ARL6IP1 and SENP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ARL6IP1	SENP2
Description		ARL6 interacting reticulophagy regulator 1	SUMO specific peptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane Endoplasmic Reticulum Tubular Network	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Body PML Body Nuclear Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO-specific Endopeptidase Activity
	Biological Process	Positive Regulation Of L-glutamate Import Across Plasma Membrane Cotranslational Protein Targeting To Membrane Apoptotic Process Negative Regulation Of Apoptotic Process Endoplasmic Reticulum Tubular Network Formation Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Membrane Organization	Proteolysis Heart Development Protein Transport Wnt Signaling Pathway Protein Sumoylation Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of DNA Endoreduplication Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Regulation Of Macromolecule Metabolic Process Trophoblast Giant Cell Differentiation Labyrinthine Layer Development Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			SUMO is proteolytically processed
Drugs
Diseases
GWAS		Caffeine consumption from coffee or tea ( 33287642) Refractive error ( 32231278)	Diastolic blood pressure ( 27841878 28135244) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462 31152163) Height ( 28552196) Hip circumference ( 28552196) JT interval ( 29874175) PR interval ( 30046033 32439900) QRS duration ( 30012220) Seborrheic dermatitis ( 29203360) Systolic blood pressure ( 26969751 27841878)
Interacting Genes		78 interacting genes: ACSF2 AQP6 ARL4D ARL6 BCL2L13 C19orf18 CERT1 DIABLO DRC4 EHD3 EMP1 F2RL1 FBXW7 FDFT1 FXR2 GAD2 GOLPH3 GOLPH3L GORASP2 GPR151 GPR152 HGS HMGCL HSD17B13 INPP5K LMNA MCEMP1 MGST3 MIEF2 MTERF3 MYG1 NAPB NDRG4 NTAQ1 NUDT3 PAM16 PBX3 PICK1 PTPN9 RAB33A REEP6 RETREG3 RNF5 SDCBP SENP2 SHISA5 SHMT2 SLC10A6 SLC13A1 SLC35H1 SLC61A1 SLC71A2 SNX1 SNX10 SNX11 SNX12 SNX15 SNX2 SNX3 SNX4 SNX8 SPG21 STARD4 SUCLA2 TARS2 TFAM TMED8 TMEM14B TMEM248 TMEM258 TUFM UBE2I VMA21 WDFY2 WIPI2 YIPF4 ZFYVE21 ZNF391	40 interacting genes: ACSF2 AGTRAP APOC2 APOC4 APP AR ARL6IP1 ARMC12 AXIN1 CDCA5 CDK5RAP2 DAXX ERCC6 FUNDC1 FZR1 HCCS IKBKG KASH5 KPNA1 KPNB1 LMNA MYC NACC1 NEDD4L NUP153 OGT PML RANGAP1 RETREG3 RPRM SDR16C5 STK38 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TNFRSF10D TPD52 TRIM63
Entrez ID		23204	59343
HPRD ID		09641	07002
Ensembl ID		ENSG00000170540	ENSG00000163904
Uniprot IDs		Q15041	Q9HC62
PDB IDs			1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3 3ZO5 5AEK
Enriched GO Terms of Interacting Partners?		Lipid Binding Phosphatidylinositol Binding Cellular Localization Establishment Of Protein Localization Retromer Complex Intracellular Transport Protein Transport Membrane Establishment Of Localization In Cell Leptin Receptor Binding Localization Within Membrane Intracellular Protein Transport Early Endosome To Golgi Transport Intracellular Protein Localization Vesicle-mediated Transport To The Plasma Membrane Golgi Vesicle Transport Retrograde Transport, Endosome To Golgi Endosome Phosphatidylinositol-4-phosphate Binding Transferrin Receptor Binding Negative Regulation Of Early Endosome To Late Endosome Transport Endosomal Transport Endocytic Recycling Cytosolic Transport Early Endosome Membrane Phosphatidylinositol-3-phosphate Binding Protein Targeting To Golgi Apparatus Protein Binding Mitochondrial Matrix Early Endosome Retromer, Tubulation Complex Golgi Vesicle Budding Cargo Adaptor Activity Establishment Of Protein Localization To Plasma Membrane Insulin Receptor Binding Vesicle-mediated Transport Organelle Organization Phosphatidylinositol Phosphate Binding Late Endosome To Golgi Transport Succinate Metabolic Process Lamellipodium Morphogenesis Epidermal Growth Factor Receptor Binding Vesicle Budding From Membrane Protein Localization To Membrane Vesicle Organization Positive Regulation Of Exocytosis Regulation Of Establishment Of Protein Localization Membrane Organization Golgi Cisterna Regulation Of Protein Localization	Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Sumoylation Positive Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore Regulation Of Proteolysis Nuclear Membrane Protein Modification By Small Protein Conjugation Protein Localization To Nucleus PML Body Protein Tag Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein Import Into Nucleus Nuclear Envelope Import Into Nucleus Very-low-density Lipoprotein Particle Chromatin Organization Post-translational Protein Modification Endoplasmic Reticulum Tubular Network Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Nuclear Localization Sequence Binding High-density Lipoprotein Particle Regulation Of Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intermediate-density Lipoprotein Particle Nucleus Organization Protein Binding DNA Damage Response Positive Regulation Of Protein Metabolic Process Protein Localization To Organelle Regulation Of Proteasomal Protein Catabolic Process PML Body Organization Chromatin Remodeling Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Regulation Of Protein Localization Molecular Condensate Scaffold Activity Programmed Cell Death Protein Modification Process NLS-dependent Protein Nuclear Import Complex Meiotic Nuclear Membrane Microtubule Tethering Complex
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