KLF13 and SREBF1

Number of citations: 0 (PubMedID 16303770)
Data Source: BioGRID (pull down)

		KLF13	SREBF1
Name		KLF transcription factor 13	sterol regulatory element binding transcription factor 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Protein Kinase Binding Sterol Response Element Binding Sequence-specific DNA Binding Protein-containing Complex Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Heart Rate By Chemical Signal Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Lipid Metabolic Process Cholesterol Biosynthetic Process Response To Nutrient Circadian Rhythm Steroid Metabolic Process Cholesterol Metabolic Process Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Cellular Response To Starvation Response To Xenobiotic Stimulus Response To Glucose Response To Fructose Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Insulin Secretion Lung Development Intracellular Receptor Signaling Pathway Regulation Of Protein Stability Response To Food Response To Retinoic Acid Response To Progesterone Cellular Response To Insulin Stimulus SREBP Signaling Pathway Response To Glucagon Response To Lipid MRNA Transcription By RNA Polymerase II Response To Peptide Hormone Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Response To CAMP Response To Fatty Acid Cellular Response To Fatty Acid Negative Regulation Of Triglyceride Metabolic Process Regulation Of Mitophagy Positive Regulation Of MiRNA Transcription Regulation Of Protein Targeting To Mitochondrion
Pathways		None	Cholesterol biosynthesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs		None	Doconexent Omega-3-acid ethyl esters Omega-3 fatty acids Fish oil
GWAS		Appendicular lean mass ( 33097823 ) Brain volume in infants (intracranial brain volume) ( 28763065 ) Deep white matter hyperintensities ( 32517579 ) Eosinophilic esophagitis ( 25017104 ) HDL cholesterol levels ( 32203549 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Mean corpuscular hemoglobin ( 29403010 32888494 ) Mean corpuscular volume ( 29403010 32888494 ) Psoriasis ( 28537254 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Triglyceride levels ( 32203549 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412 )	Coffee consumption ( 31046077 ) Eosinophil count ( 32888494 ) Hip index ( 34021172 ) Lymphocyte count ( 32888494 ) Parkinson's disease ( 21738487 ) Resting heart rate ( 27798624 ) Schizophrenia ( 25056061 28991256 29483656 ) TB-LM or TBLH-BMD (pleiotropy) ( 28743860 ) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 )
Novel Interactors		1 novel interactors: HMGN1	1 novel interactors: MAPK7
Interacting Genes		9 interacting genes: CREBBP EP300 KAT2B PCBD1 PRP4K SERPINH1 SIN3A SREBF1 SREBF2	42 interacting genes: AR ATXN1 ATXN1L CDK8 CREBBP DDX39B EP300 ESR1 ESR2 GSK3B HNF4A ID2 ID3 KLF13 LMNA MAPK1 MAPK3 MECOM MED1 MED12 MED13 MED14 MED17 MED23 MED24 MED25 MED26 MED6 MED7 MTNR1B NR0B1 NR5A2 PLK1 PRMT5 SMARCC1 SMARCD3 SP1 SUMO1 TWIST2 UBE2I YY1 ZBTB7C
Entrez ID		51621	6720
HPRD ID		05620	01701
Ensembl ID		ENSG00000169926	ENSG00000072310
Uniprot IDs		Q9Y2Y9 X5DNR2	B3KR77 P36956
PDB IDs		Not available	1AM9
GO Terms Enriched among Interactors		N-terminal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Chromatin Binding Acetyltransferase Activity Rhythmic Process Cellular Response To Nutrient Levels Histone Acetyltransferase Complex Histone H3K27 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity Chromatin Histone Acetyltransferase Activity Protein Acetylation Histone H3K18 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Response To Nutrient Levels Regulation Of Protein Localization L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Cellular Response To Stress Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation SREBP Signaling Pathway Cellular Response To Sterol Depletion Positive Regulation Of RNA Metabolic Process Nucleoplasm Internal Protein Amino Acid Acetylation Transcription Coactivator Activity Response To Sterol Depletion Protein Maturation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Heat Response To Stress Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Coregulator Activity Chromatin Organization Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Acyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Mediator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Core Mediator Complex Positive Regulation Of Transcription Initiation By RNA Polymerase II Nucleus Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Initiation Transcription Coregulator Activity Transcription Preinitiation Complex Assembly Transcription Coactivator Activity Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Vitamin D Receptor Binding Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Assembly Transcription Coactivator Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Somatic Stem Cell Population Maintenance Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Rhythmic Process