BPGM and ATP4B

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		BPGM	ATP4B
Name		bisphosphoglycerate mutase	ATPase H+/K+ transporting subunit beta
Structure			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Plasma Membrane Potassium:proton Exchanging ATPase Complex Sodium:potassium-exchanging ATPase Complex Membrane Apical Plasma Membrane
	Molecular Function	Catalytic Activity Bisphosphoglycerate Mutase Activity Phosphoglycerate Mutase Activity Protein Binding Hydrolase Activity Isomerase Activity Intramolecular Phosphotransferase Activity	ATPase Activator Activity Protein Binding P-type Potassium:proton Transporter Activity Heterocyclic Compound Binding
	Biological Process	Carbohydrate Metabolic Process Glycolytic Process Nucleoside Phosphate Metabolic Process Respiratory Gaseous Exchange By Respiratory System Oxygen Transport Cellular Response To Stress Defense Response To Protozoan Erythrocyte Development Establishment Of Blood-brain Barrier Neuroinflammatory Response Carbohydrate Derivative Catabolic Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Cell Adhesion Intracellular Potassium Ion Homeostasis Response To Lipopolysaccharide Sodium Ion Export Across Plasma Membrane PH Reduction Potassium Ion Transmembrane Transport Proton Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Glycolysis	Ion transport by P-type ATPases
Drugs		None	Dexlansoprazole Vonoprazan
Diseases		Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency	None
GWAS		Blood protein levels ( 30072576 )	Height ( 31562340 )
Interacting Genes		9 interacting genes: AKT1 ATF6 ATP4B CEL EGR2 EHD2 GAPDH GRB2 NEK3	6 interacting genes: AGO3 BPGM CCNDBP1 GPR42 STX1A ZC4H2
Entrez ID		669	496
HPRD ID		01961	00669
Ensembl ID		ENSG00000172331	ENSG00000186009
Uniprot IDs		A0A024R782 P07738	P51164
PDB IDs		1T8P 2A9J 2F90 2H4X 2H4Z 2H52 2HHJ 3NFY 7N3R 7N3S 7THI 8X2S	Not available
GO Terms Enriched among Interactors		Insulin-like Growth Factor Receptor Signaling Pathway ER-nucleus Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Endoplasmic Reticulum Unfolded Protein Response Regulation Of Myelination Regulation Of TRNA Methylation Rhombomere 5 Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Formation Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Protein Localization To Endoplasmic Reticulum ERBB Signaling Pathway Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Regulation Of Response To Endoplasmic Reticulum Stress TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Regulation Of Autophagy Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Endodeoxyribonuclease Activity Insulin Receptor Signaling Pathway Identical Protein Binding P-type Potassium:proton Transporter Activity Potassium:proton Exchanging ATPase Complex Acetylesterase Activity Rhombomere 3 Development Positive Regulation Of Schwann Cell Differentiation Brain Segmentation Myelination Axon Ensheathment Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Peptidyl-cysteine S-nitrosylase Activity Grb2-EGFR Complex Plasma Membrane Organization Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TORC2 Complex Binding Glucose Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Sterol Ester Esterase Activity Regulation Of Schwann Cell Differentiation Peptidyl-cysteine S-nitrosylation GAIT Complex	None