MAP1LC3C and WDR81

Number of citations of the paper that reports this interaction (PubMedID 28404643)
46

Data Source:
BioGRID (pull down)

		MAP1LC3C	WDR81
Description		microtubule associated protein 1 light chain 3 gamma	WD repeat domain 81
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule	Autophagosome Membrane Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane
	Molecular Function	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding	Protein Binding Phosphatidylinositol 3-kinase Regulator Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity
	Biological Process	Autophagosome Assembly Mitophagy Autophagy Response To Stress Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Protein Exit From Endoplasmic Reticulum Aggrephagy Autophagosome Maturation	Ubiquitin-dependent Protein Catabolic Process Mitochondrion Organization Aggrephagy Early Endosome To Late Endosome Transport Protein Stabilization
Pathways		Macroautophagy	CDC42 GTPase cycle
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Metabolite levels ( 23823483)	Apolipoprotein B levels ( 32203549) Calcium levels ( 20705733 24068962) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum albumin levels ( 23022100) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 32203549) Urinary albumin-to-creatinine ratio ( 31630189) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		41 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG13 ATXN3 BICC1 CALCOCO2 CAPN3 CDC37 CUL3 GMEB2 IRGM KBTBD6 KBTBD7 LAT LMNB1 MEFV MISP NCOR1 NEDD4 NIPBL OPRM1 OPTN PDLIM1 RESF1 RHOXF1 RUFY4 SAMM50 STK3 TAX1BP1 TBC1D25 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 WDFY3 WDR81 ZNF24	2 interacting genes: MAP1LC3C SQSTM1
Entrez ID		440738	124997
HPRD ID		14226	08748
Ensembl ID		ENSG00000197769	ENSG00000167716
Uniprot IDs		Q9BXW4	Q24JR4 Q562E7
PDB IDs		2NCN 3VVW 3WAM 3WAP 5DPW
Enriched GO Terms of Interacting Partners?		Autophagosome Positive Regulation Of Autophagy Regulation Of Autophagy Autophagy Positive Regulation Of Catabolic Process Regulation Of Macroautophagy Catabolic Process Autophagosome Assembly Positive Regulation Of Macroautophagy Autophagosome Organization Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Protein Polyubiquitination Vacuole Organization Protein K48-linked Ubiquitination Regulation Of Intracellular Signal Transduction Cytosol Organelle Organization Regulation Of Cell Communication Cytoplasmic Vesicle Regulation Of Innate Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Localization To Organelle Macroautophagy Regulation Of Protein Stability Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Signal Transduction Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Innate Immune Response-activating Signaling Pathway Organelle Assembly Ubiquitin-dependent Protein Catabolic Process Protein Localization To Phagocytic Vesicle Regulation Of Autophagosome Maturation Modification-dependent Protein Catabolic Process Cytoplasm Regulation Of Gene Expression Intracellular Protein Localization Regulation Of Macromolecule Metabolic Process Suppression Of Viral Release By Host Autophagosome Membrane Regulation Of Signaling Activation Of Innate Immune Response Protein Monoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Macromolecule Biosynthetic Process Protein-macromolecule Adaptor Activity	Aggrephagy Mitophagy Autophagosome Autophagy Of Mitochondrion Macroautophagy Autophagy Brown Fat Cell Proliferation Amphisome Ubiquitin Protein Ligase Binding Lewy Body Response To Mitochondrial Depolarisation Fat Cell Proliferation Protein Localization To Perinuclear Region Of Cytoplasm Intracellular Membraneless Organelle Intracellular Protein Transport Ubiquitin-modified Protein Reader Activity Cellular Response To Nitrogen Starvation Regulation Of Protein Complex Stability Negative Regulation Of Ferroptosis Protein Targeting To Vacuole Involved In Autophagy Autolysosome Molecular Sequestering Activity Regulation Of Ferroptosis Pexophagy Organelle Assembly Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphatidylethanolamine Binding Inclusion Body Cytoplasmic Vesicle Positive Regulation Of Long-term Synaptic Potentiation K63-linked Polyubiquitin Modification-dependent Protein Binding Phagophore Assembly Site Ionotropic Glutamate Receptor Binding Protein Exit From Endoplasmic Reticulum Regulation Of Toll-like Receptor 4 Signaling Pathway Protein Transport Aggresome Temperature Homeostasis Regulation Of Long-term Synaptic Potentiation Cell Surface Toll-like Receptor Signaling Pathway SH2 Domain Binding Establishment Of Protein Localization Protein Kinase C Binding Sperm Midpiece Regulation Of Ras Protein Signal Transduction Toll-like Receptor 4 Signaling Pathway Molecular Condensate Scaffold Activity Intracellular Transport Protein Sequestering Activity Organelle Membrane
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