SULT2A1 and PRDX4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SULT2A1	PRDX4
Gene Name		sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	peroxiredoxin 4
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Extracellular Space Nucleus Mitochondrion Smooth Endoplasmic Reticulum Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Sulfotransferase Activity Bile-salt Sulfotransferase Activity	Protein Binding Thioredoxin Peroxidase Activity Protein Homodimerization Activity
	Biological Process	Xenobiotic Metabolic Process Digestion Steroid Metabolic Process Bile Acid Catabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation	I-kappaB Phosphorylation Spermatogenesis Male Gonad Development 4-hydroxyproline Metabolic Process Protein Maturation By Protein Folding Extracellular Matrix Organization Cell Redox Homeostasis Oxidation-reduction Process Reactive Oxygen Species Metabolic Process Negative Regulation Of Male Germ Cell Proliferation
Pathways		PPARA activates gene expression Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Fatty acid, triacylglycerol, and ketone body metabolism Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Metabolism of lipids and lipoproteins Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Cytosolic sulfonation of small molecules Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Dehydroepiandrosterone Adenosine-3\'-5\'-Diphosphate Aetiocholanolone Mercury Diiodide
Diseases
GWAS		Dehydroepiandrosterone sulphate levels ( 21533175)
Protein-Protein Interactions		5 interactors: PRDX4 STAT3 STK3 SULT1B1 TMX1	24 interactors: A1BG ALG12 APOB CFHR1 CFHR3 CLIC1 COX1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 NR4A1 PLG PRDX1 PRDX2 PRDX3 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 VTN
Entrez ID		6822	10549
HPRD ID		00502	05935
Ensembl ID		ENSG00000105398	ENSG00000123131
Uniprot IDs		A8K015 Q06520	Q13162
PDB IDs		1EFH 1J99 1OV4 2QP3 2QP4 3F3Y 4IFB	2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Male Germ Cell Proliferation Negative Regulation Of Cell Proliferation Cell Redox Homeostasis Regulation Of Male Germ Cell Proliferation Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Phosphate-containing Compound Metabolic Process Negative Regulation Of Locomotion Cellular Modified Amino Acid Metabolic Process Regulation Of Developmental Growth Protein Folding Reproductive Process Negative Regulation Of Glycolytic Process Cellular Response To Stimulus Homeostatic Process Primitive Hemopoiesis Radial Glial Cell Differentiation Regulation Of Cell Proliferation Protein Maturation By Protein Folding Interleukin-6-mediated Signaling Pathway I-kappaB Phosphorylation 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Regulation Of Axon Regeneration Endocardium Development Hepatocyte Apoptotic Process Sulfation Reproductive Structure Development Phosphorylation Intracellular Signal Transduction Reproductive System Development 4-hydroxyproline Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Stimulus Growth Hormone Receptor Signaling Pathway Temperature Homeostasis Flavonoid Metabolic Process Cellular Response To Growth Hormone Stimulus Cellular Response To Interleukin-6 Regulation Of Glycolytic Process Positive Regulation Of Notch Signaling Pathway Thyroid Hormone Metabolic Process Regulation Of Cell Migration Hippo Signaling Eating Behavior Negative Regulation Of Neuron Migration Regulation Of Growth Regulation Of Cell Motility	Hydrogen Peroxide Catabolic Process Cellular Response To Reactive Oxygen Species Response To Stress Hydrogen Peroxide Metabolic Process Immune System Process Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Response To Oxidative Stress Response To Inorganic Substance Catabolic Process Reactive Oxygen Species Metabolic Process Defense Response Removal Of Superoxide Radicals Response To Lipopolysaccharide Cellular Response To Superoxide Response To Molecule Of Bacterial Origin Xenobiotic Metabolic Process Negative Regulation Of Proteolysis Cellular Response To Xenobiotic Stimulus Response To Superoxide Response To Oxygen Radical Regulation Of Proteolysis Response To Xenobiotic Stimulus Negative Regulation Of Protein Processing Regulation Of Mitochondrial Membrane Potential Regulation Of Protein Processing Response To Stimulus Bile Acid Metabolic Process Blood Coagulation Hemostasis Superoxide Metabolic Process Platelet Activation Innate Immune Response Cell Migration Positive Regulation Of Wound Healing Response To Lipid Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Thromboxane A2 Signaling Pathway Hsp90 Deacetylation Immune Response Response To Bacterium Carbohydrate Derivative Transport Leukocyte Migration Negative Regulation Of Blood Coagulation Cell Motility Negative Regulation Of Coagulation Steroid Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Wound Healing Regulation Of Body Fluid Levels
Tagcloud ?		23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 lama3 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm tff top2a	1e accomplished antioxidative byproduct disulfide folding glutamine h2o2 hyperoxidation imbalance ins isomerase metabolized negligibly nutrient overwhelm oxidoreductin peroxidase peroxide peroxiredoxin prediabetic proinsulin reoxidizing secretagogue secretagogues secreting stoichiometric takes utilize
Tagcloud (Difference) ?		23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 lama3 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm tff top2a	1e accomplished antioxidative byproduct disulfide folding glutamine h2o2 hyperoxidation imbalance ins isomerase metabolized negligibly nutrient overwhelm oxidoreductin peroxidase peroxide peroxiredoxin prediabetic proinsulin reoxidizing secretagogue secretagogues secreting stoichiometric takes utilize
Tagcloud (Intersection) ?