PIP and SPI1

Number of citations of the paper that reports this interaction (PubMedID 11133986)
0

Data Source:
HPRD (in vivo, in vitro)

		PIP	SPI1
Description		prolactin induced protein	Spi-1 proto-oncogene
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Extracellular Exosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Actin Binding Aspartic-type Endopeptidase Activity Protein Binding IgG Binding Identical Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Repressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding NFAT Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding STAT Family Protein Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Regulation Of Immune System Process Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of T Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculature Development Germinal Center B Cell Differentiation Follicular B Cell Differentiation Lymphoid Progenitor Cell Differentiation Immature B Cell Differentiation Defense Response To Tumor Cell Pro-T Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Lymphocyte Differentiation Cell Differentiation Erythrocyte Differentiation Macrophage Differentiation Osteoclast Differentiation Granulocyte Differentiation Lipopolysaccharide-mediated Signaling Pathway Somatic Stem Cell Population Maintenance TRAIL-activated Apoptotic Signaling Pathway Myeloid Dendritic Cell Differentiation Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Neutrophil Degranulation Negative Regulation Of MHC Class II Biosynthetic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Regulation Of Erythrocyte Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Regression Interleukin-6-mediated Signaling Pathway Cellular Response To Ethanol Oncogene-induced Cell Senescence Endothelial To Hematopoietic Transition Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of P38MAPK Cascade Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of MiRNA Transcription Positive Regulation Of Microglial Cell Mediated Cytotoxicity Negative Regulation Of Adipose Tissue Development Pericyte Cell Differentiation Positive Regulation Of Antifungal Innate Immune Response Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Myeloid Dendritic Cell Chemotaxis
Pathways		Miscellaneous transport and binding events	RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
Drugs
Diseases			Acute myeloid leukemia (AML)
GWAS		Blood protein levels ( 30072576) Cancer ( 29299148) Dermatomyositis ( 27153935)	Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Blood urea nitrogen levels ( 31152163) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Experiencing mood swings ( 29500382) Familial squamous cell lung carcinoma ( 29924316) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Hematocrit ( 32888494) Hematology traits ( 30576415) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 25173106) Lacunar stroke ( 33773637) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mean platelet volume ( 32888494) Medication use (diuretics) ( 31015401) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: CD4 NEIL3 SPI1 USP7	47 interacting genes: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FBXW7 FOS FUS GATA1 GATA2 GATA3 GFI1 GSK3B HDAC1 HOXA10 IRF1 IRF2 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 RUNX1 SIN3A SKI SPIB SSRP1 TBP TMX1
Entrez ID		5304	6688
HPRD ID		07179	01305
Ensembl ID		ENSG00000159763	ENSG00000066336
Uniprot IDs		P12273	A0AAA9YHK5 P17947
PDB IDs		3ES6	8E3K 8E3R 8E4H 8E5Y 8EBH 8EE9 8EJ6 8EJ8 8EK3 8EK8 8EKJ 8EKU 8EKV 8EKZ 8EM9 8EMD 8ENG 8EO1 8EO4 8EQG 8EQK 8EQL 8T9U 8UFF 8UFK 8UFZ 8UHK 8V9N 8VDH 8VDI
Enriched GO Terms of Interacting Partners?		Regulation Of Myeloid Cell Differentiation Response To Ethanol Macrophage Differentiation Immunoglobulin Binding Response To Methamphetamine Hydrochloride MHC Class II Protein Binding Response To Stress Interleukin-16 Binding Positive Regulation Of Leukocyte Differentiation Lymphocyte Differentiation Interleukin-16 Receptor Activity Cellular Response To Ionomycin Myeloid Cell Differentiation Helper T Cell Enhancement Of Adaptive Immune Response Myeloid Leukocyte Differentiation Acetylcholine Receptor Inhibitor Activity Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Neutrophil Degranulation Positive Regulation Of Microglial Cell Mediated Cytotoxicity Pericyte Cell Differentiation Endothelial To Hematopoietic Transition Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of Antifungal Innate Immune Response Pro-T Cell Differentiation NFAT Protein Binding Oncogene-induced Cell Senescence Negative Regulation Of Neutrophil Degranulation Negative Regulation Of MHC Class II Biosynthetic Process Follicular B Cell Differentiation Negative Regulation Of Protein Localization To Chromatin Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Depurination MCM Complex Binding Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Response To Alcohol Delamination Negative Regulation Of Adipose Tissue Development Bubble DNA Binding Regulation Of Protein Localization To Chromatin TRAIL-activated Apoptotic Signaling Pathway Germinal Center B Cell Differentiation Epigenetic Regulation Of Gene Expression Monoubiquitinated Protein Deubiquitination Cellular Response To Ether Interleukin-15-mediated Signaling Pathway	Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Myeloid Cell Differentiation DNA-templated Transcription Transcription By RNA Polymerase II Cell Differentiation Sequence-specific DNA Binding Regulation Of Cell Development Regulation Of Hemopoiesis Regulation Of Cell Differentiation Cellular Developmental Process
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