EDN2 and CMA1

Number of citations of the paper that reports this interaction (PubMedID 9675146)
0

Data Source:
HPRD (in vitro)

		EDN2	CMA1
Description		endothelin 2	chymase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Cytosol Secretory Granule Extracellular Matrix Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Hormone Activity Endothelin B Receptor Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Peptide Binding
	Biological Process	Angiogenesis Temperature Homeostasis Vasculature Development Positive Regulation Of Leukocyte Chemotaxis Hormonal Regulation Of The Force Of Heart Contraction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Systemic Arterial Blood Pressure By Endothelin Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Tip Growth Positive Regulation Of Heart Rate Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Cytokine-mediated Signaling Pathway Regulation Of Vasoconstriction Neutrophil Chemotaxis Neuron Projection Development Positive Regulation Of Prostaglandin Biosynthetic Process Macrophage Activation Vasoconstriction Endothelial Cell Migration Positive Regulation Of Smooth Muscle Contraction Macrophage Chemotaxis Lung Alveolus Development Axon Extension Positive Regulation Of Calcium-mediated Signaling Endothelin Receptor Signaling Pathway Energy Homeostasis Blood Vessel Diameter Maintenance	Angiotensin Maturation Proteolysis Peptide Metabolic Process Protein Processing Extracellular Matrix Disassembly Protein Catabolic Process Midbrain Development Basement Membrane Disassembly Positive Regulation Of Angiogenesis Regulation Of Inflammatory Response Protein Maturation Cellular Response To Glucose Stimulus Cytokine Precursor Processing
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Signaling by SCF-KIT Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins
Drugs			Benzylsulfonic acid 2-(N-morpholino)ethanesulfonic acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID
Diseases
GWAS		Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Phenylephrine infusion rate during anesthesia ( 31455332) PR interval ( 32439900) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		3 interacting genes: CMA1 KEL MME	10 interacting genes: AGT EDN1 EDN2 EDN3 FYN IL1B KITLG MMP1 PFN1 SERPINA3
Entrez ID		1907	1215
HPRD ID		07173	00346
Ensembl ID		ENSG00000127129	ENSG00000092009
Uniprot IDs		P20800	P23946 Q4FEB3
PDB IDs			1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69 4KP0 5YJM 5YJP 7H60 7H61 7H62 7H63 7H64 7H65 7H66 7H67 7H68 7H69 7H6A 7H6B 7H6C 7H6D 7H6E 7H6F 7H6I 9GBH 9GC1 9GC9 9GCC 9GCD
Enriched GO Terms of Interacting Partners?		Angiotensin Maturation Protein Processing Peptide Binding Protein Maturation Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptide Metabolic Process Peptidase Activity Endopeptidase Activity Metalloendopeptidase Activity Neuropeptide Processing Metallopeptidase Activity Oligopeptidase Activity Creatinine Metabolic Process Hormone Metabolic Process Basement Membrane Disassembly Substance P Catabolic Process Exopeptidase Activity Cytokine Precursor Processing Regulation Of Axon Diameter Neuropeptide Catabolic Process Proteolysis Intracellular Magnesium Ion Homeostasis Signal Recognition Particle Bradykinin Catabolic Process Amyloid-beta Clearance By Cellular Catabolic Process Signal Recognition Particle Binding Signal Recognition Particle, Endoplasmic Reticulum Targeting 7S RNA Binding TPR Domain Binding Cellular Response To UV-A SRP-dependent Cotranslational Protein Targeting To Membrane Regulation Of Cell Projection Size Magnesium Ion Homeostasis Cardiolipin Binding Hydrolase Activity Response To UV-A Cellular Response To UV-B Hormone Catabolic Process Replicative Senescence Cotranslational Protein Targeting To Membrane Peptide Catabolic Process Neuron Projection Terminus Intracellular Chemical Homeostasis Regulation Of Hormone Levels Negative Regulation Of Potassium Ion Transmembrane Transport Response To UV-B Positive Regulation Of Long-term Synaptic Potentiation Amyloid-beta Metabolic Process Metallocarboxypeptidase Activity	Endothelin B Receptor Binding Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Vein Smooth Muscle Contraction Leukocyte Migration Vasoconstriction Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Locomotion Myeloid Leukocyte Migration Regulation Of Systemic Arterial Blood Pressure Regulation Of Locomotion Positive Regulation Of Prostaglandin Biosynthetic Process Artery Smooth Muscle Contraction Neutrophil Chemotaxis Tonic Smooth Muscle Contraction Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Regulation Of Prostaglandin Biosynthetic Process Regulation Of Vasoconstriction Neutrophil Migration Granulocyte Chemotaxis Vascular Associated Smooth Muscle Contraction Granulocyte Migration Positive Regulation Of Fatty Acid Biosynthetic Process Hormone Activity Positive Regulation Of Heart Rate Positive Regulation Of Cellular Component Organization Circulatory System Process Regulation Of Lipid Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Lipid Metabolic Process Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Heart Contraction Positive Regulation Of Fatty Acid Metabolic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Positive Regulation Of Small Molecule Metabolic Process Extracellular Region Regulation Of Blood Pressure Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Axon Extension Positive Regulation Of Muscle Contraction System Process Extracellular Space Cell Migration
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