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SULT2A1
Gene Name
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Molecular Function
Protein Binding
Sulfotransferase Activity
Bile-salt Sulfotransferase Activity
Biological Process
Xenobiotic Metabolic Process
Digestion
Steroid Metabolic Process
Bile Acid Catabolic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
3'-phosphoadenosine 5'-phosphosulfate Metabolic Process
Sulfation
Pathways
PPARA activates gene expression
Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
Fatty acid, triacylglycerol, and ketone body metabolism
Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
Metabolism of lipids and lipoproteins
Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
Defective UGT1A4 causes hyperbilirubinemia
Metabolic disorders of biological oxidation enzymes
Phase II conjugation
Defective UGT1A1 causes hyperbilirubinemia
Cytosolic sulfonation of small molecules
Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Biological oxidations
Defective GGT1 causes Glutathionuria (GLUTH)
Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Dehydroepiandrosterone
Adenosine-3\'-5\'-Diphosphate
Aetiocholanolone
Mercury Diiodide
Diseases
GWAS
Dehydroepiandrosterone sulphate levels (
21533175
)
Protein-protein Interactions
5 interactors:
PRDX4
STAT3
STK3
SULT1B1
TMX1
Entrez ID
6822
HPRD ID
00502
Ensembl ID
ENSG00000105398
Uniprot IDs
A8K015
Q06520
PDB IDs
1EFH
1J99
1OV4
2QP3
2QP4
3F3Y
4IFB
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Male Germ Cell Proliferation
Negative Regulation Of Cell Proliferation
Cell Redox Homeostasis
Regulation Of Male Germ Cell Proliferation
Negative Regulation Of Cell Migration
Negative Regulation Of Cell Motility
Negative Regulation Of Cellular Component Movement
Phosphate-containing Compound Metabolic Process
Negative Regulation Of Locomotion
Cellular Modified Amino Acid Metabolic Process
Regulation Of Developmental Growth
Protein Folding
Reproductive Process
Negative Regulation Of Glycolytic Process
Cellular Response To Stimulus
Homeostatic Process
Primitive Hemopoiesis
Radial Glial Cell Differentiation
Regulation Of Cell Proliferation
Protein Maturation By Protein Folding
Interleukin-6-mediated Signaling Pathway
I-kappaB Phosphorylation
3'-phosphoadenosine 5'-phosphosulfate Metabolic Process
Regulation Of Axon Regeneration
Endocardium Development
Hepatocyte Apoptotic Process
Sulfation
Reproductive Structure Development
Phosphorylation
Intracellular Signal Transduction
Reproductive System Development
4-hydroxyproline Metabolic Process
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Response To Stimulus
Growth Hormone Receptor Signaling Pathway
Temperature Homeostasis
Flavonoid Metabolic Process
Cellular Response To Growth Hormone Stimulus
Cellular Response To Interleukin-6
Regulation Of Glycolytic Process
Positive Regulation Of Notch Signaling Pathway
Thyroid Hormone Metabolic Process
Regulation Of Cell Migration
Hippo Signaling
Eating Behavior
Negative Regulation Of Neuron Migration
Regulation Of Growth
Regulation Of Cell Motility
Tagcloud
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23h1
aberrations
birc5
ccne2
ctsb
dab2
ddx15
dismal
egr1
etv4
eya4
gata3
gltscr2
hmmr
itgb4
kcnk12
lama3
licam2
loxl2
metastasize
mmp13
mpnst
mpnsts
msh2
pdgfra
rassf2
rhamm
tff
top2a