB1 KCNB2 LEPROTL1 NSF NXF1 OCIAD1 OPRM1 OSBP RB1CC1 RETREG3 RMDN2 RMDN3 SCN3B SEC11C SIK1 SLC16A7 SLC18A1 SLC35B1 SNX2 STARD3 TMEM229B TMEM35A TMEM86B TMIE TMX2 USP20 USP40 VAMP1 VAMP2 ZBTB22	4 interacting genes: KCNB1 KCNG3 KCNV1 VAPA
Entrez ID		9218	9312
HPRD ID		09299	09666
Ensembl ID		ENSG00000101558	ENSG00000182674
Uniprot IDs		Q9P0L0	Q92953
PDB IDs		2RR3 6TQR
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Ascorbate Homeostasis Clathrin-coated Endocytic Vesicle Membrane Protein Localization To Cell Periphery Transmembrane Monodehydroascorbate Reductase Activity Regulation Of Cellular Localization Organic Hydroxy Compound Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Regulation Of Establishment Of Protein Localization Cellular Localization Endosome Establishment Of Localization In Cell Regulation Of Protein Localization Regulation Of Protein Transport Transmembrane Transport Monoatomic Ion Transport Protein Localization To Membrane Protein Localization To Plasma Membrane ERBB2-EGFR Signaling Pathway Potassium Channel Regulator Activity Negative Regulation Of Protein Transport Syntaxin Binding Monoatomic Ion Channel Complex Organelle Membrane Contact Site Cytoplasmic Vesicle SNARE Complex Assembly Inorganic Ion Transmembrane Transport Localization Within Membrane Negative Regulation Of Establishment Of Protein Localization Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Hormone Secretion Regulation Of Protein Secretion SNARE Binding Regulation Of Transport Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Monoatomic Cation Transport Cholesterol Transport Regulation Of Secretion By Cell Vesicle-mediated Transport Endosome Membrane Metal Ion Transport Negative Regulation Of Protein Secretion Syntaxin-1 Binding Protein Binding Regulation Of Insulin Secretion Inorganic Cation Transmembrane Transport	Potassium Channel Regulator Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Action Potential Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Protein Homooligomerization Protein Complex Oligomerization Regulation Of Membrane Potential Organelle Localization By Membrane Tethering Membrane Docking Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Monoatomic Ion Transport Positive Regulation Of Norepinephrine Secretion FFAT Motif Binding Clustering Of Voltage-gated Potassium Channels Transmembrane Transport COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Protein-containing Complex Assembly Positive Regulation Of Long-term Synaptic Depression Endoplasmic Reticulum Localization Proximal Dendrite Protein-containing Complex Organization Cholinergic Synapse Neuronal Ion Channel Clustering Protein Heterodimerization Activity Host-mediated Activation Of Viral Genome Replication Sphingomyelin Biosynthetic Process Host-mediated Perturbation Of Viral Genome Replication Regulation Of Norepinephrine Secretion Positive Regulation Of Catecholamine Secretion Protein Folding In Endoplasmic Reticulum Host-mediated Suppression Of Viral Genome Replication Ion Channel Inhibitor Activity Regulation Of Motor Neuron Apoptotic Process Regulation Of Long-term Synaptic Depression Potassium Ion Export Across Plasma Membrane Positive Regulation Of Calcium Ion-dependent Exocytosis Outward Rectifier Potassium Channel Activity Protein Localization To Endoplasmic Reticulum Ceramide Transport
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