SNX2 and C1orf122

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SNX2	C1orf122
Description		sorting nexin 2	chromosome 1 open reading frame 122
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Cell Projection
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Intracellular Protein Transport Protein Transport Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Lamellipodium Morphogenesis
Pathways		Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Plateletcrit ( 32888494) Subcortical volume (MOSTest) ( 32665545)	Eyebrow thickness ( 26926045)
Interacting Genes		27 interacting genes: ACVR1B ACVR2B ARL6IP1 C1orf122 CENPQ CSNK2B DUSP10 EGFR FNBP1 INSR LAMC1 LEPR MET MTIF3 NFYC PAK6 PDGFRA PDGFRB PLIN3 PNKP SNX1 SNX4 SNX6 TMEM239 VAPA YIF1A ZNF202	2 interacting genes: NLGN3 SNX2
Entrez ID		6643	127687
HPRD ID		09332	13508
Ensembl ID		ENSG00000205302	ENSG00000197982
Uniprot IDs		O60749	Q6ZSJ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Activin Receptor Signaling Pathway Kinase Activity Protein Kinase Activity Retina Vasculature Development In Camera-type Eye Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Response To Growth Factor Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity Vascular Endothelial Growth Factor Binding Retromer, Tubulation Complex Leptin Receptor Binding Glomerular Capillary Formation Protein Autophosphorylation Enzyme-linked Receptor Protein Signaling Pathway Activin Receptor Complex Vesicle-mediated Transport Regulation Of Histamine Secretion By Mast Cell Regulation Of Cell Migration Vasculature Development Regulation Of Cell Motility Activin Binding Cadherin Binding Platelet-derived Growth Factor Binding Transferrin Receptor Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity ATP Binding Regulation Of Locomotion Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Cell Motility Positive Regulation Of Signaling Regulation Of Signaling Platelet-derived Growth Factor Receptor Binding Cardiac Myofibril Assembly Regulation Of Signal Transduction Anatomical Structure Morphogenesis Early Endosome Membrane Positive Regulation Of Locomotion Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Respiratory Burst Vascular Endothelial Growth Factor Signaling Pathway	Retromer, Tubulation Complex Transferrin Receptor Binding Lamellipodium Morphogenesis Leptin Receptor Binding Neurexin Family Protein Binding Asymmetric, Glutamatergic, Excitatory Synapse Regulation Of Respiratory Gaseous Exchange By Nervous System Process Inhibitory Postsynaptic Potential Positive Regulation Of Glutamate Receptor Signaling Pathway Rhythmic Synaptic Transmission Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Regulation Of Glutamate Receptor Signaling Pathway Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Presynapse Assembly Presynaptic Membrane Organization Regulation Of Respiratory System Process Neuron Cell-cell Adhesion Early Endosome To Golgi Transport Presynapse Organization Retromer Complex Vocalization Behavior Insulin Receptor Binding Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Synapse Epidermal Growth Factor Receptor Binding Vesicle-mediated Transport Synaptic Vesicle Endocytosis Lamellipodium Organization Presynaptic Endocytosis Axon Extension Modulation Of Excitatory Postsynaptic Potential Social Behavior Membrane Assembly Positive Regulation Of Synapse Assembly Establishment Of Localization In Cell Endocytic Vesicle Scaffold Protein Binding Regulation Of Synaptic Transmission, Glutamatergic Neuron Projection Extension Vesicle-mediated Transport In Synapse Cell Adhesion Molecule Binding Retrograde Transport, Endosome To Golgi Synapse Assembly Regulation Of Postsynaptic Membrane Potential Phosphatidylinositol Binding
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