ARL6IP1 and EHD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARL6IP1	EHD3
Description		ARL6 interacting reticulophagy regulator 1	EH domain containing 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane Endoplasmic Reticulum Tubular Network	Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Focal Adhesion Cilium Endosome Membrane Membrane Ciliary Pocket Membrane Endocytic Vesicle Cell Projection Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Ciliary Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Nucleotide Binding Nucleic Acid Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Positive Regulation Of L-glutamate Import Across Plasma Membrane Cotranslational Protein Targeting To Membrane Apoptotic Process Negative Regulation Of Apoptotic Process Endoplasmic Reticulum Tubular Network Formation Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Membrane Organization	Receptor Recycling Endocytosis Protein Transport Cell Projection Organization Endocytic Recycling Early Endosome To Golgi Transport Protein Homooligomerization Regulation Of Cardiac Muscle Contraction Cilium Assembly Protein Localization To Plasma Membrane Regulation Of Cardiac Muscle Cell Membrane Potential Golgi To Lysosome Transport Regulation Of Golgi Organization Regulation Of Cardiac Conduction
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Caffeine consumption from coffee or tea ( 33287642) Refractive error ( 32231278)	Estradiol levels ( 22675492) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Mean platelet volume ( 22139419 32888494 27863252 24026423 19820697) Metabolite levels ( 23823483) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494 22139419) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) White blood cell count ( 32888494)
Interacting Genes		78 interacting genes: ACSF2 AQP6 ARL4D ARL6 BCL2L13 C19orf18 CERT1 DIABLO DRC4 EHD3 EMP1 F2RL1 FBXW7 FDFT1 FXR2 GAD2 GOLPH3 GOLPH3L GORASP2 GPR151 GPR152 HGS HMGCL HSD17B13 INPP5K LMNA MCEMP1 MGST3 MIEF2 MTERF3 MYG1 NAPB NDRG4 NTAQ1 NUDT3 PAM16 PBX3 PICK1 PTPN9 RAB33A REEP6 RETREG3 RNF5 SDCBP SENP2 SHISA5 SHMT2 SLC10A6 SLC13A1 SLC35H1 SLC61A1 SLC71A2 SNX1 SNX10 SNX11 SNX12 SNX15 SNX2 SNX3 SNX4 SNX8 SPG21 STARD4 SUCLA2 TARS2 TFAM TMED8 TMEM14B TMEM248 TMEM258 TUFM UBE2I VMA21 WDFY2 WIPI2 YIPF4 ZFYVE21 ZNF391	4 interacting genes: ARL6IP1 EHD1 SNAP29 SNCA
Entrez ID		23204	30845
HPRD ID		09641	16170
Ensembl ID		ENSG00000170540	ENSG00000013016
Uniprot IDs		Q15041	Q9NZN3
PDB IDs
Enriched GO Terms of Interacting Partners?		Lipid Binding Phosphatidylinositol Binding Cellular Localization Establishment Of Protein Localization Retromer Complex Intracellular Transport Protein Transport Membrane Establishment Of Localization In Cell Leptin Receptor Binding Localization Within Membrane Intracellular Protein Transport Early Endosome To Golgi Transport Intracellular Protein Localization Vesicle-mediated Transport To The Plasma Membrane Golgi Vesicle Transport Retrograde Transport, Endosome To Golgi Endosome Phosphatidylinositol-4-phosphate Binding Transferrin Receptor Binding Negative Regulation Of Early Endosome To Late Endosome Transport Endosomal Transport Endocytic Recycling Cytosolic Transport Early Endosome Membrane Phosphatidylinositol-3-phosphate Binding Protein Targeting To Golgi Apparatus Protein Binding Mitochondrial Matrix Early Endosome Retromer, Tubulation Complex Golgi Vesicle Budding Cargo Adaptor Activity Establishment Of Protein Localization To Plasma Membrane Insulin Receptor Binding Vesicle-mediated Transport Organelle Organization Phosphatidylinositol Phosphate Binding Late Endosome To Golgi Transport Succinate Metabolic Process Lamellipodium Morphogenesis Epidermal Growth Factor Receptor Binding Vesicle Budding From Membrane Protein Localization To Membrane Vesicle Organization Positive Regulation Of Exocytosis Regulation Of Establishment Of Protein Localization Membrane Organization Golgi Cisterna Regulation Of Protein Localization	Ciliary Pocket Membrane Synaptic Vesicle Priming Ciliary Membrane Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Amine Transport Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Membrane Organization Organelle Organization Cellular Component Assembly Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Transport Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Exocytosis Regulation Of Serotonin Uptake Positive Regulation Of L-glutamate Import Across Plasma Membrane Mitochondrial ATP Synthesis Coupled Electron Transport Presynapse Cuprous Ion Binding Protein Complex Oligomerization Protein-containing Complex Organization Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Dopamine Uptake Involved In Synaptic Transmission Response To Growth Factor Negative Regulation Of Catecholamine Metabolic Process Cellular Response To Growth Factor Stimulus Response To Iron(II) Ion Dopamine Biosynthetic Process Protein-containing Complex Assembly Regulation Of Dopamine Uptake Involved In Synaptic Transmission Vesicle-mediated Transport Negative Regulation Of Cellular Respiration Cell Projection Negative Regulation Of Oxidative Phosphorylation Cilium Assembly Cilium Organization Establishment Of Protein Localization Autophagosome Membrane Docking Positive Regulation Of Endocytic Recycling Positive Regulation Of Cholesterol Storage Platelet Dense Tubular Network Membrane Sec61 Translocon Complex
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