SULT2A1 and STK3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SULT2A1	STK3
Gene Name		sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	serine/threonine kinase 3
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Sulfotransferase Activity Bile-salt Sulfotransferase Activity	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine/threonine Kinase Activator Activity Protein Dimerization Activity
	Biological Process	Xenobiotic Metabolic Process Digestion Steroid Metabolic Process Bile Acid Catabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Proliferation Signal Transduction By Phosphorylation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		PPARA activates gene expression Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Fatty acid, triacylglycerol, and ketone body metabolism Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Metabolism of lipids and lipoproteins Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Cytosolic sulfonation of small molecules Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Signaling by Hippo
Drugs		Dehydroepiandrosterone Adenosine-3\'-5\'-Diphosphate Aetiocholanolone Mercury Diiodide
Diseases
GWAS		Dehydroepiandrosterone sulphate levels ( 21533175)
Protein-Protein Interactions		5 interactors: PRDX4 STAT3 STK3 SULT1B1 TMX1	33 interactors: AKT1 CASP3 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KHSRP LATS1 LATS2 LRRK2 MBP MOB4 MPP1 ORM2 PEX19 PHAX QARS RAF1 RASSF1 RASSF2 RASSF4 RASSF5 SAV1 SLMAP SULT2A1 TFPT TRAF1 ZC3H7A
Entrez ID		6822	6788
HPRD ID		00502	05433
Ensembl ID		ENSG00000105398	ENSG00000104375
Uniprot IDs		A8K015 Q06520	B3KYA7 Q13188
PDB IDs		1EFH 1J99 1OV4 2QP3 2QP4 3F3Y 4IFB	4HKD 4L0N 4LG4 4LGD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Male Germ Cell Proliferation Negative Regulation Of Cell Proliferation Cell Redox Homeostasis Regulation Of Male Germ Cell Proliferation Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Phosphate-containing Compound Metabolic Process Negative Regulation Of Locomotion Cellular Modified Amino Acid Metabolic Process Regulation Of Developmental Growth Protein Folding Reproductive Process Negative Regulation Of Glycolytic Process Cellular Response To Stimulus Homeostatic Process Primitive Hemopoiesis Radial Glial Cell Differentiation Regulation Of Cell Proliferation Protein Maturation By Protein Folding Interleukin-6-mediated Signaling Pathway I-kappaB Phosphorylation 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Regulation Of Axon Regeneration Endocardium Development Hepatocyte Apoptotic Process Sulfation Reproductive Structure Development Phosphorylation Intracellular Signal Transduction Reproductive System Development 4-hydroxyproline Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Stimulus Growth Hormone Receptor Signaling Pathway Temperature Homeostasis Flavonoid Metabolic Process Cellular Response To Growth Hormone Stimulus Cellular Response To Interleukin-6 Regulation Of Glycolytic Process Positive Regulation Of Notch Signaling Pathway Thyroid Hormone Metabolic Process Regulation Of Cell Migration Hippo Signaling Eating Behavior Negative Regulation Of Neuron Migration Regulation Of Growth Regulation Of Cell Motility	Hippo Signaling Intracellular Signal Transduction Response To Stimulus Signaling Cell Communication Keratinocyte Differentiation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Metabolic Process Signal Transduction Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Epidermal Cell Differentiation Cell Death Death Negative Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Kinase Activity Nitric Oxide Biosynthetic Process Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Skin Development Negative Regulation Of Kinase Activity Programmed Cell Death Posttranscriptional Regulation Of Gene Expression Regulation Of Protein Kinase Activity Mitotic Cell Cycle Phase Transition Regulation Of Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Epidermis Development Cellular Response To Organic Substance Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Reactive Oxygen Species Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Epithelial Cell Differentiation Negative Regulation Of Oxidative Stress-induced Cell Death
Tagcloud ?		23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 lama3 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm tff top2a	contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1
Tagcloud (Difference) ?		23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 lama3 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm tff top2a	contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1
Tagcloud (Intersection) ?