SNX2 and SNX6

Number of citations of the paper that reports this interaction (PMID 11279102)
30

Data Source:
HPRD (in vitro, in vivo)

		SNX2	SNX6
Gene Name		sorting nexin 2	sorting nexin 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Membrane Membrane Extrinsic Component Of Membrane Lamellipodium Retromer Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome	Intracellular Nucleus Cytoplasm Cytoplasmic Membrane-bounded Vesicle Extrinsic Component Of Membrane Retromer Complex Early Endosome Membrane Tubular Endosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding	Protein Binding Dynactin Binding Phosphatidylinositol Binding Protein Homodimerization Activity
	Biological Process	Intracellular Protein Transport Endocytosis Vesicle Organization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Protein Oligomerization Lamellipodium Morphogenesis	Intracellular Protein Transport Endocytosis Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Vesicle Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Retrograde Transport, Endosome To Golgi Negative Regulation Of Transcription, DNA-templated Regulation Of Histamine Secretion By Mast Cell
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ACVR1B ACVR2B C1orf122 CSNK2B DUSP10 EGFR FNBP1 INSR LAMC1 LEPR MET NFYC PAK6 PDGFRA PDGFRB SNX1 SNX4 SNX5 SNX6 ZNF202	22 interactors: ACVR2B ACVRL1 BMPR1B BRCA1 BRMS1 CALM1 COIL CSNK2A2 DISC1 EGFR INSR LEPR NDEL1 PDGFRA PIM1 SNX1 SNX2 SNX4 TGFBR1 TGFBR2 TNIK TPT1
Entrez ID		6643	58533
HPRD ID		09332	12086
Ensembl ID		ENSG00000205302	ENSG00000129515
Uniprot IDs		B4DEK4 B7Z408 O60749	B4DJS7 Q9UNH7
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Kinase Activity Protein Autophosphorylation Regulation Of Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Signal Transduction By Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Cell Migration Positive Regulation Of Locomotion Protein Phosphorylation Regulation Of Cell Motility Phosphorylation Regulation Of Signaling Retina Vasculature Development In Camera-type Eye Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Metanephric Glomerular Capillary Formation Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Tissue Development Positive Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Chemotaxis Positive Regulation Of DNA Metabolic Process Digestive System Development Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Glomerular Capillary Formation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Cellular Protein Metabolic Process Retrograde Transport, Endosome To Golgi Tube Morphogenesis Endosomal Transport Metanephric Glomerulus Vasculature Development Digestive Tract Morphogenesis	Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction By Phosphorylation Regulation Of Signaling Developmental Process Positive Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Anatomical Structure Development Phosphorylation Intracellular Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Development Regulation Of Phosphorylation Activation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Differentiation Cellular Protein Modification Process Cellular Response To Growth Factor Stimulus Regulation Of Metabolic Process Sensory Organ Development Camera-type Eye Development Response To Growth Factor Positive Regulation Of Signal Transduction Retina Vasculature Development In Camera-type Eye Eye Development Phosphate-containing Compound Metabolic Process Protein Autophosphorylation Regulation Of Catalytic Activity Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Proliferation Palate Development Activin Receptor Signaling Pathway Chordate Embryonic Development Embryo Development
Tagcloud ?		assembles assembling autonomously cation comprises conflicting endosomal endosomes heterodimer heterotrimer homodimer interchangeable mammalian mannose named nexin obligate performing retrieval retromer retromers snx1 sorting subcomplexes tgn truly vps26 vps29 vps35
Tagcloud (Difference) ?		assembles assembling autonomously cation comprises conflicting endosomal endosomes heterodimer heterotrimer homodimer interchangeable mammalian mannose named nexin obligate performing retrieval retromer retromers snx1 sorting subcomplexes tgn truly vps26 vps29 vps35
Tagcloud (Intersection) ?