PIP and CD4

Number of citations of the paper that reports this interaction (PMID 10820003)
1

Data Source:
HPRD (in vivo, in vitro)

		PIP	CD4
Gene Name		prolactin-induced protein	CD4 molecule
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Apical Plasma Membrane Extracellular Vesicular Exosome	Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	Glycoprotein Binding Actin Binding Aspartic-type Endopeptidase Activity Protein Binding IgG Binding Protein Dimerization Activity	Glycoprotein Binding Receptor Activity Transmembrane Signaling Receptor Activity Extracellular Matrix Structural Constituent Protein Binding Zinc Ion Binding Coreceptor Activity Enzyme Binding Protein Kinase Binding MHC Class II Protein Binding Protein Homodimerization Activity
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Retina Homeostasis Regulation Of Immune System Process Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of T Cell Apoptotic Process	Cytokine Production Induction By Virus Of Host Cell-cell Fusion Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Viral Process T Cell Differentiation Entry Into Host Cell T Cell Costimulation Maintenance Of Protein Location In Cell T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Protein Palmitoleylation Positive Regulation Of Protein Kinase Activity Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Regulation Of T Cell Activation
Pathways			Vpu mediated degradation of CD4 Downstream TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Costimulation by the CD28 family Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Early Phase of HIV Life Cycle HIV Life Cycle TCR signaling Alpha-defensins PD-1 signaling Defensins Phosphorylation of CD3 and TCR zeta chains Nef Mediated CD4 Down-regulation Binding and entry of HIV virion Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS			Response to Vitamin E supplementation ( 22437554)
Protein-Protein Interactions		2 interactors: CD4 SPI1	38 interactors: ABCB1 ADRB2 CCR5 CD2 CD28 CD38 CD44 CD5 CD53 CD82 CTSD CXCL12 CXCR4 DPP4 FCGR3A HLA-DPA1 HLA-DQA2 HLA-DQB1 IL16 IL2RA INPPL1 KCNAB2 LAT LCK LGALS1 MAPK14 MARCH4 PI4KA PIK3R1 PIP PTPRC SELL SIVA1 SPG21 TFRC TNFRSF10A UBL7 UNC119
Entrez ID		5304	920
HPRD ID		07179	01740
Ensembl ID		ENSG00000159763	ENSG00000010610
Uniprot IDs		P12273	B0AZV7 B4DT49 P01730
PDB IDs		3ES6	1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1OPN 1OPT 1OPW 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4JM2
Enriched GO Terms of Interacting Partners?		Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Lymphocyte Differentiation Leukocyte Differentiation Regulation Of Cellular Amino Acid Metabolic Process Lymphocyte Activation Hypermethylation Of CpG Island Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of MHC Class II Biosynthetic Process Apoptotic Process Involved In Patterning Of Blood Vessels Hemopoiesis Negative Regulation Of Histone H4 Acetylation Cell Activation Immune System Development Lymphoid Progenitor Cell Differentiation Modulation By Virus Of Host Process Positive Regulation Of Interleukin-2 Biosynthetic Process Granulocyte Differentiation Regulation Of Histone H4 Acetylation Anatomical Structure Regression Macrophage Differentiation Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Modulation By Virus Of Host Morphology Or Physiology Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Protein Acetylation Regulation Of Interleukin-2 Biosynthetic Process Apoptotic Process Involved In Morphogenesis Myeloid Dendritic Cell Differentiation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Calcium-mediated Signaling Myeloid Dendritic Cell Activation Apoptotic Process Involved In Development Positive Regulation Of Interleukin-2 Production Defense Response To Gram-negative Bacterium Regulation Of Erythrocyte Differentiation Regulation Of Immune System Process Dendritic Cell Differentiation Developmental Programmed Cell Death T Cell Selection Regulation Of Calcium-mediated Signaling Entry Into Host Cell Histone H3 Acetylation Regulation Of Histone Acetylation Patterning Of Blood Vessels Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cytokine Biosynthetic Process Somatic Stem Cell Maintenance	Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Regulation Of Immune System Process Regulation Of T Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Positive Regulation Of Cell-cell Adhesion T Cell Costimulation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Stimulus Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune Response Signaling Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Lymphocyte Activation Leukocyte Aggregation Cellular Response To Stimulus Apoptotic Process Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Programmed Cell Death Response To Stress Leukocyte Migration Leukocyte Activation Cell Death Death Cell Activation Defense Response Homeostatic Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Locomotion Cell Migration Cell Motility Single Organismal Cell-cell Adhesion Cellular Chemical Homeostasis
Tagcloud ?		aggregating amidolytic behaved benzamidine bothrops cearensis chromatographies deae esterolytic ethylenediamine moojeni msp nan nitroanilide pge1 phenylmethylsulfonyl pipecolyl pmsf proteinases sbti sephacel sephadex tame tcti tetracetic torresea tosyl trasylol washed	allergen asthmatics box caat cd18 chemotactic coactivator complexity concert consists dyad exons ga gabp gabpalpha harbor inducible introns lymphocytes mast motifs posttranslational pro processed remote share supplementing symmetry tata tightly
Tagcloud (Difference) ?		aggregating amidolytic behaved benzamidine bothrops cearensis chromatographies deae esterolytic ethylenediamine moojeni msp nan nitroanilide pge1 phenylmethylsulfonyl pipecolyl pmsf proteinases sbti sephacel sephadex tame tcti tetracetic torresea tosyl trasylol washed	allergen asthmatics box caat cd18 chemotactic coactivator complexity concert consists dyad exons ga gabp gabpalpha harbor inducible introns lymphocytes mast motifs posttranslational pro processed remote share supplementing symmetry tata tightly
Tagcloud (Intersection) ?