SULT2A1 and STK3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SULT2A1	STK3
Description		sulfotransferase family 2A member 1	serine/threonine kinase 3
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Protein-containing Complex
	Molecular Function	Alcohol Sulfotransferase Activity Protein Binding Sulfotransferase Activity Transferase Activity Bile-salt Sulfotransferase Activity Steroid Sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity Transcription Regulator Activator Activity
	Biological Process	Ethanol Catabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Catabolic Process Bile Acid Catabolic Process Thyroid Hormone Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation	Neural Tube Formation Endocardium Development Protein Phosphorylation Protein Import Into Nucleus Apoptotic Process Signal Transduction JNK Cascade Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Organ Growth Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Protein Tetramerization Centrosome Separation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Protein Localization To Centrosome Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Cytosolic sulfonation of small molecules PPARA activates gene expression Paracetamol ADME	Signaling by Hippo
Drugs		Adenosine 3',5'-diphosphate Aetiocholanolone Mercuric iodide	Fostamatinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Cleft palate ( 30452639) Dehydroepiandrosterone sulphate levels ( 21533175) DHEAS levels ( 34748635) Estradiol levels ( 34255042) Gallstone disease ( 27094239 30504769) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum metabolite levels ( 23093944 33031748) Sex hormone levels ( 26014426) Triglyceride levels ( 32203549) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Urinary metabolite levels in chronic kidney disease ( 31959995)	Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)
Interacting Genes		6 interacting genes: NIF3L1 PRDX4 STAT3 STK3 SULT1B1 TMX1	41 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GABARAP GABARAPL1 GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS2 LRRK2 MAP1LC3B MAP1LC3C MARK2 MBP MOB3B MOB4 MPP1 OGT ORM2 PEX19 PIN1 QARS1 RAF1 RASSF4 SAV1 SLMAP SNIP1 SULT2A1 TFPT TRAF1 TRIM21 TRIM69 ZC3H7A
Entrez ID		6822	6788
HPRD ID		00502	05433
Ensembl ID		ENSG00000105398	ENSG00000104375
Uniprot IDs		A8K015 Q06520	A0A087WZ06 A0A384MR07 Q13188
PDB IDs		1EFH 1J99 1OV4 2QP3 2QP4 3F3Y 4IFB	3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2 8A66
Enriched GO Terms of Interacting Partners?		Uracil Binding Phosphate-containing Compound Metabolic Process Beta-alanine Metabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Regulation Of Developmental Growth Eating Behavior Regulation Of Multicellular Organism Growth Negative Regulation Of Multicellular Organismal Process Energy Homeostasis Response To Metformin Phosphorylation Pyrimidine Nucleoside Catabolic Process Thymine Metabolic Process Thymine Catabolic Process Uracil Catabolic Process Purine Nucleobase Catabolic Process Negative Regulation Of Primary MiRNA Processing Feeding Behavior Transforming Growth Factor Beta Receptor Signaling Pathway Protein Import Into Nucleus Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Developmental Growth I-kappaB Phosphorylation Negative Regulation Of Male Germ Cell Proliferation Import Into Nucleus CMP Catabolic Process DUMP Catabolic Process DCMP Catabolic Process UMP Catabolic Process RNA Sequestering Activity Regulation Of Growth Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Small Molecule Metabolic Process T-helper 17 Type Immune Response Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development GDF15-GFRAL Signaling Pathway Thioredoxin-dependent Peroxiredoxin Activity Regulation Of Male Germ Cell Proliferation Negative Regulation Of Triglyceride Biosynthetic Process Deoxyribonucleoside Catabolic Process Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway	Cellular Response To Nitrogen Starvation Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Regulation Of Hippo Signaling Cytoplasm Mitophagy Autophagosome Cellular Response To Nutrient Levels Autophagosome Assembly Vacuole Organization Cellular Response To Starvation Autophagosome Organization Regulation Of Intracellular Signal Transduction Autophagy Autophagosome Maturation Positive Regulation Of Proteolysis Intracellular Signal Transduction Autophagosome Membrane Response To Starvation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytosol Protein-containing Complex Disassembly Negative Regulation Of Hippo Signaling Hippo Signaling Apoptotic Process Macroautophagy Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Programmed Cell Death Protein Binding Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Organ Growth Signal Transduction Protein-containing Complex Organization Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Nutrient Levels Response To Stress Negative Regulation Of Signaling Negative Regulation Of Cell Communication Pyroptotic Inflammatory Response Regulation Of Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Proteasomal Protein Catabolic Process Protein Serine Kinase Activity
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