MAOB

Gene Name		monoamine oxidase B
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Mitochondrial Inner Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Primary Amine Oxidase Activity Electron Carrier Activity Protein Homodimerization Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Xenobiotic Metabolic Process Response To Toxic Substance Response To Aluminum Ion Response To Selenium Ion Negative Regulation Of Serotonin Secretion Substantia Nigra Development Response To Lipopolysaccharide Dopamine Catabolic Process Response To Drug Small Molecule Metabolic Process Response To Ethanol Positive Regulation Of Dopamine Metabolic Process Hydrogen Peroxide Biosynthetic Process Response To Corticosterone Oxidation-reduction Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Biological oxidations Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Amine Oxidase reactions Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs		Phentermine Tranylcypromine Phenelzine Zonisamide Selegiline Isocarboxazid Ephedra Rasagiline MMDA 4-Methoxyamphetamine Methamphetamine Pargyline Isatin N-Methyl-N-Propargyl-1(R)-Aminoindan Farnesol N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate [(1e)-4-Phenylbut-1-Enyl]Benzene Flavin-Adenine Dinucleotide N-Propargyl-1(S)-Aminoindan Lauryl Dimethylamine-N-Oxide 5-Hydroxy-N-Propargyl-1(R)-Aminoindan N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE Nialamide Nomifensine Zimelidine 7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE N-(2-AMINOETHYL)-P-CHLOROBENZAMIDE (1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINE 4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN (S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE]
Diseases
GWAS
Protein-protein Interactions		2 interactors: NFYB SRPK1
Entrez ID		4129
HPRD ID		02401
Ensembl ID		ENSG00000069535
Uniprot IDs		B7Z242 B7Z5H3 P27338
PDB IDs		1GOS 1H8R 1OJ9 1OJA 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C70 2C72 2C73 2C75 2C76 2V5Z 2V60 2V61 2VRL 2VRM 2VZ2 2XCG 2XFN 2XFO 2XFP 2XFQ 2XFU 3PO7 3ZYX 4A79 4A7A
Enriched GO Terms of Interacting Partners?
Tagcloud ?		black c57 competitive concentrated depleting dopamine dopaminergic exerts inactivates intraneuronally irreversible irreversibly keeping kinetics label mazindol moiety mptp neurotoxin pargyline phenyl pretreatment protected pyridinium radioligand striatal terminals tetrahydropyridine uptake