BPGM and NEK3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		BPGM	NEK3
Description		bisphosphoglycerate mutase	NIMA related kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleus Cytoplasm Axon Cell Projection
	Molecular Function	Catalytic Activity Bisphosphoglycerate Mutase Activity Phosphoglycerate Mutase Activity Protein Binding Hydrolase Activity Isomerase Activity Intramolecular Phosphotransferase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Carbohydrate Metabolic Process Glycolytic Process Nucleoside Phosphate Metabolic Process Respiratory Gaseous Exchange By Respiratory System Oxygen Transport Cellular Response To Stress Defense Response To Protozoan Erythrocyte Development Establishment Of Blood-brain Barrier Neuroinflammatory Response Carbohydrate Derivative Catabolic Process	Mitotic Cell Cycle Protein Phosphorylation Cell Division
Pathways		Glycolysis
Drugs			Fostamatinib
Diseases		Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Blood protein levels ( 30072576)
Interacting Genes		9 interacting genes: AKT1 ATF6 ATP4B CEL EGR2 EHD2 GAPDH GRB2 NEK3	6 interacting genes: BPGM CDCA8 NMNAT1 PRLR VAV1 VAV2
Entrez ID		669	4752
HPRD ID		01961	04954
Ensembl ID		ENSG00000172331	ENSG00000136098
Uniprot IDs		A0A024R782 P07738	P51956 Q6ZN64
PDB IDs		1T8P 2A9J 2F90 2H4X 2H4Z 2H52 2HHJ 3NFY 7N3R 7N3S 7THI 8X2S
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Receptor Signaling Pathway ER-nucleus Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Endoplasmic Reticulum Unfolded Protein Response Regulation Of Myelination Regulation Of TRNA Methylation Rhombomere 5 Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Formation Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Protein Localization To Endoplasmic Reticulum ERBB Signaling Pathway Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Regulation Of Response To Endoplasmic Reticulum Stress TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Regulation Of Autophagy Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Endodeoxyribonuclease Activity Insulin Receptor Signaling Pathway Identical Protein Binding P-type Potassium:proton Transporter Activity Potassium:proton Exchanging ATPase Complex Acetylesterase Activity Rhombomere 3 Development Positive Regulation Of Schwann Cell Differentiation Brain Segmentation Myelination Axon Ensheathment Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Peptidyl-cysteine S-nitrosylase Activity Grb2-EGFR Complex Plasma Membrane Organization Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TORC2 Complex Binding Glucose Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Sterol Ester Esterase Activity Regulation Of Schwann Cell Differentiation Peptidyl-cysteine S-nitrosylation GAIT Complex	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-epsilon Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Phosphotyrosine Residue Binding Fc Receptor Signaling Pathway Cellular Response To Xenobiotic Stimulus Platelet Activation Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Size Phosphoglycerate Mutase Activity Nicotinamide Nucleotide Metabolic Process Bisphosphoglycerate Mutase Activity Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Prolactin Receptor Activity Positive Regulation Of Signal Transduction Nicotinate-nucleotide Adenylyltransferase Activity Negative Regulation Of Apoptotic DNA Fragmentation Nicotinamide-nucleotide Adenylyltransferase Activity ATP Metabolic Process Prolactin Signaling Pathway Activation Of Janus Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein ADP-ribosyltransferase-substrate Adaptor Activity ATP Generation From Poly-ADP-D-ribose Nicotinamide Metabolic Process Chromosome Passenger Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Guanyl-nucleotide Exchange Factor Activity Purine Ribonucleotide Metabolic Process Intramolecular Phosphotransferase Activity Establishment Of Blood-brain Barrier Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Positive Regulation Of Immune System Process Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Mammary Gland Epithelium Development Prostate Gland Growth Response To Xenobiotic Stimulus Regulation Of Cellular Component Size Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Small GTPase-mediated Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphorylation-dependent Protein Binding Positive Regulation Of Mitotic Cytokinesis
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