DDX24 and PRF1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		DDX24	PRF1
Description		DEAD-box helicase 24	perforin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Membrane	Immunological Synapse Extracellular Region Lysosome Endosome Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Endosome Lumen Cytolytic Granule Cytolytic Granule Lumen
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Calcium Ion Binding Protein Binding Wide Pore Channel Activity Identical Protein Binding Metal Ion Binding Pore-forming Activity
	Biological Process	RNA Metabolic Process	Immunological Synapse Formation Plasma Membrane Repair Leukocyte Mediated Cytotoxicity T Cell Mediated Cytotoxicity Defense Response To Tumor Cell Immune Response To Tumor Cell Positive Regulation Of Immune Response To Tumor Cell Apoptotic Process Cellular Defense Response Protein Secretion Protein Import Killing Of Cells Of Another Organism Ceramide Biosynthetic Process Protein Homooligomerization Protein Maturation Defense Response To Virus Positive Regulation Of Killing Of Cells Of Another Organism Protein Transmembrane Transport Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death
Pathways			Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases			Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Post bronchodilator FEV1/FVC ratio ( 26634245)	Lymphocyte count ( 32888494) Multiple keratinocyte cancers ( 28081215) Obesity (extreme) ( 19553259) Type 1 diabetes ( 34012112)
Interacting Genes		37 interacting genes: BCS1L BRCA1 CSNK2A1 EIF3E EP300 FADD FILNC1 GIT1 GLRA2 HSP90AB1 HSPA5 IDO1 ITGB3BP LMNA MDM2 MKS1 MRPL4 NRXN2 PAFAH1B3 PIN1 POLA2 PRF1 PTEN PTPN23 RAE1 RNF10 SPACA9 SPTAN1 TERF1 TERF2 TERF2IP TMEM9B TPI1 TRDMT1 UBE2I USP7 VDAC3	12 interacting genes: CALR CYSRT1 DDX24 GZMB KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-8 NBPF19 NOTCH2NLA TRIM54
Entrez ID		57062	5551
HPRD ID		05860	01362
Ensembl ID		ENSG00000089737	ENSG00000180644
Uniprot IDs		Q9GZR7	P14222
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA-templated DNA Biosynthetic Process Shelterin Complex Cellular Component Assembly Nuclear Body Regulation Of Protein Stability Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Negative Regulation Of Cellular Component Organization Telomere Capping Regulation Of Cellular Component Organization PML Body Regulation Of Telomere Maintenance Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Organelle Organization Protein Localization To Organelle Negative Regulation Of Macromolecule Metabolic Process Protein Stabilization Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Catabolic Process Telomere Maintenance Via Telomerase P53 Binding Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Regulation Of Cell Communication Protein-containing Complex Regulation Of Signaling Regulation Of Organelle Organization Telomeric DNA Binding Negative Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Telomere Maintenance Via Telomere Lengthening DNA Biosynthetic Process Nucleoplasm Regulation Of Cell Cycle Telomere Maintenance Receptor Serine/threonine Kinase Binding Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Regulation Of DNA Metabolic Process Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Protection From Non-homologous End Joining At Telomere Negative Regulation Of Small Molecule Metabolic Process	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Cytolytic Granule Epidermis Development
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