SNX2 and SNX4

Number of citations of the paper that reports this interaction (PubMedID 9819414)
41

Data Source:
HPRD (in vivo, in vitro)

		SNX2	SNX4
Description		sorting nexin 2	sorting nexin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Cell Projection	Cytoplasm Endosome Early Endosome Cytoplasmic Dynein Complex Plasma Membrane Membrane SNARE Complex Early Endosome Membrane Protein-containing Complex Presynaptic Endosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Intracellular Protein Transport Protein Transport Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Lamellipodium Morphogenesis	Protein Transport Endocytic Recycling Positive Regulation Of Histamine Secretion By Mast Cell Positive Regulation Of Autophagosome Assembly
Pathways		Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Plateletcrit ( 32888494) Subcortical volume (MOSTest) ( 32665545)	Adult body size ( 32376654) Estimated glomerular filtration rate in non-diabetics ( 31451708) Major depressive disorder x sex interaction ( 34099189) Urate levels ( 31578528)
Interacting Genes		27 interacting genes: ACVR1B ACVR2B ARL6IP1 C1orf122 CENPQ CSNK2B DUSP10 EGFR FNBP1 INSR LAMC1 LEPR MET MTIF3 NFYC PAK6 PDGFRA PDGFRB PLIN3 PNKP SNX1 SNX4 SNX6 TMEM239 VAPA YIF1A ZNF202	18 interacting genes: AGK ARL6IP1 ATP6V0A1 BIN1 DGAT2L6 EGFR HIVEP1 INSR LEPR MAGEA6 OGT PDGFRA PDGFRB PTPN5 SH3GLB1 SNX2 SNX6 SUPT5H
Entrez ID		6643	8723
HPRD ID		09332	09334
Ensembl ID		ENSG00000205302	ENSG00000114520
Uniprot IDs		O60749	O95219
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Activin Receptor Signaling Pathway Kinase Activity Protein Kinase Activity Retina Vasculature Development In Camera-type Eye Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Response To Growth Factor Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity Vascular Endothelial Growth Factor Binding Retromer, Tubulation Complex Leptin Receptor Binding Glomerular Capillary Formation Protein Autophosphorylation Enzyme-linked Receptor Protein Signaling Pathway Activin Receptor Complex Vesicle-mediated Transport Regulation Of Histamine Secretion By Mast Cell Regulation Of Cell Migration Vasculature Development Regulation Of Cell Motility Activin Binding Cadherin Binding Platelet-derived Growth Factor Binding Transferrin Receptor Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity ATP Binding Regulation Of Locomotion Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Cell Motility Positive Regulation Of Signaling Regulation Of Signaling Platelet-derived Growth Factor Receptor Binding Cardiac Myofibril Assembly Regulation Of Signal Transduction Anatomical Structure Morphogenesis Early Endosome Membrane Positive Regulation Of Locomotion Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Respiratory Burst Vascular Endothelial Growth Factor Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Autophagy Receptor Complex Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Vascular Endothelial Growth Factor Binding Retromer, Tubulation Complex Protein Tyrosine Kinase Activity Glomerular Capillary Formation Lipid Binding Regulation Of Macroautophagy Platelet-derived Growth Factor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet-derived Growth Factor Receptor Binding Retina Vasculature Development In Camera-type Eye Cardiac Myofibril Assembly Regulation Of Glucose Metabolic Process Cellular Response To Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Endosome Membrane Membrane Retromer Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Protein Autophosphorylation Response To Growth Factor Adrenal Gland Development Kinase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Myofibril Assembly Negative Regulation Of ERBB Signaling Pathway Cellular Localization Negative Regulation Of Catabolic Process Phosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Process Endosome Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Organelle Organization Protein-containing Complex Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Leptin Receptor Activity Platelet-derived Growth Factor Alpha-receptor Activity Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
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