EDN2 and KEL

Number of citations of the paper that reports this interaction (PubMedID 10438732)
0

Data Source:
HPRD (in vivo)

		EDN2	KEL
Description		endothelin 2	Kell metallo-endopeptidase (Kell blood group)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane
	Molecular Function	Hormone Activity Endothelin B Receptor Binding	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Angiogenesis Temperature Homeostasis Vasculature Development Positive Regulation Of Leukocyte Chemotaxis Hormonal Regulation Of The Force Of Heart Contraction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Systemic Arterial Blood Pressure By Endothelin Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Tip Growth Positive Regulation Of Heart Rate Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Cytokine-mediated Signaling Pathway Regulation Of Vasoconstriction Neutrophil Chemotaxis Neuron Projection Development Positive Regulation Of Prostaglandin Biosynthetic Process Macrophage Activation Vasoconstriction Endothelial Cell Migration Positive Regulation Of Smooth Muscle Contraction Macrophage Chemotaxis Lung Alveolus Development Axon Extension Positive Regulation Of Calcium-mediated Signaling Endothelin Receptor Signaling Pathway Energy Homeostasis Blood Vessel Diameter Maintenance	Proteolysis Intracellular Calcium Ion Homeostasis Regulation Of Cell Size Intracellular Magnesium Ion Homeostasis Protein Processing Regulation Of Axon Diameter Vasoconstriction Myelination Skeletal Muscle Fiber Development Establishment Of Localization In Cell Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Peptide ligand-binding receptors
Drugs			Phosphoramidon
Diseases
GWAS		Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Phenylephrine infusion rate during anesthesia ( 31455332) PR interval ( 32439900) Squamous cell lung carcinoma ( 28604730)	Alcoholic chronic pancreatitis ( 28754779) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494)
Interacting Genes		3 interacting genes: CMA1 KEL MME	12 interacting genes: ADIPOQ C3orf52 C5 CLDN19 EDN1 EDN2 EDN3 EWSR1 PM20D2 TUBA1A UBC XK
Entrez ID		1907	3792
HPRD ID		07173	00194
Ensembl ID		ENSG00000127129	ENSG00000197993
Uniprot IDs		P20800	A0A077QP03 P23276
PDB IDs
Enriched GO Terms of Interacting Partners?		Angiotensin Maturation Protein Processing Peptide Binding Protein Maturation Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptide Metabolic Process Peptidase Activity Endopeptidase Activity Metalloendopeptidase Activity Neuropeptide Processing Metallopeptidase Activity Oligopeptidase Activity Creatinine Metabolic Process Hormone Metabolic Process Basement Membrane Disassembly Substance P Catabolic Process Exopeptidase Activity Cytokine Precursor Processing Regulation Of Axon Diameter Neuropeptide Catabolic Process Proteolysis Intracellular Magnesium Ion Homeostasis Signal Recognition Particle Bradykinin Catabolic Process Amyloid-beta Clearance By Cellular Catabolic Process Signal Recognition Particle Binding Signal Recognition Particle, Endoplasmic Reticulum Targeting 7S RNA Binding TPR Domain Binding Cellular Response To UV-A SRP-dependent Cotranslational Protein Targeting To Membrane Regulation Of Cell Projection Size Magnesium Ion Homeostasis Cardiolipin Binding Hydrolase Activity Response To UV-A Cellular Response To UV-B Hormone Catabolic Process Replicative Senescence Cotranslational Protein Targeting To Membrane Peptide Catabolic Process Neuron Projection Terminus Intracellular Chemical Homeostasis Regulation Of Hormone Levels Negative Regulation Of Potassium Ion Transmembrane Transport Response To UV-B Positive Regulation Of Long-term Synaptic Potentiation Amyloid-beta Metabolic Process Metallocarboxypeptidase Activity	Endothelin B Receptor Binding Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Vascular Associated Smooth Muscle Contraction Positive Regulation Of Heart Rate Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Hormone Activity Positive Regulation Of Smooth Muscle Contraction Vasoconstriction Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Heart Contraction Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure Axon Extension Regulation Of Blood Pressure Positive Regulation Of Muscle Contraction Intracellular Magnesium Ion Homeostasis Neutrophil Chemotaxis Smooth Muscle Contraction Intracellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Cell Chemotaxis Regulation Of Chemotaxis Regulation Of Vasoconstriction Neutrophil Migration Positive Regulation Of Prostaglandin Biosynthetic Process Calcium Ion Homeostasis Regulation Of Leukocyte Migration Leukocyte Migration Granulocyte Chemotaxis Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Neuron Projection Extension Endothelin Receptor Signaling Pathway Regulation Of Prostaglandin Biosynthetic Process Magnesium Ion Homeostasis Granulocyte Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Fatty Acid Metabolic Process Regulation Of Cell Migration Regulation Of Heart Rate Regulation Of Cell Motility Regulation Of Locomotion Chemotaxis Developmental Cell Growth Response To Tumor Necrosis Factor Regulation Of Ketone Metabolic Process Myeloid Leukocyte Migration Locomotion
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