ARL6IP1 and STARD4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARL6IP1	STARD4
Description		ARL6 interacting reticulophagy regulator 1	StAR related lipid transfer domain containing 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane Endoplasmic Reticulum Tubular Network	Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Vesicle
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Lipid Binding Cholesterol Binding Cholesterol Transfer Activity
	Biological Process	Positive Regulation Of L-glutamate Import Across Plasma Membrane Cotranslational Protein Targeting To Membrane Apoptotic Process Negative Regulation Of Apoptotic Process Endoplasmic Reticulum Tubular Network Formation Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Membrane Organization	Lipid Transport Cholesterol Transport Involved In Cholesterol Storage Intracellular Cholesterol Transport Cholesterol Import Positive Regulation Of Bile Acid Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process
Pathways			Pregnenolone biosynthesis
Drugs
Diseases
GWAS		Caffeine consumption from coffee or tea ( 33287642) Refractive error ( 32231278)	Asthma ( 31959851) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Diisocyanate-induced asthma ( 25918132) Menarche (age at onset) ( 25231870) PR interval ( 32439900)
Interacting Genes		78 interacting genes: ACSF2 AQP6 ARL4D ARL6 BCL2L13 C19orf18 CERT1 DIABLO DRC4 EHD3 EMP1 F2RL1 FBXW7 FDFT1 FXR2 GAD2 GOLPH3 GOLPH3L GORASP2 GPR151 GPR152 HGS HMGCL HSD17B13 INPP5K LMNA MCEMP1 MGST3 MIEF2 MTERF3 MYG1 NAPB NDRG4 NTAQ1 NUDT3 PAM16 PBX3 PICK1 PTPN9 RAB33A REEP6 RETREG3 RNF5 SDCBP SENP2 SHISA5 SHMT2 SLC10A6 SLC13A1 SLC35H1 SLC61A1 SLC71A2 SNX1 SNX10 SNX11 SNX12 SNX15 SNX2 SNX3 SNX4 SNX8 SPG21 STARD4 SUCLA2 TARS2 TFAM TMED8 TMEM14B TMEM248 TMEM258 TUFM UBE2I VMA21 WDFY2 WIPI2 YIPF4 ZFYVE21 ZNF391	6 interacting genes: AGTRAP ARL6IP1 CCHCR1 GDAP1 MTIF3 SYP
Entrez ID		23204	134429
HPRD ID		09641	06133
Ensembl ID		ENSG00000170540	ENSG00000164211
Uniprot IDs		Q15041	B0AZS2 Q96DR4
PDB IDs			6L1D 6L1M
Enriched GO Terms of Interacting Partners?		Lipid Binding Phosphatidylinositol Binding Cellular Localization Establishment Of Protein Localization Retromer Complex Intracellular Transport Protein Transport Membrane Establishment Of Localization In Cell Leptin Receptor Binding Localization Within Membrane Intracellular Protein Transport Early Endosome To Golgi Transport Intracellular Protein Localization Vesicle-mediated Transport To The Plasma Membrane Golgi Vesicle Transport Retrograde Transport, Endosome To Golgi Endosome Phosphatidylinositol-4-phosphate Binding Transferrin Receptor Binding Negative Regulation Of Early Endosome To Late Endosome Transport Endosomal Transport Endocytic Recycling Cytosolic Transport Early Endosome Membrane Phosphatidylinositol-3-phosphate Binding Protein Targeting To Golgi Apparatus Protein Binding Mitochondrial Matrix Early Endosome Retromer, Tubulation Complex Golgi Vesicle Budding Cargo Adaptor Activity Establishment Of Protein Localization To Plasma Membrane Insulin Receptor Binding Vesicle-mediated Transport Organelle Organization Phosphatidylinositol Phosphate Binding Late Endosome To Golgi Transport Succinate Metabolic Process Lamellipodium Morphogenesis Epidermal Growth Factor Receptor Binding Vesicle Budding From Membrane Protein Localization To Membrane Vesicle Organization Positive Regulation Of Exocytosis Regulation Of Establishment Of Protein Localization Membrane Organization Golgi Cisterna Regulation Of Protein Localization	Regulation Of Opioid Receptor Signaling Pathway Identical Protein Binding Sec61 Translocon Complex Protein Targeting Positive Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Angiotensin Type II Receptor Activity Mitochondrial Translational Initiation Organelle Organization Synaptic Vesicle Maturation Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Membrane Organization Neuron Projection Terminus Regulation Of Synaptic Vesicle Priming Endoplasmic Reticulum Tubular Network Membrane Organization Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Membrane Organization Regulation Of L-glutamate Import Across Plasma Membrane Endoplasmic Reticulum Tubular Network Organization Cotranslational Protein Targeting To Membrane Establishment Of Protein Localization Mitochondrial Fusion Cellular Response To Vitamin D Mitochondrial Fission Angiotensin-activated Signaling Pathway Translation Factor Activity, RNA Binding Ribosomal Small Subunit Binding Positive Regulation Of Amino Acid Transport
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