KLF13 and HMGN1

Data Source: HiPPIP (Novel)

		KLF13	HMGN1
Name		KLF transcription factor 13	high mobility group nucleosome binding domain 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Female Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Protein Binding Nucleosomal DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Pyrimidine Dimer Repair By Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Response To UV-B Response To UV-C Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Development, Heterochronic Post-embryonic Camera-type Eye Morphogenesis Regulation Of Epithelial Cell Proliferation
GWAS		Appendicular lean mass ( 33097823 ) Brain volume in infants (intracranial brain volume) ( 28763065 ) Deep white matter hyperintensities ( 32517579 ) Eosinophilic esophagitis ( 25017104 ) HDL cholesterol levels ( 32203549 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Mean corpuscular hemoglobin ( 29403010 32888494 ) Mean corpuscular volume ( 29403010 32888494 ) Psoriasis ( 28537254 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Triglyceride levels ( 32203549 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412 )	LDL cholesterol levels ( 32203549 ) Lipoprotein (a) levels ( 33730874 ) Smoking status (ever vs never smokers) ( 30643258 )
Novel Interactors		1 novel interactors: HMGN1	4 novel interactors: CAMSAP3 ETS2 KLF13 TMEM121B
Interacting Genes		9 interacting genes: CREBBP EP300 KAT2B PCBD1 PRP4K SERPINH1 SIN3A SREBF1 SREBF2	22 interacting genes: CDC42 CEBPA CHEK2 EP300 GSK3A HMGN2 HPF1 IRF2 LIG4 MDM2 NFE2 PARP1 PPP1CC PRKACA PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 YWHAZ
Entrez ID		51621	3150
HPRD ID		05620	01231
Ensembl ID		ENSG00000169926	ENSG00000205581
Uniprot IDs		Q9Y2Y9 X5DNR2	P05114 Q6NSG7
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		N-terminal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Chromatin Binding Acetyltransferase Activity Rhythmic Process Cellular Response To Nutrient Levels Histone Acetyltransferase Complex Histone H3K27 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity Chromatin Histone Acetyltransferase Activity Protein Acetylation Histone H3K18 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Response To Nutrient Levels Regulation Of Protein Localization L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Cellular Response To Stress Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation SREBP Signaling Pathway Cellular Response To Sterol Depletion Positive Regulation Of RNA Metabolic Process Nucleoplasm Internal Protein Amino Acid Acetylation Transcription Coactivator Activity Response To Sterol Depletion Protein Maturation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Heat Response To Stress Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Coregulator Activity Chromatin Organization Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Acyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process	TORC1 Signaling Regulation Of Nucleobase-containing Compound Metabolic Process TOR Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Macromolecule Metabolic Process Response To Nutrient Levels Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Steroid Hormone Protein Serine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Protein Domain Specific Binding Cellular Response To Stress Regulation Of DNA-templated Transcription Response To Gamma Radiation Regulation Of RNA Biosynthetic Process Cellular Response To Lithium Ion Regulation Of Gene Expression Protein Serine/threonine Kinase Activity Regulation Of Metabolic Process Response To Lithium Ion Chromatin Organization Histone H3S28 Kinase Activity Response To Hormone Regulation Of Transcription By RNA Polymerase II Protein Kinase Binding Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Radiation Chromosome, Telomeric Region Nucleus Negative Regulation Of Biosynthetic Process Protein Kinase Activity Protein Modification Process Protein Phosphorylation