DDX24 and GLRA2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DDX24	GLRA2
Description		DEAD-box helicase 24	glycine receptor alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Membrane	Plasma Membrane Membrane Chloride Channel Complex Cell Projection Synapse Postsynaptic Membrane Glycinergic Synapse GABA-ergic Synapse Postsynaptic Specialization Membrane
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Glycine Binding Extracellularly Glycine-gated Chloride Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Glycine-gated Chloride Ion Channel Activity Metal Ion Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	RNA Metabolic Process	Monoatomic Ion Transport Chloride Transport Neuropeptide Signaling Pathway Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Cellular Response To Amino Acid Stimulus Cellular Response To Zinc Ion Cellular Response To Ethanol Chloride Transmembrane Transport
Pathways			Neurotransmitter receptors and postsynaptic signal transmission Neurotransmitter receptors and postsynaptic signal transmission
Drugs			Glycine Lindane Picrotoxin Ethanol Memantine Taurine
Diseases
GWAS		Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		37 interacting genes: BCS1L BRCA1 CSNK2A1 EIF3E EP300 FADD FILNC1 GIT1 GLRA2 HSP90AB1 HSPA5 IDO1 ITGB3BP LMNA MDM2 MKS1 MRPL4 NRXN2 PAFAH1B3 PIN1 POLA2 PRF1 PTEN PTPN23 RAE1 RNF10 SPACA9 SPTAN1 TERF1 TERF2 TERF2IP TMEM9B TPI1 TRDMT1 UBE2I USP7 VDAC3	5 interacting genes: BAG6 DDX24 GDI2 PSD SEC23A
Entrez ID		57062	2742
HPRD ID		05860	02379
Ensembl ID		ENSG00000089737	ENSG00000101958
Uniprot IDs		Q9GZR7	P23416
PDB IDs			5BKF 5BKG 7KUY 7L31
Enriched GO Terms of Interacting Partners?		RNA-templated DNA Biosynthetic Process Shelterin Complex Cellular Component Assembly Nuclear Body Regulation Of Protein Stability Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Negative Regulation Of Cellular Component Organization Telomere Capping Regulation Of Cellular Component Organization PML Body Regulation Of Telomere Maintenance Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Organelle Organization Protein Localization To Organelle Negative Regulation Of Macromolecule Metabolic Process Protein Stabilization Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Catabolic Process Telomere Maintenance Via Telomerase P53 Binding Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Regulation Of Cell Communication Protein-containing Complex Regulation Of Signaling Regulation Of Organelle Organization Telomeric DNA Binding Negative Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Telomere Maintenance Via Telomere Lengthening DNA Biosynthetic Process Nucleoplasm Regulation Of Cell Cycle Telomere Maintenance Receptor Serine/threonine Kinase Binding Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Regulation Of DNA Metabolic Process Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Protection From Non-homologous End Joining At Telomere Negative Regulation Of Small Molecule Metabolic Process	Rab GDP-dissociation Inhibitor Activity Negative Regulation Of Protein Localization To Cilium Mitotic DNA Replication Initiation Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair Leading Strand Elongation Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Maintenance Of Unfolded Protein BAT3 Complex Alpha DNA Polymerase:primase Complex COPII-coated Vesicle Budding DNA Replication, Synthesis Of Primer
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