CXCL16 and TMEM237

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CXCL16	TMEM237
Description		C-X-C motif chemokine ligand 16	transmembrane protein 237
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane	Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Nuclear Speck Photoreceptor Connecting Cilium Ciliary Transition Zone Cell Projection Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Cytokine Activity Chemokine Activity	Protein Binding
	Biological Process	Receptor-mediated Endocytosis Chemotaxis Signal Transduction T Cell Chemotaxis Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Response To Cytokine Response To Type II Interferon Response To Tumor Necrosis Factor Lymphocyte Chemotaxis	Cell Projection Organization Regulation Of Wnt Signaling Pathway Cilium Assembly
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058)	Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)
Interacting Genes		66 interacting genes: ADAMTSL4 APP AQP2 AQP6 AQP9 ARL13B ATP6V0E1 BIK CARD10 CCDC70 CD53 CERS4 CLDN7 CREB3L1 CXCR6 CYSRT1 FAM209A FFAR2 FKBP7 FNDC9 GJA8 GORAB GPR42 GPX8 HHATL HOXA1 KASH5 KIR2DL3 KRT31 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP5-9 LHFPL5 LMNA MDFI MFF MTUS2 MUC1 NBPF19 NEMP1 NOTCH2NLA PEX12 SAR1A SLC10A6 SLC16A2 SLC18A1 SLC39A1 SNCA SPN SSMEM1 STX1A TGM1 TLCD4 TMEM139 TMEM14B TMEM237 TMEM239 TMEM35A TMX2 TSPAN12	123 interacting genes: ABHD16A ADAM33 ADIPOQ APOD APOL3 AQP1 ARLN ATP13A1 BET1 BLCAP BNIP2 BTN2A2 C1GALT1 C3orf52 CBLIF CCDC167 CD53 CDS1 CFHR5 CFTR CLDN4 CLN6 CNIH3 CTSA CXCL16 CXCL9 CYB5B EFNA5 EMC6 ERMP1 EXTL1 FBXO7 FKBP14 FXYD6 FZD7 GJB2 GKN2 GPR152 GPR25 GPR42 GRM2 GUCA2A GYPA IER3IP1 IFNGR1 IGFBP5 INSIG1 INSIG2 JAGN1 LAT LEPROTL1 LPAR3 LRP10 LTA MFF MFSD6 MS4A13 OPRD1 ORMDL3 OTOP2 OTOP3 PLPPR2 PNLIPRP1 POMGNT1 PRB1 PRNP RETREG3 RHD ROBO2 RPRM RUSF1 SEC22A SERP2 SERPINE1 SFXN5 SLC12A7 SLC16A4 SLC29A2 SLC2A5 SLC30A8 SLC35A4 SLC35B2 SLC35B4 SLC35E4 SLC35G1 SLC38A2 SLC38A7 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC52A1 SLC5A4 SLC61A1 SLC7A1 SLC7A3 ST6GAL2 STRIT1 STX8 TLCD4 TM4SF19 TM6SF2 TMEFF2 TMEM107 TMEM11 TMEM128 TMEM144 TMEM147 TMEM179B TMEM201 TMEM254 TMEM42 TMEM60 TMEM72 TMEM86B TRARG1 UNC93A UNC93B1 UPK1B VAMP3 VEGFA YIPF6 ZFPL1
Entrez ID		58191	65062
HPRD ID		16103	12448
Ensembl ID		ENSG00000161921	ENSG00000155755
Uniprot IDs		Q9H2A7	Q96Q45
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Membrane Water Channel Activity Identical Protein Binding Cellular Response To Copper Ion Water Transport	Membrane Transmembrane Transport Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Chemical Homeostasis Plasma Membrane Transmembrane Transporter Activity Monoatomic Ion Transport Organic Anion Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Metal Ion Transport Monoatomic Cation Transport Homeostatic Process Monoatomic Cation Transmembrane Transport SREBP-SCAP-Insig Complex L-ornithine Transmembrane Transport L-ornithine Transmembrane Transporter Activity SNAP Receptor Activity Craniofacial Suture Morphogenesis Monoatomic Cation Transmembrane Transporter Activity Amino Acid Transport Regulation Of Smooth Muscle Cell-matrix Adhesion Carbohydrate Transmembrane Transport SREBP-SCAP Complex Retention In Endoplasmic Reticulum Ornithine Transport L-arginine Import Across Plasma Membrane Insulin Metabolic Process Carbohydrate Transport Retinal Ganglion Cell Axon Guidance Intracellular Chemical Homeostasis Transepithelial Water Transport Negative Regulation Of SREBP Signaling Pathway L-lysine Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Cellular Response To CAMP Import Across Plasma Membrane L-lysine Transmembrane Transport Zinc Ion Transmembrane Transport
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