MAP1LC3C and GMEB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAP1LC3C	GMEB2
Description		microtubule associated protein 1 light chain 3 gamma	glucocorticoid modulatory element binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Autophagosome Assembly Mitophagy Autophagy Response To Stress Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Protein Exit From Endoplasmic Reticulum Aggrephagy Autophagosome Maturation	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II
Pathways		Macroautophagy
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Metabolite levels ( 23823483)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 23535732) Refractive error ( 32231278) Reticulocyte count ( 32888494)
Interacting Genes		41 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG13 ATXN3 BICC1 CALCOCO2 CAPN3 CDC37 CUL3 GMEB2 IRGM KBTBD6 KBTBD7 LAT LMNB1 MEFV MISP NCOR1 NEDD4 NIPBL OPRM1 OPTN PDLIM1 RESF1 RHOXF1 RUFY4 SAMM50 STK3 TAX1BP1 TBC1D25 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 WDFY3 WDR81 ZNF24	20 interacting genes: ATXN1 ATXN1L CBFA2T3 CDC7 CEP19 CREBBP FHL2 GMEB1 LMO2 LMO3 MAP1LC3C MOB1A MXRA8 PIN1 POGZ POU6F2 TRAF3 TTF2 UBE2I ZMYND19
Entrez ID		440738	26205
HPRD ID		14226	16245
Ensembl ID		ENSG00000197769	ENSG00000101216
Uniprot IDs		Q9BXW4	B4DQS0 Q9UKD1
PDB IDs		2NCN 3VVW 3WAM 3WAP 5DPW
Enriched GO Terms of Interacting Partners?		Autophagosome Positive Regulation Of Autophagy Regulation Of Autophagy Autophagy Positive Regulation Of Catabolic Process Regulation Of Macroautophagy Catabolic Process Autophagosome Assembly Positive Regulation Of Macroautophagy Autophagosome Organization Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Protein Polyubiquitination Vacuole Organization Protein K48-linked Ubiquitination Regulation Of Intracellular Signal Transduction Cytosol Organelle Organization Regulation Of Cell Communication Cytoplasmic Vesicle Regulation Of Innate Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Localization To Organelle Macroautophagy Regulation Of Protein Stability Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Signal Transduction Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Innate Immune Response-activating Signaling Pathway Organelle Assembly Ubiquitin-dependent Protein Catabolic Process Protein Localization To Phagocytic Vesicle Regulation Of Autophagosome Maturation Modification-dependent Protein Catabolic Process Cytoplasm Regulation Of Gene Expression Intracellular Protein Localization Regulation Of Macromolecule Metabolic Process Suppression Of Viral Release By Host Autophagosome Membrane Regulation Of Signaling Activation Of Innate Immune Response Protein Monoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Macromolecule Biosynthetic Process Protein-macromolecule Adaptor Activity	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process POZ Domain Binding Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Nucleus Metal Ion Binding Cytoplasm Transcription Factor Binding Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Transcription By RNA Polymerase II BHLH Transcription Factor Binding Postsynaptic Cytosol Recombinational Repair Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Transcription Coregulator Binding Cis-trans Isomerase Activity SUMO Conjugating Enzyme Activity Hsp27 Protein Binding Establishment Of Glial Blood-brain Barrier Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment DNA-binding Transcription Factor Binding Tau Protein Binding Lung Alveolus Development DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Social Behavior Histone H3K27 Acetyltransferase Activity Atrial Cardiac Muscle Cell Development Susceptibility To T Cell Mediated Cytotoxicity Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Double-strand Break Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process DNA Recombination Negative Regulation Of DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation DNA Repair Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
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