SNX2 and DUSP10

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SNX2	DUSP10
Gene Name		sorting nexin 2	dual specificity phosphatase 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Membrane Membrane Extrinsic Component Of Membrane Lamellipodium Retromer Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity
	Biological Process	Intracellular Protein Transport Endocytosis Vesicle Organization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Protein Oligomerization Lamellipodium Morphogenesis	Inactivation Of MAPK Activity Regulation Of Adaptive Immune Response Protein Dephosphorylation Response To Stress JNK Cascade Response To Lipopolysaccharide Peptidyl-tyrosine Dephosphorylation Negative Regulation Of JUN Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Negative Regulation Of JNK Cascade Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of Brown Fat Cell Differentiation
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS			Colorectal cancer ( 20972440)
Protein-Protein Interactions		20 interactors: ACVR1B ACVR2B C1orf122 CSNK2B DUSP10 EGFR FNBP1 INSR LAMC1 LEPR MET NFYC PAK6 PDGFRA PDGFRB SNX1 SNX4 SNX5 SNX6 ZNF202	12 interactors: CMTM6 FHL2 FN1 HTT MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 RPS11 SLX1B SNX2
Entrez ID		6643	11221
HPRD ID		09332	12320
Ensembl ID		ENSG00000205302	ENSG00000143507
Uniprot IDs		B4DEK4 B7Z408 O60749	B4DDQ0 Q9Y6W6
PDB IDs			1ZZW 2OUC 2OUD 3TG1
Enriched GO Terms of Interacting Partners?		Regulation Of Kinase Activity Protein Autophosphorylation Regulation Of Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Signal Transduction By Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Cell Migration Positive Regulation Of Locomotion Protein Phosphorylation Regulation Of Cell Motility Phosphorylation Regulation Of Signaling Retina Vasculature Development In Camera-type Eye Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Metanephric Glomerular Capillary Formation Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Tissue Development Positive Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Chemotaxis Positive Regulation Of DNA Metabolic Process Digestive System Development Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Glomerular Capillary Formation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Cellular Protein Metabolic Process Retrograde Transport, Endosome To Golgi Tube Morphogenesis Endosomal Transport Metanephric Glomerulus Vasculature Development Digestive Tract Morphogenesis	Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response MAPK Cascade Regulation Of Innate Immune Response Signal Transduction By Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of MAPK Activity Immune Response-regulating Signaling Pathway JUN Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Neurotrophin Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Immune Response Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Defense Response Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Cellular Response To Lipid Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of Immune System Process Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Cellular Response To Lipopolysaccharide Response To Radiation Response To Stress Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Protein Kinase Activity
Tagcloud ?		assembles assembling autonomously cation comprises conflicting endosomal endosomes heterodimer heterotrimer homodimer interchangeable mammalian mannose named nexin obligate performing retrieval retromer retromers snx1 sorting subcomplexes tgn truly vps26 vps29 vps35	bc bcs dephosphorylate differentially distant dmfs dusp4 dusp6 enpp1 erbb2 erk ihc inpp4b microarray microarrays motility multiphosphatase phosphatases phosphatome phospho ppapdc1a relevance seemed series sharing signature subgroups unlike warranted
Tagcloud (Difference) ?		assembles assembling autonomously cation comprises conflicting endosomal endosomes heterodimer heterotrimer homodimer interchangeable mammalian mannose named nexin obligate performing retrieval retromer retromers snx1 sorting subcomplexes tgn truly vps26 vps29 vps35	bc bcs dephosphorylate differentially distant dmfs dusp4 dusp6 enpp1 erbb2 erk ihc inpp4b microarray microarrays motility multiphosphatase phosphatases phosphatome phospho ppapdc1a relevance seemed series sharing signature subgroups unlike warranted
Tagcloud (Intersection) ?