STYX and TEK

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		STYX	TEK
Description		serine/threonine/tyrosine interacting protein	TEK receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Stress Fiber Extracellular Region Cytoplasm Centrosome Cytoskeleton Actin Filament Plasma Membrane Microvillus Cell-cell Junction Focal Adhesion Basal Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Ciliary Basal Body Receptor Complex Membrane Raft Anchoring Junction
	Molecular Function	Pseudophosphatase Activity Protein Binding F-box Domain Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Signaling Receptor Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Protein Binding Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Regulation Of ERK1 And ERK2 Cascade	Angiogenesis Endothelial Cell Proliferation Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Heart Development Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Hemopoiesis Regulation Of Cell Migration Cell-substrate Adhesion Regulation Of Establishment Or Maintenance Of Cell Polarity Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Positive Regulation Of MAPK Cascade Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Tie Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Definitive Hemopoiesis Heart Trabecula Formation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Glomerulus Vasculature Development Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways			Tie2 Signaling Tie2 Signaling RAF/MAP kinase cascade
Drugs			Ampicillin Vandetanib N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE Regorafenib Ponatinib Tivozanib Fostamatinib Ripretinib
Diseases			Venous malformations, including: Sporadic venous malformation; Cutaneomucosal venous malformation; Glomuvenous malformation
GWAS		Prostate cancer ( 23535732)	Adult asthma ( 27611488) Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Asthma ( 27611488) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Cognitive decline (age-related) ( 28078323) Coronary artery disease ( 29212778) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821)
Interacting Genes		24 interacting genes: AATK CARHSP1 EGFR EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 FBXO7 FBXW7 IGF1R INSR INSRR KDR KIT LMTK2 MAPK1 MUSK PTK7 ROR1 ROR2 TEK	26 interacting genes: ANGPT1 ANGPT2 ANGPT4 ANGPTL1 APP CAV1 DOK2 DOK4 DUSP18 GRB14 GRB2 GRB7 IKBKG ILKAP PIK3R1 PTPN11 PTPRB PTPRR SHC1 SHC4 SOCS1 STAT5A STAT5B STYX TIE1 TNIP2
Entrez ID		6815	7010
HPRD ID		10258	02571
Ensembl ID		ENSG00000198252	ENSG00000120156
Uniprot IDs		Q8WUJ0	Q02763 Q59HG2
PDB IDs		2R0B	1FVR 2GY5 2GY7 2OO8 2OSC 2P4I 2WQB 3BEA 3L8P 4K0V 4X3J 5MYA 5MYB 5UTK 6MWE 7E72
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Kinase Activity Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway ATP Binding Nucleotide Binding Transferase Activity Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Phosphorylation Protein Phosphorylation Growth Factor Binding ERBB2 Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Protein Autophosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Insulin Receptor Activity Signal Transduction Ephrin Receptor Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphate Metabolic Process Peptidyl-tyrosine Phosphorylation Animal Organ Development Insulin Receptor Complex Coreceptor Activity Positive Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Basal Plasma Membrane Positive Regulation Of Cell Migration Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion ERBB Signaling Pathway Regulation Of Phosphorylation Regulation Of Developmental Process Phosphate-containing Compound Metabolic Process Plasma Membrane Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Receptor Tyrosine Kinase Binding Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding Negative Regulation Of Developmental Process Neurotrophin TRKA Receptor Binding Positive Regulation Of Cell Activation ERBB Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Cell Adhesion Regulation Of Body Fluid Levels Positive Regulation Of Multicellular Organismal Process Regulation Of Innate Immune Response Angiogenesis Regulation Of MAPK Cascade Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Natural Killer Cell Mediated Immunity Phosphotyrosine Residue Binding Regulation Of Cell Migration Positive Regulation Of Immune System Process Regulation Of Cell Motility Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis Insulin-like Growth Factor Receptor Binding Phosphoprotein Phosphatase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of ERK1 And ERK2 Cascade Protein Kinase Binding Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Regulation Of Insulin Receptor Signaling Pathway Leukocyte Mediated Cytotoxicity Regulation Of Cellular Response To Insulin Stimulus Regulation Of Signal Transduction Negative Regulation Of Cell Adhesion Response To Growth Factor Regulation Of Immune Response Growth Hormone Receptor Signaling Pathway Development Of Secondary Female Sexual Characteristics
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