EDN2

Description		endothelin 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Hormone Activity Endothelin B Receptor Binding
	Biological Process	Angiogenesis Temperature Homeostasis Vasculature Development Positive Regulation Of Leukocyte Chemotaxis Hormonal Regulation Of The Force Of Heart Contraction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Systemic Arterial Blood Pressure By Endothelin Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Tip Growth Positive Regulation Of Heart Rate Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Cytokine-mediated Signaling Pathway Regulation Of Vasoconstriction Neutrophil Chemotaxis Neuron Projection Development Positive Regulation Of Prostaglandin Biosynthetic Process Macrophage Activation Vasoconstriction Endothelial Cell Migration Positive Regulation Of Smooth Muscle Contraction Macrophage Chemotaxis Lung Alveolus Development Axon Extension Positive Regulation Of Calcium-mediated Signaling Endothelin Receptor Signaling Pathway Energy Homeostasis Blood Vessel Diameter Maintenance
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Phenylephrine infusion rate during anesthesia ( 31455332) PR interval ( 32439900) Squamous cell lung carcinoma ( 28604730)
Novel Interacting Genes		1 novel interacting genes: SRP72
Interacting Genes		3 interacting genes: CMA1 KEL MME
Entrez ID		1907
HPRD ID		07173
Ensembl ID		ENSG00000127129
Uniprot IDs		P20800
PDB IDs
Enriched GO Terms of Interacting Partners?		Angiotensin Maturation Protein Processing Peptide Binding Protein Maturation Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptide Metabolic Process Peptidase Activity Endopeptidase Activity Metalloendopeptidase Activity Neuropeptide Processing Metallopeptidase Activity Oligopeptidase Activity Creatinine Metabolic Process Hormone Metabolic Process Basement Membrane Disassembly Substance P Catabolic Process Exopeptidase Activity Cytokine Precursor Processing Regulation Of Axon Diameter Neuropeptide Catabolic Process Proteolysis Intracellular Magnesium Ion Homeostasis Signal Recognition Particle Bradykinin Catabolic Process Amyloid-beta Clearance By Cellular Catabolic Process Signal Recognition Particle Binding Signal Recognition Particle, Endoplasmic Reticulum Targeting 7S RNA Binding TPR Domain Binding Cellular Response To UV-A SRP-dependent Cotranslational Protein Targeting To Membrane Regulation Of Cell Projection Size Magnesium Ion Homeostasis Cardiolipin Binding Hydrolase Activity Response To UV-A Cellular Response To UV-B Hormone Catabolic Process Replicative Senescence Cotranslational Protein Targeting To Membrane Peptide Catabolic Process Neuron Projection Terminus Intracellular Chemical Homeostasis Regulation Of Hormone Levels Negative Regulation Of Potassium Ion Transmembrane Transport Response To UV-B Positive Regulation Of Long-term Synaptic Potentiation Amyloid-beta Metabolic Process Metallocarboxypeptidase Activity
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