PIP and NEIL3

Number of citations of the paper that reports this interaction (PubMedID 35031058)
59

Data Source:
BioGRID (unspecified method)

		PIP	NEIL3
Description		prolactin induced protein	nei like DNA glycosylase 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Extracellular Exosome	Nucleus Nucleoplasm Chromosome
	Molecular Function	Actin Binding Aspartic-type Endopeptidase Activity Protein Binding IgG Binding Identical Protein Binding	Bubble DNA Binding Nucleic Acid Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Lyase Activity DNA N-glycosylase Activity Metal Ion Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity MCM Complex Binding
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Regulation Of Immune System Process Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of T Cell Apoptotic Process	Single Strand Break Repair DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation DNA Damage Response Interstrand Cross-link Repair Depurination
Pathways		Miscellaneous transport and binding events	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Defective Base Excision Repair Associated with NEIL3 NEIL3-mediated resolution of ICLs NEIL3-mediated resolution of ICLs
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cancer ( 29299148) Dermatomyositis ( 27153935)	Heart rate variability traits ( 17903306) Idiopathic dilated cardiomyopathy ( 29495422) Mastocytosis (KIT D816V positive) ( 33421400) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: CD4 NEIL3 SPI1 USP7	54 interacting genes: ACACA BTN1A1 CCN1 CIRBP CKAP4 CPNE8 CSDE1 DHX30 DSC1 EEF1E1-BLOC1S5 EIF2AK2 ELAVL1 FAM120A FXR1 GFAP H2BC21 HBA1 HDLBP HNRNPA0 HNRNPA2B1 HNRNPDL HNRNPR IGF2BP3 KRT13 KRT17 LPL MAP1B MAP4 MBP MYO1C NEDD4L NEFL PIP PLEC PRKDC PRKRA PRRC2A PSPC1 QKI RBMX RECQL RTCA SF1 STAU1 STK36 STRAP STRBP TP53 TWIST1 VARS1 VIM YBX1 YBX3 ZG16B
Entrez ID		5304	55247
HPRD ID		07179	16407
Ensembl ID		ENSG00000159763	ENSG00000109674
Uniprot IDs		P12273	Q8TAT5
PDB IDs		3ES6	7JL5 7TMY
Enriched GO Terms of Interacting Partners?		Regulation Of Myeloid Cell Differentiation Response To Ethanol Macrophage Differentiation Immunoglobulin Binding Response To Methamphetamine Hydrochloride MHC Class II Protein Binding Response To Stress Interleukin-16 Binding Positive Regulation Of Leukocyte Differentiation Lymphocyte Differentiation Interleukin-16 Receptor Activity Cellular Response To Ionomycin Myeloid Cell Differentiation Helper T Cell Enhancement Of Adaptive Immune Response Myeloid Leukocyte Differentiation Acetylcholine Receptor Inhibitor Activity Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Neutrophil Degranulation Positive Regulation Of Microglial Cell Mediated Cytotoxicity Pericyte Cell Differentiation Endothelial To Hematopoietic Transition Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of Antifungal Innate Immune Response Pro-T Cell Differentiation NFAT Protein Binding Oncogene-induced Cell Senescence Negative Regulation Of Neutrophil Degranulation Negative Regulation Of MHC Class II Biosynthetic Process Follicular B Cell Differentiation Negative Regulation Of Protein Localization To Chromatin Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Depurination MCM Complex Binding Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Response To Alcohol Delamination Negative Regulation Of Adipose Tissue Development Bubble DNA Binding Regulation Of Protein Localization To Chromatin TRAIL-activated Apoptotic Signaling Pathway Germinal Center B Cell Differentiation Epigenetic Regulation Of Gene Expression Monoubiquitinated Protein Deubiquitination Cellular Response To Ether Interleukin-15-mediated Signaling Pathway	RNA Binding Nucleic Acid Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of MRNA Catabolic Process Negative Regulation Of RNA Catabolic Process MRNA Binding MRNA Stabilization RNA Stabilization Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Stability Cytoplasmic Stress Granule Regulation Of RNA Stability Positive Regulation Of Gene Expression Double-stranded RNA Binding Regulation Of MRNA Metabolic Process Regulation Of Translation MRNA 3'-UTR Binding Intermediate Filament Cytoskeleton Positive Regulation Of Translation Intermediate Filament Organization Negative Regulation Of Catabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process CRD-mediated MRNA Stabilization MiRNA Binding Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Intermediate Filament RNA Processing Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Protein-containing Complex Organization Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cellular Component Assembly Spliceosomal Complex Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Translation Positive Regulation Of Biosynthetic Process MiRNA Transport Positive Regulation Of Macromolecule Metabolic Process 3'-UTR-mediated MRNA Stabilization Protein Binding Cytoplasm Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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