MAP1LC3C and WDFY3

Number of citations of the paper that reports this interaction (PubMedID 24668264)
19

Data Source:
BioGRID (pull down)

		MAP1LC3C	WDFY3
Description		microtubule associated protein 1 light chain 3 gamma	WD repeat and FYVE domain containing 3
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GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule	Autophagosome Membrane Nucleus Nuclear Envelope Nucleoplasm Nucleolus Cytoplasm Autophagosome Cytosol Plasma Membrane Membrane Inclusion Body PML Body Axon Nuclear Membrane Atg12-Atg5-Atg16 Complex Cell Projection Perikaryon
	Molecular Function	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding	Protein Binding 1-phosphatidylinositol Binding Zinc Ion Binding Lipid Binding Metal Ion Binding
	Biological Process	Autophagosome Assembly Mitophagy Autophagy Response To Stress Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Protein Exit From Endoplasmic Reticulum Aggrephagy Autophagosome Maturation	Autophagy Macroautophagy Aggrephagy
Pathways		Macroautophagy
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Metabolite levels ( 23823483)	Cerebral amyloid deposition (PET imaging) ( 26252872) Monocyte percentage of white cells ( 32888494) Oropharynx cancer ( 27749845)
Interacting Genes		41 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG13 ATXN3 BICC1 CALCOCO2 CAPN3 CDC37 CUL3 GMEB2 IRGM KBTBD6 KBTBD7 LAT LMNB1 MEFV MISP NCOR1 NEDD4 NIPBL OPRM1 OPTN PDLIM1 RESF1 RHOXF1 RUFY4 SAMM50 STK3 TAX1BP1 TBC1D25 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 WDFY3 WDR81 ZNF24	16 interacting genes: ATG5 BTG3 CEP76 GABARAPL1 GABARAPL2 GRB2 MAP1LC3C MDFI PRMT1 PRMT6 RABGAP1L STAT3 SUV39H1 TNS2 TRIM39 ZBTB44
Entrez ID		440738	23001
HPRD ID		14226	10304
Ensembl ID		ENSG00000197769	ENSG00000163625
Uniprot IDs		Q9BXW4	Q8IZQ1
PDB IDs		2NCN 3VVW 3WAM 3WAP 5DPW	3WIM 6W9N
Enriched GO Terms of Interacting Partners?		Autophagosome Positive Regulation Of Autophagy Regulation Of Autophagy Autophagy Positive Regulation Of Catabolic Process Regulation Of Macroautophagy Catabolic Process Autophagosome Assembly Positive Regulation Of Macroautophagy Autophagosome Organization Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Protein Polyubiquitination Vacuole Organization Protein K48-linked Ubiquitination Regulation Of Intracellular Signal Transduction Cytosol Organelle Organization Regulation Of Cell Communication Cytoplasmic Vesicle Regulation Of Innate Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Localization To Organelle Macroautophagy Regulation Of Protein Stability Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Signal Transduction Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Innate Immune Response-activating Signaling Pathway Organelle Assembly Ubiquitin-dependent Protein Catabolic Process Protein Localization To Phagocytic Vesicle Regulation Of Autophagosome Maturation Modification-dependent Protein Catabolic Process Cytoplasm Regulation Of Gene Expression Intracellular Protein Localization Regulation Of Macromolecule Metabolic Process Suppression Of Viral Release By Host Autophagosome Membrane Regulation Of Signaling Activation Of Innate Immune Response Protein Monoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Macromolecule Biosynthetic Process Protein-macromolecule Adaptor Activity	Cellular Response To Nitrogen Starvation Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Mitophagy Phosphatidylethanolamine Binding Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Cellular Response To Stress Response To Nutrient Levels Histone Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Macroautophagy Autophagosome Maturation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Vacuole Organization Autophagosome Membrane Protein-arginine N-methyltransferase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Aggrephagy Response To Stress GABA Receptor Binding Autophagy Negative Regulation Of Protein Metabolic Process Phospholipid Binding Histone H3 Methyltransferase Activity Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Proteolysis Protein-containing Complex Disassembly Negative Regulation Of Catabolic Process Organelle Assembly Methyltransferase Activity Positive Regulation Of Erythrocyte Differentiation Regulation Of Megakaryocyte Differentiation DNA Damage Response Beta-tubulin Binding Protein Sequestering Activity Methylation Cytoplasmic Vesicle Guanyl-nucleotide Exchange Factor Adaptor Activity GATOR1 Complex Binding Histone H2AR3 Methyltransferase Activity Regulation Of Erythrocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Myeloid Cell Differentiation Cytoplasm Negative Regulation Of Proteasomal Protein Catabolic Process
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