AURKA and INCENP

Number of citations of the paper that reports this interaction (PMID 19357306)
9

Data Source:
BioGRID (enzymatic study)

		AURKA	INCENP
Gene Name		aurora kinase A	inner centromere protein antigens 135/155kDa
Image
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome, Centromeric Region Nucleus Centrosome Spindle Cytosol Spindle Microtubule Microtubule Cytoskeleton Midbody Spindle Pole Centrosome Chromosome Passenger Complex Germinal Vesicle Axon Hillock Pronucleus Perinuclear Region Of Cytoplasm Spindle Midzone Mitotic Spindle Meiotic Spindle	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Lateral Element Central Element Pericentric Heterochromatin Spindle Cytosol Microtubule Chromocenter Midbody Protein Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Serine Kinase Activity	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Mitotic Nuclear Division Mitotic Centrosome Separation Anterior/posterior Axis Specification Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Histone-serine Phosphorylation Negative Regulation Of Apoptotic Process Spindle Stabilization Positive Regulation Of Mitotic Nuclear Division Regulation Of Centrosome Cycle Protein Autophosphorylation Cell Division Centrosome Localization Protein Localization To Centrosome Negative Regulation Of Spindle Checkpoint Positive Regulation Of Oocyte Maturation Neuron Projection Extension	Mitotic Cell Cycle Cytokinesis Chromosome Segregation Mitotic Nuclear Division
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of mitotic cell cycle G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs		Phosphonothreonine Adenosine-5\'-Diphosphate 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE 8-ethyl-3,10,10-trimethyl-4,5,6,8,10,12-hexahydropyrazolo[4\',3\':6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indol-9(1H)-one 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea 1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide 2-(1H-pyrazol-3-yl)-1H-benzimidazole N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE
Diseases
GWAS			Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		54 interactors: APP ARPC1B ARPC2 AURKAIP1 BIRC5 BORA BRCA1 CBX3 CDC20 CDC25B CHFR CKAP5 CSN2 GADD45A GMNN GSK3B HDAC2 HDAC6 HIST3H3 IKBKB INCENP KIF11 KIF2C MAPRE2 MAPRE3 MBD3 MDM2 NDC80 NFKBIA NIN NME1 NUF2 PLK3 PML PPP1CA PPP1CB PPP1CC PRKACA PTTG1 PUM2 RASSF1 SRPK1 SRPK2 SUMO1 TACC1 TACC3 TLK1 TLK2 TP53 TP73 TPX2 UBE2N USP2 VHL	10 interactors: AURKA AURKB AURKC BIRC5 CBX5 CDCA8 EVI5 FLOT1 H2AFZ HIST2H3C
Entrez ID		6790	3619
HPRD ID		04066	05103
Ensembl ID		ENSG00000087586	ENSG00000149503
Uniprot IDs		O14965	Q9NQS7
PDB IDs		1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE 2XNG 2XRU 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6 3K5U 3LAU 3M11 3MYG 3NRM 3O50 3O51 3P9J 3QBN 3R21 3R22 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOK 3UOL 3UP2 3UP7 3VAP 4B0G 4DEA 4DEB 4DED 4DEE 4DHF 4JAI 4JAJ 4JBO 4JBP 4JBQ	2QFA 4AF3
Enriched GO Terms of Interacting Partners?		Cell Cycle Organelle Organization Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Cell Cycle Cell Division Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Radiation Entrainment Of Circadian Clock By Photoperiod Regulation Of Organelle Organization Regulation Of Proteolysis Photoperiodism Entrainment Of Circadian Clock Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Cellular Protein Modification Process Chromosome Segregation Negative Regulation Of Biosynthetic Process Response To Stress Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress Cell Cycle Checkpoint Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Regulation Of Cell Death Response To Light Stimulus Cellular Protein Metabolic Process Circadian Rhythm Response To Growth Factor Regulation Of Apoptotic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Negative Regulation Of Catalytic Activity Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Cellular Component Organization	Mitotic Spindle Organization Cell Division Histone-serine Phosphorylation Spindle Assembly Mitotic Spindle Assembly Mitotic Nuclear Division Positive Regulation Of Cell Division Spindle Organization Histone Phosphorylation Spindle Stabilization Regulation Of Cytokinesis Positive Regulation Of Cell Cycle Process Chromosome Segregation Regulation Of Cell Division Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Positive Regulation Of Cell Cycle Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Spindle Midzone Assembly Attachment Of Spindle Microtubules To Kinetochore Cellular Localization Cytokinesis Peptidyl-serine Phosphorylation Microtubule Cytoskeleton Organization Organelle Assembly Regulation Of Cell Cycle Process Cell Cycle Process Positive Regulation Of Cytokinesis Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Mitotic Nuclear Division Spindle Checkpoint Establishment Of Chromosome Localization Negative Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Negative Regulation Of Protein Binding Microtubule Anchoring Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Spindle Checkpoint Histone Modification Chromosome Organization Organelle Localization Protein Complex Assembly Protein Localization Negative Regulation Of Protein Complex Disassembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Binding
Tagcloud ?		adenosine ags alisertib als ampk antiapoptotic aurora autophagy bioavailable cip1 cytochrome dependently exerts inducing killing kip1 mitochondria monophosphate n78 nci orally phosphatidylinositol proapoptotic proautophagic responds sb202191 threonine waf1 wortmannin	allele aurkb birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Difference) ?		adenosine ags alisertib als ampk antiapoptotic aurora autophagy bioavailable cip1 cytochrome dependently exerts inducing killing kip1 mitochondria monophosphate n78 nci orally phosphatidylinositol proapoptotic proautophagic responds sb202191 threonine waf1 wortmannin	allele aurkb birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Intersection) ?