SULT2A1 and PRDX4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SULT2A1	PRDX4
Description		sulfotransferase family 2A member 1	peroxiredoxin 4
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Alcohol Sulfotransferase Activity Protein Binding Sulfotransferase Activity Transferase Activity Bile-salt Sulfotransferase Activity Steroid Sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Peroxiredoxin Activity Molecular Adaptor Activity Molecular Sequestering Activity Thioredoxin-dependent Peroxiredoxin Activity
	Biological Process	Ethanol Catabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Catabolic Process Bile Acid Catabolic Process Thyroid Hormone Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Extracellular Matrix Organization Hydrogen Peroxide Catabolic Process Cell Redox Homeostasis Protein Maturation Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation
Pathways		Cytosolic sulfonation of small molecules PPARA activates gene expression Paracetamol ADME	Neutrophil degranulation
Drugs		Adenosine 3',5'-diphosphate Aetiocholanolone Mercuric iodide
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Cleft palate ( 30452639) Dehydroepiandrosterone sulphate levels ( 21533175) DHEAS levels ( 34748635) Estradiol levels ( 34255042) Gallstone disease ( 27094239 30504769) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum metabolite levels ( 23093944 33031748) Sex hormone levels ( 26014426) Triglyceride levels ( 32203549) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		6 interacting genes: NIF3L1 PRDX4 STAT3 STK3 SULT1B1 TMX1	27 interacting genes: A1BG ALG12 APOB CDR1 CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 OTUD1 PLG PRDX1 PRDX3 PTBP2 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN
Entrez ID		6822	10549
HPRD ID		00502	05935
Ensembl ID		ENSG00000105398	ENSG00000123131
Uniprot IDs		A8K015 Q06520	Q13162 V9HW63
PDB IDs		1EFH 1J99 1OV4 2QP3 2QP4 3F3Y 4IFB	2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP 8EKW 8EKY
Enriched GO Terms of Interacting Partners?		Uracil Binding Phosphate-containing Compound Metabolic Process Beta-alanine Metabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Regulation Of Developmental Growth Eating Behavior Regulation Of Multicellular Organism Growth Negative Regulation Of Multicellular Organismal Process Energy Homeostasis Response To Metformin Phosphorylation Pyrimidine Nucleoside Catabolic Process Thymine Metabolic Process Thymine Catabolic Process Uracil Catabolic Process Purine Nucleobase Catabolic Process Negative Regulation Of Primary MiRNA Processing Feeding Behavior Transforming Growth Factor Beta Receptor Signaling Pathway Protein Import Into Nucleus Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Developmental Growth I-kappaB Phosphorylation Negative Regulation Of Male Germ Cell Proliferation Import Into Nucleus CMP Catabolic Process DUMP Catabolic Process DCMP Catabolic Process UMP Catabolic Process RNA Sequestering Activity Regulation Of Growth Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Small Molecule Metabolic Process T-helper 17 Type Immune Response Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development GDF15-GFRAL Signaling Pathway Thioredoxin-dependent Peroxiredoxin Activity Regulation Of Male Germ Cell Proliferation Negative Regulation Of Triglyceride Biosynthetic Process Deoxyribonucleoside Catabolic Process Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway	Blood Microparticle Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Thioredoxin Peroxidase Activity Extracellular Space Complement Component C3b Binding Detection Of Molecule Of Bacterial Origin Response To Oxidative Stress Positive Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Regulation Of Hemostasis Regulation Of Blood Coagulation Protein Tag Activity Regulation Of Fibrinolysis Hydrogen Peroxide Catabolic Process Extracellular Exosome Mature Chylomicron Sterol Metabolic Process Cholesterol Metabolic Process Response To External Biotic Stimulus Cholesterol 26-hydroxylase Activity Cholestanetetraol 26-dehydrogenase Activity Bile Acid Metabolic Process Alcohol Catabolic Process Lipopolysaccharide Binding Detection Of Biotic Stimulus Response To Lipopolysaccharide Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Regulation Of Wound Healing Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Symbiont-containing Vacuole Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation NADH-dependent Peroxiredoxin Activity Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity Biological Process Involved In Interaction With Symbiont Response To Molecule Of Bacterial Origin
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