SULT2A1 and SULT1B1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		SULT2A1	SULT1B1
Description		sulfotransferase family 2A member 1	sulfotransferase family 1B member 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cytosol
	Molecular Function	Alcohol Sulfotransferase Activity Protein Binding Sulfotransferase Activity Transferase Activity Bile-salt Sulfotransferase Activity Steroid Sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding	Aryl Sulfotransferase Activity Protein Binding Sulfotransferase Activity Transferase Activity
	Biological Process	Ethanol Catabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Catabolic Process Bile Acid Catabolic Process Thyroid Hormone Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation	Ethanol Catabolic Process Biogenic Amine Metabolic Process Xenobiotic Metabolic Process Flavonoid Metabolic Process Phenol-containing Compound Metabolic Process Epithelial Cell Differentiation Thyroid Hormone Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation
Pathways		Cytosolic sulfonation of small molecules PPARA activates gene expression Paracetamol ADME	Cytosolic sulfonation of small molecules
Drugs		Adenosine 3',5'-diphosphate Aetiocholanolone Mercuric iodide	Adenosine 3',5'-diphosphate
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Cleft palate ( 30452639) Dehydroepiandrosterone sulphate levels ( 21533175) DHEAS levels ( 34748635) Estradiol levels ( 34255042) Gallstone disease ( 27094239 30504769) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum metabolite levels ( 23093944 33031748) Sex hormone levels ( 26014426) Triglyceride levels ( 32203549) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Urinary metabolite levels in chronic kidney disease ( 31959995)	Nicotine dependence ( 28440896) Uterine fibroids ( 30194396 31649266) White matter hyperintensity volume ( 33293549)
Interacting Genes		6 interacting genes: NIF3L1 PRDX4 STAT3 STK3 SULT1B1 TMX1	4 interacting genes: POT1 SDCBP SULT2A1 SULT2B1
Entrez ID		6822	27284
HPRD ID		00502	07088
Ensembl ID		ENSG00000105398	ENSG00000173597
Uniprot IDs		A8K015 Q06520	O43704
PDB IDs		1EFH 1J99 1OV4 2QP3 2QP4 3F3Y 4IFB	2Z5F 3CKL
Enriched GO Terms of Interacting Partners?		Uracil Binding Phosphate-containing Compound Metabolic Process Beta-alanine Metabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Regulation Of Developmental Growth Eating Behavior Regulation Of Multicellular Organism Growth Negative Regulation Of Multicellular Organismal Process Energy Homeostasis Response To Metformin Phosphorylation Pyrimidine Nucleoside Catabolic Process Thymine Metabolic Process Thymine Catabolic Process Uracil Catabolic Process Purine Nucleobase Catabolic Process Negative Regulation Of Primary MiRNA Processing Feeding Behavior Transforming Growth Factor Beta Receptor Signaling Pathway Protein Import Into Nucleus Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Developmental Growth I-kappaB Phosphorylation Negative Regulation Of Male Germ Cell Proliferation Import Into Nucleus CMP Catabolic Process DUMP Catabolic Process DCMP Catabolic Process UMP Catabolic Process RNA Sequestering Activity Regulation Of Growth Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Small Molecule Metabolic Process T-helper 17 Type Immune Response Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development GDF15-GFRAL Signaling Pathway Thioredoxin-dependent Peroxiredoxin Activity Regulation Of Male Germ Cell Proliferation Negative Regulation Of Triglyceride Biosynthetic Process Deoxyribonucleoside Catabolic Process Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway	Alcohol Sulfotransferase Activity Steroid Sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation Sulfotransferase Activity Interleukin-5 Receptor Complex Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Cholesterol Metabolic Process Sterol Metabolic Process Interleukin-5 Receptor Binding Cholesterol Sulfotransferase Activity Bile Acid Catabolic Process Bile-salt Sulfotransferase Activity Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Telomeric D-loop Binding Telomere Assembly Steroid Metabolic Process Sulfur Compound Metabolic Process Single-stranded Telomeric DNA Binding Regulation Of Extracellular Exosome Assembly Steroid Hormone Binding Shelterin Complex Purine Ribonucleotide Metabolic Process Alcohol Metabolic Process Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process DEAD/H-box RNA Helicase Binding Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Substrate-dependent Cell Migration, Cell Extension 3'-phosphoadenosine 5'-phosphosulfate Binding G-rich Strand Telomeric DNA Binding Purine Nucleotide Metabolic Process Telomeric Loop Disassembly Ethanol Catabolic Process Telomere Capping Ethanol Metabolic Process Nucleotide Metabolic Process Positive Regulation Of Exosomal Secretion Negative Regulation Of Receptor Internalization Regulation Of DNA Strand Elongation Regulation Of Exosomal Secretion
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