ABLIM2 and ATP6V0A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ABLIM2	ATP6V0A1
Description		actin binding LIM protein family member 2	ATPase H+ transporting V0 subunit a1
Image
GO Annotations	Cellular Component	Cytoplasm Actin Cytoskeleton	Vacuolar Proton-transporting V-type ATPase, V0 Domain Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Membrane Vacuolar Proton-transporting V-type ATPase Complex Nuclear Speck Clathrin-coated Vesicle Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V0 Domain Melanosome Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Actin Binding Protein Binding Metal Ion Binding Actin Filament Binding	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Cytoskeleton Organization Lamellipodium Assembly	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Endosomal Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		DCC mediated attractive signaling	ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport
Drugs			Tiludronic acid
Diseases
GWAS		Cognitive function ( 28808816) Diffusing capacity of carbon monoxide ( 30694715) Early onset periodontitis x smoking status interaction ( 31537151) Irritable bowel syndrome ( 29626450) Post bronchodilator FEV1 in COPD ( 26634245) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Triacylglyceride levels ( 31551469)	Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: ABRA AHNAK2 ATP6V0A1 MLIP SREBF2 TTN	8 interacting genes: ABLIM2 CLIC1 CYTH2 HRH1 SEH1L SNX4 TTC3 ZNF267
Entrez ID		84448	535
HPRD ID		10623	01886
Ensembl ID		ENSG00000163995	ENSG00000033627
Uniprot IDs		A0A140VK02 F5GYR0 Q6H8Q1	A0A994J3Z0 A0A994J3Z4 A0A994J3Z9 B7Z2A9 B7Z641 K7EN36 K7ENA1 K7ERA6 Q53ET5 Q53X12 Q93050
PDB IDs		1V6G 1WIG 2L3X	6WLW 6WM2 6WM3 6WM4 7U4T
Enriched GO Terms of Interacting Partners?		Endosomal Lumen Acidification Proton-transporting V-type ATPase, V0 Domain Cytoplasm Regulation Of Macroautophagy Regulation Of Metabolic Process Regulation Of Autophagy Synaptic Vesicle Lumen Acidification Proton-transporting V-type ATPase Complex Vacuolar Proton-transporting V-type ATPase, V0 Domain Vacuolar Proton-transporting V-type ATPase Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Response To Sterol Depletion Regulation Of Amyloid-beta Clearance Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Negative Regulation Of Cholesterol Efflux Regulation Of Gene Expression Positive Regulation Of Lipid Storage Cellular Response To Laminar Fluid Shear Stress Cellular Response To Sterol Depletion SREBP-SCAP-Insig Complex C-8 Sterol Isomerase Activity Negative Regulation Of Cholesterol Transport Positive Regulation Of Macromolecule Biosynthetic Process Response To Laminar Fluid Shear Stress Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Establishment Of Protein Localization Titin-telethonin Complex Protein Kinase A Signaling Muscle Alpha-actinin Binding Mitotic Chromosome Condensation Detection Of Muscle Stretch Protein Kinase Regulator Activity Structural Molecule Activity Conferring Elasticity Actin-myosin Filament Sliding Striated Muscle Thin Filament Myosin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Actin Cytoskeleton Organization Actin Cytoskeleton Cardiac Myofibril Assembly Sarcomerogenesis Muscle Filament Sliding Actinin Binding Telethonin Binding Skeletal Muscle Thin Filament Assembly Sarcolemma Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
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