SNX2 and FNBP1

Number of citations of the paper that reports this interaction (PubMedID 11438682)
36

Data Source:
HPRD (two hybrid, in vivo)

		SNX2	FNBP1
Description		sorting nexin 2	formin binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Cell Projection	Cytoplasm Lysosome Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Cell Cortex Membrane Cytoplasmic Vesicle
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Intracellular Protein Transport Protein Transport Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Lamellipodium Morphogenesis	Endocytosis Signal Transduction
Pathways		Golgi Associated Vesicle Biogenesis	Clathrin-mediated endocytosis CDC42 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RND2 GTPase cycle
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Plateletcrit ( 32888494) Subcortical volume (MOSTest) ( 32665545)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota relative abundance (unassigned genus belonging to family Clostridiales) ( 33208821) LDL peak particle diameter (total fat intake interaction) ( 26112879) Pediatric autoimmune diseases ( 26301688) Physiological dysregulation (Mahalanobis distance) ( 32235003)
Interacting Genes		27 interacting genes: ACVR1B ACVR2B ARL6IP1 C1orf122 CENPQ CSNK2B DUSP10 EGFR FNBP1 INSR LAMC1 LEPR MET MTIF3 NFYC PAK6 PDGFRA PDGFRB PLIN3 PNKP SNX1 SNX4 SNX6 TMEM239 VAPA YIF1A ZNF202	14 interacting genes: AGTR1 AKAP9 ARHGAP17 CBL CDC42 CEBPA DNM1 FASLG ITSN1 PDE6G RND2 SNX2 TNKS WASL
Entrez ID		6643	23048
HPRD ID		09332	10446
Ensembl ID		ENSG00000205302	ENSG00000187239
Uniprot IDs		O60749	A0A8V8TQ35 A0A994J3U5 A0A994J3V8 B7ZL13 B7ZL14 H0Y7W6 Q96RU3
PDB IDs			2EFL
Enriched GO Terms of Interacting Partners?		Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Activin Receptor Signaling Pathway Kinase Activity Protein Kinase Activity Retina Vasculature Development In Camera-type Eye Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Response To Growth Factor Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity Vascular Endothelial Growth Factor Binding Retromer, Tubulation Complex Leptin Receptor Binding Glomerular Capillary Formation Protein Autophosphorylation Enzyme-linked Receptor Protein Signaling Pathway Activin Receptor Complex Vesicle-mediated Transport Regulation Of Histamine Secretion By Mast Cell Regulation Of Cell Migration Vasculature Development Regulation Of Cell Motility Activin Binding Cadherin Binding Platelet-derived Growth Factor Binding Transferrin Receptor Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity ATP Binding Regulation Of Locomotion Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Cell Motility Positive Regulation Of Signaling Regulation Of Signaling Platelet-derived Growth Factor Receptor Binding Cardiac Myofibril Assembly Regulation Of Signal Transduction Anatomical Structure Morphogenesis Early Endosome Membrane Positive Regulation Of Locomotion Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Respiratory Burst Vascular Endothelial Growth Factor Signaling Pathway	Regulation Of Cellular Component Organization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cytoplasmic Vesicle Regulation Of Plasma Membrane Organization Regulation Of Endocytosis Dendritic Spine Morphogenesis Regulation Of Postsynapse Organization Positive Regulation Of Filopodium Assembly Signal Transduction Positive Regulation Of Transport Endocytosis Dendritic Spine Organization Vesicle Budding From Membrane Protein Kinase Binding Lamellipodium Plasma Membrane Macrophage Differentiation Neuron Projection Organization Regulation Of Filopodium Assembly Postsynapse Organization Angiotensin Type I Receptor Activity Regulation Of Vesicle-mediated Transport Regulation Of Cytoskeleton Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Clathrin Coat Assembly Involved In Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Glutamatergic Synapse Regulation Of Transport Small GTPase-mediated Signal Transduction Bradykinin Receptor Binding Membrane Organization Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Cellular Response To Type II Interferon Import Into Cell Establishment Of Organelle Localization Cell Projection Morphogenesis Actin Filament Organization GBD Domain Binding Storage Vacuole Response To Vitamin B2 C/EBP Complex Vesicle Scission Clathrin-coated Pit Clathrin-dependent Synaptic Vesicle Endocytosis Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric
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