EDN2 and MME

Number of citations of the paper that reports this interaction (PubMedID 2201681)
0

Data Source:
HPRD (in vitro)

		EDN2	MME
Description		endothelin 2	membrane metalloendopeptidase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Nucleoplasm Cytoplasm Early Endosome Trans-Golgi Network Centrosome Cytosol Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Cell Surface Membrane Axon Dendrite Secretory Granule Membrane Cytoplasmic Vesicle Ciliary Basal Body Neuronal Cell Body Neuron Projection Terminus Membrane Raft Synapse Extracellular Exosome Presynapse
	Molecular Function	Hormone Activity Endothelin B Receptor Binding	Phosphatidylserine Binding Endopeptidase Activity Metallocarboxypeptidase Activity Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Exopeptidase Activity Zinc Ion Binding Hydrolase Activity Peptide Binding Protein Homodimerization Activity Metal Ion Binding Oligopeptidase Activity Cardiolipin Binding
	Biological Process	Angiogenesis Temperature Homeostasis Vasculature Development Positive Regulation Of Leukocyte Chemotaxis Hormonal Regulation Of The Force Of Heart Contraction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Systemic Arterial Blood Pressure By Endothelin Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Tip Growth Positive Regulation Of Heart Rate Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Cytokine-mediated Signaling Pathway Regulation Of Vasoconstriction Neutrophil Chemotaxis Neuron Projection Development Positive Regulation Of Prostaglandin Biosynthetic Process Macrophage Activation Vasoconstriction Endothelial Cell Migration Positive Regulation Of Smooth Muscle Contraction Macrophage Chemotaxis Lung Alveolus Development Axon Extension Positive Regulation Of Calcium-mediated Signaling Endothelin Receptor Signaling Pathway Energy Homeostasis Blood Vessel Diameter Maintenance	Kidney Development Placenta Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Learning Or Memory Substance P Catabolic Process Bradykinin Catabolic Process Protein Processing Sensory Perception Of Pain Protein Catabolic Process Lung Development Hormone Catabolic Process Response To Estrogen Creatinine Metabolic Process Amyloid-beta Metabolic Process Positive Regulation Of Neurogenesis Neuropeptide Processing Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Long-term Synaptic Potentiation
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Metabolism of Angiotensinogen to Angiotensins Physiological factors Neutrophil degranulation Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs			Candoxatril Omapatrilat N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala Daglutril 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan Sacubitril Candoxatrilat
Diseases
GWAS		Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Phenylephrine infusion rate during anesthesia ( 31455332) PR interval ( 32439900) Squamous cell lung carcinoma ( 28604730)	Diastolic blood pressure ( 27841878) Primary sclerosing cholangitis ( 27992413) Systolic blood pressure ( 27841878) Triglyceride levels in HIV infection ( 33109212) Vaginal microbiome composition (Shannon diversity index) ( 32723796)
Interacting Genes		3 interacting genes: CMA1 KEL MME	20 interacting genes: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 EZR GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 PTEN SHC1 SNCA TMEM132D VIP
Entrez ID		1907	4311
HPRD ID		07173	00392
Ensembl ID		ENSG00000127129	ENSG00000196549
Uniprot IDs		P20800	P08473 Q3KQS6
PDB IDs			1DMT 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 4CTH 5JMY 6GID 6SH1 6SH2 6SUK 6SVY 6THP 6XVP
Enriched GO Terms of Interacting Partners?		Angiotensin Maturation Protein Processing Peptide Binding Protein Maturation Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptide Metabolic Process Peptidase Activity Endopeptidase Activity Metalloendopeptidase Activity Neuropeptide Processing Metallopeptidase Activity Oligopeptidase Activity Creatinine Metabolic Process Hormone Metabolic Process Basement Membrane Disassembly Substance P Catabolic Process Exopeptidase Activity Cytokine Precursor Processing Regulation Of Axon Diameter Neuropeptide Catabolic Process Proteolysis Intracellular Magnesium Ion Homeostasis Signal Recognition Particle Bradykinin Catabolic Process Amyloid-beta Clearance By Cellular Catabolic Process Signal Recognition Particle Binding Signal Recognition Particle, Endoplasmic Reticulum Targeting 7S RNA Binding TPR Domain Binding Cellular Response To UV-A SRP-dependent Cotranslational Protein Targeting To Membrane Regulation Of Cell Projection Size Magnesium Ion Homeostasis Cardiolipin Binding Hydrolase Activity Response To UV-A Cellular Response To UV-B Hormone Catabolic Process Replicative Senescence Cotranslational Protein Targeting To Membrane Peptide Catabolic Process Neuron Projection Terminus Intracellular Chemical Homeostasis Regulation Of Hormone Levels Negative Regulation Of Potassium Ion Transmembrane Transport Response To UV-B Positive Regulation Of Long-term Synaptic Potentiation Amyloid-beta Metabolic Process Metallocarboxypeptidase Activity	Hormone Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Blood Vessel Diameter Maintenance Regulation Of Tube Size Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Regulation Of Biological Quality Positive Regulation Of Heart Contraction Intracellular Signal Transduction Extracellular Space Negative Regulation Of Protein Metabolic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of Protein Metabolic Process Signaling Receptor Binding Regulation Of Multicellular Organismal Process Regulation Of MAPK Cascade Vascular Process In Circulatory System Extracellular Region Positive Regulation Of Small Molecule Metabolic Process Regulation Of Vasoconstriction Signal Release Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Regulation Of Blood Pressure Circulatory System Process Negative Regulation Of MAPK Cascade Regulation Of Locomotion Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Cell-cell Signaling Regulation Of Transport Regulation Of Growth Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hormone Secretion Protein Kinase CK2 Complex
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