STYX and EPHA7

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		STYX	EPHA7
Description		serine/threonine/tyrosine interacting protein	EPH receptor A7
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Plasma Membrane Membrane Dendrite Neuromuscular Junction Neuronal Cell Body Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Specialization Membrane
	Molecular Function	Pseudophosphatase Activity Protein Binding F-box Domain Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity Growth Factor Binding Chemorepellent Activity Ephrin Receptor Binding
	Biological Process	Negative Regulation Of Protein Binding Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Regulation Of ERK1 And ERK2 Cascade	Apoptotic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Brain Development Phosphorylation Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Protein Autophosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Negative Regulation Of Collateral Sprouting Branching Morphogenesis Of A Nerve Regulation Of Peptidyl-tyrosine Phosphorylation Modulation Of Chemical Synaptic Transmission Negative Chemotaxis Neuron Apoptotic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Synapse Assembly Regulation Of ERK1 And ERK2 Cascade Nephric Duct Morphogenesis Regulation Of Postsynapse Organization
Pathways			EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide Fostamatinib
Diseases
GWAS		Prostate cancer ( 23535732)	Adult body size ( 32376654) Adventurousness ( 30643258) Anthropometric traits (multi-trait analysis) ( 30166351) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Chin dimples ( 27182965) Dialysis-related mortality ( 21546767) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gut microbiota relative abundance (Eubacterium belonging to family Erysipelotrichaceae) ( 33208821) Initial pursuit acceleration ( 29064472) Laryngeal squamous cell carcinoma ( 25194280) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Response to hepatitis C treatment ( 22095909) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		24 interacting genes: AATK CARHSP1 EGFR EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 FBXO7 FBXW7 IGF1R INSR INSRR KDR KIT LMTK2 MAPK1 MUSK PTK7 ROR1 ROR2 TEK	12 interacting genes: AFDN DUSP18 DUSP26 EFNA1 EFNA3 EFNA4 EFNA5 GNB1 MAP1LC3A MTMR14 STYX ZNF267
Entrez ID		6815	2045
HPRD ID		10258	03721
Ensembl ID		ENSG00000198252	ENSG00000135333
Uniprot IDs		Q8WUJ0	A0A7P0T9G1 A0A7P0T9L5 A0A7P0T9V9 A0A7P0TA58 Q15375
PDB IDs		2R0B	2REI 3DKO 3H8M 3NRU 7EEC 7EED 7EEF
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Kinase Activity Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway ATP Binding Nucleotide Binding Transferase Activity Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Phosphorylation Protein Phosphorylation Growth Factor Binding ERBB2 Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Protein Autophosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Insulin Receptor Activity Signal Transduction Ephrin Receptor Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphate Metabolic Process Peptidyl-tyrosine Phosphorylation Animal Organ Development Insulin Receptor Complex Coreceptor Activity Positive Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Basal Plasma Membrane Positive Regulation Of Cell Migration Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion ERBB Signaling Pathway Regulation Of Phosphorylation Regulation Of Developmental Process Phosphate-containing Compound Metabolic Process Plasma Membrane Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Side Of Membrane Neuron Projection Guidance Axon Guidance Protein Serine/threonine Phosphatase Activity Transmembrane-ephrin Receptor Activity Protein Tyrosine/serine/threonine Phosphatase Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell-cell Signaling Regulation Of Amyloid Precursor Protein Catabolic Process Signaling Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Enzyme-linked Receptor Protein Signaling Pathway Cell Communication Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Pseudophosphatase Activity Phosphatase Activity Protein Dephosphorylation Regulation Of Cell Adhesion Notochord Formation F-box Domain Binding Protein Tyrosine Phosphatase Activity Plasma Membrane Bounded Cell Projection Organization Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Cellular Response To Oxygen-glucose Deprivation
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