SVIL and LIMA1

Number of citations of the paper that reports this interaction (PMID 20309963)
11

Data Source:
BioGRID (two hybrid)

		SVIL	LIMA1
Gene Name		supervillin	LIM domain and actin binding 1
Image
Gene Ontology Annotations	Cellular Component	Podosome Nucleus Cytoplasm Plasma Membrane Focal Adhesion Actin Cytoskeleton Midbody Cleavage Furrow Microtubule Minus-end Costamere Invadopodium	Stress Fiber Cytoplasm Plasma Membrane Focal Adhesion Actin Cytoskeleton Cleavage Furrow
	Molecular Function	Protein Binding Actin Filament Binding	Actin Monomer Binding Protein Binding Zinc Ion Binding Actin Filament Binding
	Biological Process	Cytoskeleton Organization Skeletal Muscle Tissue Development Positive Regulation Of Cytokinesis	Negative Regulation Of Actin Filament Depolymerization Ruffle Organization Actin Filament Bundle Assembly
Pathways
Drugs
Diseases
GWAS		Normalized brain volume ( 19010793)
Protein-Protein Interactions		37 interactors: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF14 KIF22 KIFC3 KMT2A KRT18 LIMA1 LMNA LMNB2 LUC7L2 MIF4GD MKL2 MPHOSPH9 NME2 NR3C1 ODF2 P2RX7 PAN3 PCNXL3 PPARG SH3PXD2A STARD9 TGFB1I1 TNFAIP1 TRIP6 UXT YWHAG	5 interactors: APP SVIL UBC YWHAG YWHAQ
Entrez ID		6840	51474
HPRD ID		04992	09755
Ensembl ID		ENSG00000197321	ENSG00000050405
Uniprot IDs		O95425 Q569J5	Q59FE8 Q9UHB6
PDB IDs		2K6M 2K6N	2D8Y
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Cellular Component Organization Mitotic Cell Cycle Process Regulation Of Organelle Organization Mitotic Cell Cycle Cell Cycle Process Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Mitotic Nuclear Division Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Component Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Metabolic Process Multicellular Organismal Development Positive Regulation Of Gene Expression Establishment Of Organelle Localization Apoptotic Process Transcription, DNA-templated Programmed Cell Death Regulation Of Signaling Microtubule-based Process Steroid Hormone Mediated Signaling Pathway Developmental Process Cell Death Death Establishment Of Localization In Cell RNA Biosynthetic Process Metaphase Plate Congression Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Organelle Organization Transcription From RNA Polymerase II Promoter Response To Organic Substance G2/M Transition Of Mitotic Cell Cycle Organelle Localization Heterocycle Metabolic Process Establishment Of Protein Localization Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process	Positive Regulation Of Cell Cycle Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Positive Regulation Of Cell Cycle Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Intracellular Transport Regulation Of Cell Cycle Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Positive Regulation Of Cell Death Establishment Of Localization In Cell G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Notch Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Synaptic Growth At Neuromuscular Junction Membrane Organization Negative Regulation Of Protein Metabolic Process Cellular Localization Regulation Of Cell Cycle Collateral Sprouting In Absence Of Injury Intrinsic Apoptotic Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Intracellular Transport Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Signaling Axon Choice Point Recognition Positive Regulation Of Signal Transduction
Tagcloud ?		10p11 a549 abundant actin bipartite bovine bu cdnas comparatively conservation cooh cytoskeleton deleted filaments gland headpiece hela identity message microvilli nh2 originally s3 salivary supervillin sw480 terminus tightly villin	axis cadherin cascade determinants dissemination dnp73 drives emt eplin establish facilitates igf1r insight invade invasion link mechanistic melanoma metastasis metastasize nonmetastatic p73 reduces slug toward unaffected upregulation widely xenografts
Tagcloud (Difference) ?		10p11 a549 abundant actin bipartite bovine bu cdnas comparatively conservation cooh cytoskeleton deleted filaments gland headpiece hela identity message microvilli nh2 originally s3 salivary supervillin sw480 terminus tightly villin	axis cadherin cascade determinants dissemination dnp73 drives emt eplin establish facilitates igf1r insight invade invasion link mechanistic melanoma metastasis metastasize nonmetastatic p73 reduces slug toward unaffected upregulation widely xenografts
Tagcloud (Intersection) ?