KLF13 and PRP4K

Number of citations: 43 (PubMedID 17513757)
Data Source: HPRD (in vivo, two hybrid)

		KLF13	PRP4K
Name		KLF transcription factor 13	pre-mRNA processing factor kinase PRP4K
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Spliceosomal Complex Chromosome Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Hippo Signaling Positive Regulation Of Hippo Signaling MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Protein Export From Nucleus Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways		None	mRNA Splicing - Major Pathway
Drugs		None	Fostamatinib
GWAS		Appendicular lean mass ( 33097823 ) Brain volume in infants (intracranial brain volume) ( 28763065 ) Deep white matter hyperintensities ( 32517579 ) Eosinophilic esophagitis ( 25017104 ) HDL cholesterol levels ( 32203549 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Mean corpuscular hemoglobin ( 29403010 32888494 ) Mean corpuscular volume ( 29403010 32888494 ) Psoriasis ( 28537254 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Triglyceride levels ( 32203549 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412 )	No GWAS studies recorded
Interacting Genes		9 interacting genes: CREBBP EP300 KAT2B PCBD1 PRP4K SERPINH1 SIN3A SREBF1 SREBF2	9 interacting genes: CLK1 HSPB3 KLF13 PNN POLR3F RNF10 SRPK2 SRSF1 YWHAG
Entrez ID		51621	8899
HPRD ID		05620	09087
Ensembl ID		ENSG00000169926	ENSG00000112739
Uniprot IDs		Q9Y2Y9 X5DNR2	Q13523
PDB IDs		Not available	4IAN 4IFC 4IIR 4IJP 6CNH 6PJJ 6PK6 6QX9 8H6E 8H6J 8QXD 8R08 8R0A 8Y6O
GO Terms Enriched among Interactors		N-terminal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Chromatin Binding Acetyltransferase Activity Rhythmic Process Cellular Response To Nutrient Levels Histone Acetyltransferase Complex Histone H3K27 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity Chromatin Histone Acetyltransferase Activity Protein Acetylation Histone H3K18 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Response To Nutrient Levels Regulation Of Protein Localization L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Cellular Response To Stress Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation SREBP Signaling Pathway Cellular Response To Sterol Depletion Positive Regulation Of RNA Metabolic Process Nucleoplasm Internal Protein Amino Acid Acetylation Transcription Coactivator Activity Response To Sterol Depletion Protein Maturation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Heat Response To Stress Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Coregulator Activity Chromatin Organization Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Acyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process	Regulation Of RNA Splicing Nuclear Speck Exon-exon Junction Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Peptidyl-serine Phosphorylation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Protein Serine Kinase Activity Nucleus Macromolecule Metabolic Process RNA Metabolic Process RNA Splicing Catalytic Step 2 Spliceosome Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Protein Localization To P-body Positive Regulation Of Neuron Apoptotic Process Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process Protein Serine/threonine Kinase Activity MRNA Processing Protein Kinase C Inhibitor Activity Positive Regulation Of Interleukin-6-mediated Signaling Pathway Death Domain Binding Regulation Of MRNA Splicing, Via Spliceosome DNA Topoisomerase Binding Nuclear Speck Organization Regulation Of Macromolecule Metabolic Process Protein Kinase Activity Regulation Of MRNA Processing Positive Regulation Of MiRNA Processing Peptidyl-serine Autophosphorylation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane